林文孩
时间:2019-12-26

林文孩,博士,副研究员。2013年在吉林大学获学士学位,2019年在中国科学院大学长春应用化学研究所获博士学位(导师:谢志刚研究员),2019-2021年美国麻省大学医学院博士后(合作导师:Gang Han教授),2021-2022年中国香港香港城市大学博士后(合作导师:Stella W. Pang教授),2022年受聘为苏州大学副研究员。在国际主流期刊发表论文30余篇,被引用900余次。主要研究方向为多功能光敏剂和聚合物纳米粒用于肿瘤的诊断治疗。

论文

1.      Quan, L.; Moreno-Gonzalez, I.; Xie, Z.; Gamez, N.; Vegas-Gomez, L.; Song, Q.; Gu, J.Lin, W.; Gomez-Gutierrez, R.; Wu, T. A near-infrared probe for detecting and interposing amyloid beta oligomerization in early Alzheimer's disease. Alzheimer's & Dementia2022, 1-11.

2.      Zeng, L.; Huang, L.; Wang, Z.; Wei, J.; Huang, K.; Lin, W.; Duan, C.; Han, G. Self-Assembled Metal–Organic Framework Stabilized Organic Cocrystals for Biological Phototherapy. Angewandte Chemie International Edition2021, 60, 23569-23573.

3.       Li, C.; Lin, W.; Liu, S.; Sun, T.; Xie, Z. Structural optimization of organic fluorophores for highly efficient photothermal therapy. Materials Chemistry Frontiers2021, 5, 284-292.

4.       Lin, W.; Colombani-Garay, D.; Huang, L.; Duan, C.; Han, G. Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy. WIREs Nanomedicine and Nanobiotechnology2020, e1627.

5.       Huang, L.; Wu, W.; Li, Y.; Huang, K.; Zeng, L.; Lin, W.; Han, G. Highly Effective Near-Infrared Activating Triplet–Triplet Annihilation Upconversion for Photoredox Catalysis. Journal of the American Chemical Society 2020, 142, 18460-18470.

6.       Zhou, Y.; Zhang, Y.; Lin, W.; Kesseli, S. J.; Huang, L.; Zhao, Y.; Yao, X.; Huang, K.; Han, G. WavelengthSelective LightControlled Stepwise Photolysis from Single Gold Nanoparticles. Advanced Healthcare Materials2020, 2000321.

7.       Lin, W.; Zhang, W.; Liu, S.; Li, Z.; Hu, X.; Xie, Z.; Duan, C.; Han, G. Engineering pH-Responsive BODIPY Nanoparticles for Tumor Selective Multimodal Imaging and Phototherapy. ACS Applied Materials & Interfaces2019, 11, 43928-43935.

8.      Wang, X.; Lin, W.*; Zhang, W.; Li, C.; Sun, T.; Chen, G.; Xie, Z. Amphiphilic redox-sensitive NIR BODIPY nanoparticles for dual-mode imaging and photothermal therapy. Journal of Colloid and Interface Science 2019, 536, 208-214.

9.      Zhang, W.; Lin, W.; Li, C.; Liu, S.; Hu, X.; Xie, Z. Rational Design of BODIPY-Diketopyrrolopyrrole Conjugated Polymers for Photothermal Tumor Ablation. ACS Applied Materials & Interfaces2019, 11, 32720-32728.

10.    Li, C.; Lin, W.; Liu, S.; Zhang, W.; Xie, Z. Self-destructive PEG-BODIPY nanomaterials for photodynamic and photothermal therapy. Journal of Materials Chemistry B 2019, 7, 4655-4660.

11.    Quan, L.; Gu, J.; Lin, W.; Wei, Y.; Lin, Y.; Liu, L.; Ding, H.; Pan, C.; Xie, Z.; Wu, T. A BODIPY biosensor to detect and drive self-assembly of diphenylalanine. Chemical Communications 2019, 55, 8564-8566.

12.    Wang, X.; Fu, L.; Lin, W.; Zhang, W.; Pei, Q.; Zheng, X.; Liu, S.; Zhang, T.; Xie, Z. Vaginal delivery of mucus-penetrating organic nanoparticles for photothermal therapy against cervical intraepithelial neoplasia in mice. Journal of Materials Chemistry B 2019, 7, 4528-4537.

13.    Lin, W.; Yin, L.; Sun, T.; Wang, T.; Xie, Z.; Gu, J.; Jing, X. The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines. Biomacromolecules 2018, 19, 1625-1634.

14.    Zhu, Y.; Lin, W.*; Wang, X.; Zhang, W.; Chen, L.; Xie, Z. Constructing reduction-sensitive PEGylated NIRF mesoporous silica nanoparticles via a one-pot Passerini reaction for photothermal/chemo-therapy. Chemical Communications2018, 54, 11921-11924.

15.    Zhang, W.; Lin, W.; Wang, X.; Li, C.; Liu, S.; Xie, Z. Hybrid Nanomaterials of Conjugated Polymers and Albumin for Precise Photothermal Therapy. ACS Applied Materials & Interfaces 2018, 11, 278-287.

16.    Zong, S.; Wang, X.; Lin, W.; Liu, S.; Zhang, W. Simple D-A-D Structural Bisbithiophenyl Diketopyrrolopyrrole (TDPP) as Efficient Bioimaging and Photothermal Agents. Bioconjugate Chemistry2018, 29, 2619-2627.

17.    Lin, W.; Zhang, W.; Sun, T.; Liu, S.; Zhu, Y.; Xie, Z. Rational Design of Polymeric Nanoparticles with Tailorable Biomedical Functions for Cancer Therapy. ACS Applied Materials & Interfaces 2017, 9, 29612-29622.

18.    Zhu, Y.; Lin, W.*; Zhang, W.; Feng, Y.; Wu, Z.; Chen, L.; Xie, Z. PEGylated BODIPY Assembling Fluorescent Nanoparticles for Photodynamic Therapy. Chinese Chemical Letters 2017, 28, 1875-1877.

19.    Lin, W.; Xie, Z.; Jing, X. Self-Assembling Organic Nanoparticles for Bioimaging and Cargo Delivery. Journal of Controlled Release 2017, 259, e140-e141.

20.    Zhang, W.; Lin, W.; Zheng, X.; He, S.; Xie, Z. Comparing Effects of Redox Sensitivity of Organic Nanoparticles to Photodynamic Activity. Chemistry of Materials 2017, 29, 1856-1863.

21.    Lin, W.; Zhang, W.; Sun, T.; Gu, J.; Xie, Z.; Jing, X. Effect of Molecular Structure on Stability of Organic Nanoparticles Formed by Bodipy Dimers. Langmuir 2016, 32, 9575-9581.

22.    Lin, W.; Li, Y.; Zhang, W.; Liu, S.; Xie, Z.; Jing, X. Near-Infrared Polymeric Nanoparticles with High Content of Cyanine for Bimodal Imaging and Photothermal Therapy. ACS Applied Materials & Interfaces 2016, 8, 24426-24432.

23.    Lin, W.; Sun, T.; Xie, Z.; Gu, J.; Jing, X. A Dual-Responsive Nanocapsule via Disulfide-Induced Self-Assembly for Therapeutic Agent Delivery. Chemical Science 2016, 7, 1846-1852.

24.    Sun, T.; Lin, W; Zhang, W.; Xie, Z. SelfAssembly of Amphiphilic Drug–Dye Conjugates into Nanoparticles for Imaging and Chemotherapy. Chemistry – An Asian Journal2016, 11, 3174-3177.

25.    Zhang, W.; Lin, W.; Pei, Q.; Hu, X.; Xie, Z.; Jing, X. Redox-Hypersensitive Organic Nanoparticles for Selective Treatment of Cancer Cells. Chemistry of Materials 2016, 28, 4440-4446.

26.    Lin, W.; Guan, X.; Sun, T.; Huang, Y.; Jing, X.; Xie, Z. Reduction-Sensitive Amphiphilic Copolymers Made via Multi-Component Passerini Reaction for Drug Delivery. Colloids and Surfaces B: Biointerfaces 2015, 126, 217-223.

27.    Lin, W.; Sun, T.; Zheng, M.; Xie, Z.; Huang, Y.; Jing, X. Synthesis of Cross-Linked Polymers via Multi-Component Passerini Reaction and Their Application as Efficient Photocatalysts. RSC Advances 2014, 4, 25114.

28.    Zong, S.; Wang, X.; Yang, Y.; Wu, W.; Li, H.; Ma, Y.; Lin, W.; Sun, T.; Huang, Y.; Xie, Z.; Yue, Y.; Liu, S.; Jing, X. The Use of Cisplatin-Loaded Mucoadhesive Nanofibers for Local Chemotherapy of Cervical Cancers in Mice. European Journal of Pharmaceutics and Biopharmaceutics 2015, 93, 127-135.

29.    Quan, L.; Liu, S.; Sun, T.; Guan, X.; Lin, W.; Xie, Z.; Huang, Y.; Wang, Y.; Jing, X. Near-Infrared Emitting Fluorescent BODIPY Nanovesicles for in Vivo Molecular Imaging and Drug Delivery. ACS Applied Materials & Interfaces 2014, 6, 16166-16173.

30.    Quan, L.; Sun, T.; Lin, W.; Guan, X.; Zheng, M.; Xie, Z.; Jing, X. BODIPY Fluorescent Chemosensor for Cu2+ Detection and Its Applications in Living Cells: Fast Response and High Sensitivity. Journal of Fluorescence 2014, 24, 841-846.

31.    Quan, L.; Lin, W.; Sun, T.; Xie, Z.; Huang, Y.; Jing, X. Green Photocatalysis with Oxygen Sensitive BODIPYs under Visible Light. Catalysis Letters 2014, 144, 308-313.

32.    Hu, X.; Li, J.; Lin, W.; Huang, Y.; Jing, X.; Xie, Z. Paclitaxel Prodrug Nanoparticles Combining Chemical Conjugation and Physical Entrapment for Enhanced Antitumor Efficacy. RSC Advances 2014, 4, 38405-38411.