2021
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  • 2021

    207Z.Q. Zhang, Q. Zhang, J.G. Xie, Z.Y. Zhong*, C. Deng*, Enzyme-responsive micellar JQ1 induces enhanced BET proteins inhibition and immunotherapy of malignant tumor, Biomater. Sci. 2021, 9, 6915-6926.207.pdf

    206N. Yu, Y.F. Zhang, J.Y. Li, W.X. Gu, S.J. Yue, B. Li, F.H. Meng, H.L. Sun*, R. Haag, J.D. Yuan, and Z.Y. Zhong*, Daratumumab Immunopolymersome-Enabled Safe and CD38-Targeted Chemotherapy and Depletion of Multiple Myeloma, Adv. Mater. 2021, 2007787.206.pdf

    205Z. Wang, F.H. Meng, and Z.Y. Zhong*, Emerging targeted drug delivery strategies toward ovarian cancer, Adv. Drug Deliv. Rev. 2021, 113969.205.pdf

    204S.P. Cao,Y.F. Xia,J.X. Shao,B.B. Guo,Y.Y. Dong,I.A. B. Pijpers, Z.Y. Zhong, F.H. Meng*, L.K.E.A. Abdelmohsen, D.S. Williams*, and J. C.M. van Hest*, Biodegradable Polymersomes with Structure Inherent Fluorescence and Targeting Capacity for Enhanced Photo-Dynamic Therapy, Angew. Chem. Int. Ed.  2021, 60, 17629-17637.204.pdf

    203Y.H. Wei, Y.P. Sun, J.J. Wei, X.Y. Qiu, F.H. Meng*, G. Storm*, J.D. Yuan, Z.Y. Zhong*, Selective transferrin coating as a facile strategy to fabricate BBB-permeable and targeted vesicles for potent RNAi therapy of brain metastatic breast cancer in vivo, J. Control. Release 2021, 337,  521-529.203.pdf

    202W.X. Gu, R.B. Qu, F.H. Meng*,J.L.M. Cornelissen*, and Z.Y. Zhong*, Polymeric Nanomedicines Targeting Hematological Malignancies, J. Control. Release 2021, 337, 571-588.202.pdf

    201Y.F. Xia, J.J. Wei, S.S. Zhao, B.B. Guo, F.H. Meng*, B. Klumperman, and Z.Y. Zhong*, Systemic administration of polymersomal oncolytic peptide LTX-315 combining with CpG adjuvant and anti-PD-1 antibody boosts immunotherapy of melanoma, J. Control. Release 2021, 336, 262-273.201.pdf

    200J. Ouyang, Y. Jiang, C. Deng, Z.Y. Zhong*, and Q. Lan*, Doxorubicin Delivered via ApoE-Directed Reduction-Sensitive Polymersomes Potently Inhibit Orthotopic Human Glioblastoma Xenografts in Nude Mice, Int. J. Nanomed. 2021, 16, 4105-4115.200.pdf

    199Z.Y. Zhong*, Controlled delivery systems are the cornerstone of advanced therapies and vaccines: An Asian perspective, J. Control. Release 2021, 334, 34-3.199.pdf

    198Z. Wang, S.S. Zhao, W.X. Gu, Y.Y. Dong, F.H. Meng*, J.D. Yuan, and Z.Y. Zhong*,α3 integrin-binding peptide-functionalized polymersomes loaded with volasertib for dually-targeted molecular therapy for ovarian cancer, Acta Biomaterialia 2021, 124, 348-357.198.pdf

    197Q.Y. Fan, Y.Y. Liu, G.H. Cui, Z.Y. Zhong*, and C. Deng*, Brain delivery of Plk1 inhibitor via chimaeric polypeptide polymersomes for safe and superb treatment of orthotopic glioblastoma, J. Control. Release2021, 329, 1139-1149.197.pdf

    196W.X. Gu, T.H. Liu, D.Y. Fan, J.B. Zhang, Y.F. Xia, F.H. Meng*, Y. Xu*, J.L.M. Cornelissen, Z.J. Liu, and Z.Y. Zhong*, A6 peptide-tagged, ultra-**all and reduction-sensitive polymersomal vincristine sulfate as a **art and specific treatment for CD44+ acute myeloid leukemia, J. Control. Release 2021, 329, 706-716.196.pdf

    195W.X. Gu, F.H. Meng*, R. Haag, and Z.Y. Zhong*, Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation, J. Control. Release 2021, 329, 676-695.195.pdf

    194J. Zhang, X.X. Wang, L. Cheng*, J.D. Yuan and Z.Y. Zhong*, SP94 Peptide Mediating Highly Specific and Efficacious Delivery of Polymersomal Doxorubicin Hydrochloride to Hepatocellular Carcinoma in Vivo, Colloids Surf. B: Biointerfaces 2021, 197, 111399.194.pdf


  • 2020

    193H.Y. Wang, X.H. Zhang, Y. Zhang*, R. Cheng*, J.D. Yuan, and Z.Y. Zhong*, Systemic Delivery of NAC-1 siRNA by Neuropilin-Targeted Polymersomes Sensitizes Antiangiogenic Therapy of Metastatic Triple Negative Breast Cancer, Biomacromolecules 2020, 21, 5119-5127.193.pdf

    192C. Gao, Q. Cheng, J.W. Wei, C. Sun, S.Y. Lu, C.H.T. Kwong, S.M.Y. Lee, Z.Y. Zhong*, and R.B. Wang*, Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery, Mater. Today 2020, 40, 9-17.192.pdf

    191C. Deng*, Q. Zhang, J.Q. Guo, X.F. Zhao, and Z.Y. Zhong*, Robust and **art polypeptide-based nanomedicines for targeted tumor therapy, Adv. Drug Deliv. Rev. 2020, 160, 199-211. 191.pdf

    190C.J. Zhang, X.X. Wang, R. Cheng*, and Z.Y. Zhong*, A6 Peptide-Tagged Core-Disulfide-Crosslinked Micelles for Targeted Delivery of Proteasome Inhibitor Carfilzomib to Multiple Myeloma in Vivo, Biomacromolecules 2020, 21, 2049-2059.190.pdf

    189C. Zhou, Y.F. Xia, Y.H. Wei, L.Cheng*, J.J. Wei, B.B. Guo, F,H. Meng*, S.P. Cao, J.C.M. van Hest, and Z.Y. Zhong*, GE11 peptide-installed chimaeric polymersomes tailor-made for high-efficiency EGFR-targeted protein therapy of orthotopic hepatocellular carcinoma, Acta Biomaterialia 2020, 113, 512-521.189.pdf

    188H.L. Sun, and Z.Y. Zhong*, 100th Anniversary of Macromolecular Science Viewpoint: Biological Stimuli-Sensitive Polymer Prodrugs and Nanoparticles for Tumor-Specific Drug Delivery, ACS Macro Lett. 2020, 9, 1292-1302.188.pdf

    187X.X. Wang, M. Qiu, C. Deng, R. Cheng*, and Z.Y. Zhong*, Targeted and Reduction-Sensitive Crosslinked PLGA Nanotherapeutics for Safer and Enhanced Chemotherapy of Malignant Melanoma, ACS Biomater. Sci. Eng. 2020, 6, 2621-2629.187.pdf

    186.S. Li, M. Qiu, J.K. Guo, Z.Y. Zhong*, and C. Deng*, Coating-Sheddable CD44-Targeted PLGA Nanomedicines Fabricated Using Photo-Click-Crosslinkable Hyaluronic Acid-graft-Tetrazole Conjugate as a Surfactant, Adv. Therapeutics 2020, 3, 1900160.186.pdf

    185Y. Zou, Y.P. Sun, Y.H. Wei, Y.F. Xia, Z.Y. Huangfu, F.H. Meng*, J. van Hest, and Z.Y. Zhong*,Alfa3beta1 Integrin-Targeting Polymersomal Docetaxel as an Advanced Nanotherapeutics for Non-Small Cell Lung Cancer Treatment, ACS Appl. Mater. Interfaces 2020, 12 , 14905-14913.185.pdf

    184Y.W. Li, J.J. Wei, Y.H. Wei, L. Cheng*, B.B. Guo, F.H. Meng*, F. Li, and Z.Y. Zhong*, Apolipoprotein E Peptide-Guided Disulfide-Crosslinked Micelles for Targeted Delivery of Sorafenib to Hepatocellular Carcinoma,Biomacromolecules 2020, 21, 716-724.184.pdf

    183H.M. Fang, X.F. Zhao, X.L. Gu, H.L. Sun, R. Cheng, Z.Y. Zhong*, and C. Deng*, CD44-Targeted Multifunctional Nanomedicines Based on a Single-Component Hyaluronic Acid Conjugate with All-Natural Precursors: Construction and Treatment of Metastatic Breast Tumors in Vivo, Biomacromolecules 2020, 21, 104-113.183.pdf

    182Y.H. Wei, F.H. Meng*, G. Storm, and Z.Y. Zhong*, Transferrin-Binding Peptide Functionalized Polymersomes Mediate Targeted Doxorubicin Delivery to Colorectal Cancer In Vivo, J. Control. Release 2020, 319, 407-415.182.pdf

    181.Y.N. Zhong, F.H. Meng*, W. Zhang, B. Li, J. van Hest, and Z.Y. Zhong*, CD44-Targeted Vesicles Encapsulating Granzyme B as Artificial Killer Cells for Potent Inhibition of Human Multiple Myeloma in Mice, J. Control. Release 2020, 320, 421-430.181.pdf





  • 2019

    180Y. Yan, Y.Y. Dong, S.J. Yue, X.Y. Qiu, H.L. Sun*, and Z.Y. Zhong*, Dually Active Targeting Nanomedicines Based on a Direct Conjugate of Two Purely Natural Ligands for Potent Chemotherapy of Ovarian Tumor, ACS Appl. Mater. Interfaces 2019, 11, 46548-46557.180.pdf

    179H.L. Sun, X.L. Gu, Q. Zhang, H. Xu, Z.Y. Zhong*, and C. Deng*, Cancer Nanomedicines Based on Synthetic Polypeptides, Biomacromolecules 2019, 20, 4299-4311.179.pdf


    178L. Ding, W.X. Gu, Y.F. Zhang, S.J. Yue, H.L. Sun*, J. Cornelissen, and Z.Y. Zhong*, HER2-Specific Reduction-Sensitive Immunopolymersomes with High Loading of Epirubicin for Targeted Treatment of Ovarian Tumor, Biomacromolecules 2019, 20, 3855-3863.178.pdf


    177Y. Zou, Y.H. Wei, J. Bao, F.R. Yao, Z.K. Li, Y.P. Sun, F.H. Meng*, C.H. Hu, G. Storm, and Z.Y. Zhong*, Cyclic RGD-Functionalized and Disulfide-Crosslinked Iodine-Rich Polymersomes as a Robust and Smart Theranostic Agent for Targeted CT Imaging and Chemotherapy of Melanoma, Theranostics 2019, 9, 8061-8072.177.pdf


    176. W.X. Gu, J.N. An, H. Meng, N. Yu, Y.N. Zhong, F.H. Meng*, Y. Xu*, J.L.M. Cornelissen, and Z.Y. Zhong*, CD44-Specific A6 Short Peptide Boosts Targetability and Anticancer Efficacy of Polymersomal Epirubicin to Orthotopic Human Multiple Myeloma, Adv. Mater. 2019, 1904742.176.pdf


    175.  X. Gu, Z. Zhu, Q. Fan, Y. Wei, G. Wang, F. Meng, Z. Zhong, C. Deng, Nanoagents based on poly(ethylene glycol)-b-poly(l-thyroxine) block copolypeptide for enhanced dual-modality imaging and targeted tumor radiotherapy. Small 2019, 0, 1902577.  175.pdf

    174.  S. Cao, J. Shao, Y. Xia, H. Che, Z. Zhong, F. Meng, J. C. M. van Hest, L. K. E. A. Abdelmohsen, D. S. Williams, Molecular programming of biodegradable nanoworms via ionically induced morphology switch toward asymmetric therapeutic carriers. Small 2019, 15, 1901849. 174.pdf

    173. H.L. Sun, Z.Y. Zhong*, and J. Feijen, The Fifth Symposium on Innovative Polymers for Controlled Delivery, September 14-17, 2018, Suzhou, China, J. Control. Release 2019, 307, 410-412.173.pdf


    172. H.Z. Qin, Y. Jiang, J. Zhang, C. Deng*, and Z.Y. Zhong*, Oncoprotein Inhibitor Rigosertib Loaded in ApoE-Targeted Smart Polymersomes Reveals a High Safety and Potency against Human Glioblastoma in Mice, Mol. Pharmaceutics 2019, 16, 3711-3719.172.pdf

    171. M. Qiu, J. Ouyang, Y.H. Wei, J. Zhang, Q. Lan, C. Deng*, and Z.Y. Zhong*, Selective cell penetrating peptide-functionalized envelope-type chimaeric lipopepsomes boost systemic RNAi therapy for lung tumor, Adv. Healthcare Mater. 2019, 1900500. 171.pdf

    170. Y. Wei, X. Gu, L. Cheng, F. Meng, G. Storm, Z. Zhong, Low-toxicity transferrin-guided polymersomal doxorubicin for potent chemotherapy of orthotopic hepatocellular carcinoma in vivo. Acta Biomater. 2019, 92, 196-204.170.pdf

    169.  K. Huang, Y. He, Z. Zhu, J. Guo, G. Wang, C. Deng, Z. Zhong, Small, traceable, endosome-disrupting, and bioresponsive click nanogels fabricated via microfluidics for CD44-targeted cytopla**ic delivery of therapeutic proteins. ACS Appl. Mater. Inter. 2019, 11, 22171-22180.169.pdf

    168.  M. Qiu, J. Ouyang, Y. Wei, J. Zhang, Q. Lan, C. Deng, Z. Zhong, Selective cell penetrating peptide-functionalized envelope-type chimeric lipopepsomes boost systemic RNAi therapy for lung tumors. Adv. Healthcare Mater. 2019, 0, 1900500.168.pdf

    167. J. S. Cao, Y. H. Wei, Y. X. Zhang, G. L. Wang, X. Ji, Z. Y. Zhong, Iodine-rich polymersomes enable versatile spect/ct imaging and potent radioisotope therapy for tumor in vivo. ACS Appl. Mater. Inter. 2019, 11, 18953-18959.167.pdf

    166. X. Gu, Y. Wei, Q. Fan, H. Sun, R. Cheng, Z. Zhong, C. Deng, cRGD-decorated biodegradable polytyrosine nanoparticles for robust encapsulation and targeted delivery of doxorubicin to colorectal cancer in vivo. J. Control. Release 2019, 301, 110-118.166.pdf

    165. D. Kuraitis, K. Hosoyama, N. J. R. Blackburn, C. Deng, Z. Zhong, E. J. Suuronen, Functionalization of soft materials for cardiac repair and regeneration. Crit. Rev. Biotechnol. 2019, 39, 451-468.165.pdf

    164. S. Lecommandoux, H.-A. Klok, Z. Zhong, T. J. Deming, Future directions at the frontier of polymer science and biology. Biomacromolecules 2019, 20, 1-3.164.pdf

    163. Q. Wang, Y. Zhong, W. Liu, Z. Wang, L. Gu, X. Li, J. Zheng, H. Du, Z. Zhong, F. Xie, Enhanced chemotherapeutic efficacy of the low-dose doxorubicin in breast cancer via nanoparticle delivery system crosslinked hyaluronic acid. Drug Deliv. 2019, 26, 12-22. 163.pdf

    162. N. Rades, K. Achazi, M. Qiu, C. Deng, R. Haag, Z.Y. Zhong*, and K. Licha*, Reductively cleavable polymer-drug conjugates based on dendritic polyglycerol sulfate and monomethyl auristatin E as anticancer drugs, J. Control. Release 2019, 300, 13-21.162.pdf

    161. X. Xu, W.J. Yang, Y.N. Shi, W.X. Zhang, X. Wang, F.H. Meng, and Z.Y. Zhong*, and L.C. Yin*, Efficient and Targeted Drug/siRNA Co-Delivery Mediated by Reversibly Crosslinked Polymersomes toward Anti-Inflammatory Treatment of Ulcerative Colitis (UC), Nano Res. 2019, 12, 659-667.161.pdf

    160. J. Chen, H. He, C. Deng*, L.C. Yin, and Z.Y. Zhong*, Saporin-Loaded CD44 and EGFR Dual-Targeted Nanogels for Potent Inhibition of Metastatic Breast Cancer In Vivo, Int. J. Pharmaceutics 2019, 560, 57-64.160.pdf

    159. P.L. Yao, Y.F. Zhang, H. Meng, H.L. Sun*, and Z.Y. Zhong*, Smart polymersomes dually functionalized with cRGD and fusogenic GALA peptides enable specific and high-efficiency cytosolic delivery of apoptotic proteins, Biomacromolecules 2019, 20, 184-191.159.pdf

  • 2018

    158. Y. Zou, J.J. Wei, Y.F. Xia, F.H. Meng*, J.D. Yuan, and Z.Y. Zhong*, Targeted chemotherapy for subcutaneous and orthotopic non-**all cell lung tumors with cyclic RGD-functionalized and disulfide-crosslinked polymersomal doxorubicin, Signal Transduction and Targeted Therapy 2018, 3, 32.158.pdf

    157. I.A.B. Pijpers, L.K.E.A. Abdelmohsen, Y.F. Xia, S.P. Cao, D.S. Williams, F.H. Meng*, J.C.M. van Hest*, and Z.Y. Zhong*, Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies, Adv. Therapeutics 2018, 1, 1800068.157.pdf

    156. H.L. Sun, Y.F. Zhang, and Z.Y. Zhong*, Reduction-Sensitive Polymeric Nanomedicines: An Emerging Multifunctional Platform for Targeted Cancer Therapy, Adv. Drug Deliv. Rev. 2018, 132, 16-32.156.pdf

    155. M. Qiu, Z.Q. Zhang, Y.H. Wei, H.L. Sun, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Small-Sized and Robust Chimaeric Lipopepsomes: A Simple and Functional Platform with High Protein Loading for Targeted Intracellular Delivery of Protein Toxin In Vivo, Chem. Mater. 2018, 30, 6831-6838.155.pdf

    154. Z.X. Gu, X.X. Wang, R. Cheng*, L. Cheng, and Z.Y. Zhong*, Hyaluronic acid shell and disulfide-crosslinked core micelles for in vivo targeted delivery of bortezomib for the treatment of multiple myeloma, Acta Biomaterialia 2018, 80, 288-295.154.pdf

    153. T.J. Deming, H.-A. Klok, S.P. Armes, M.L. Becker, J.A. Champion, E.Y.-X. Chen, S.C. Heilshorn, J.C. M. van Hest,.D.J. Irvine, J.A. Johnson, L.L. Kiessling, H.D. Maynard, M.O. de la Cruz, M.O. Sullivan, M.V. Tirrell, K.S. Anseth, S. Lecommandoux, S. Percec, Z.Y. Zhong, A.-C. Albertsson, Polymers at the Interface with Biology,Biomacromolecules 2018, 19, 3151-3162.153.pdf

    152. Y. Zhang, K.Q. Wu, H.L. Sun*, J. Zhang, J.D. Yuan, and Z.Y. Zhong*, Hyaluronic acid-shelled disulfide-crosslinked nano-polymersomes for ultrahigh-efficiency reactive encapsulation and CD44-targeted delivery of mertansine toxin, ACS Appl. Mater. Interfaces 2018, 10, 1597-1604.152.pdf

    151. Y. Jiang, J. Zhang*, F.H. Meng, and Z.Y. Zhong*, Apolipoprotein E Peptide-Directed Chimeric Polymersomes Mediate an Ultrahigh-Efficiency Targeted Protein Therapy for Glioblastoma, ACS Nano 2018, 12, 11070-11079.151.pdf

    150. L. Cheng, Y. Yang, F.H. Meng*, Z.Y. Zhong*, Protein Nanotherapeutics as an Emerging Modality for Cancer Therapy, Adv. Healthcare Mater. 2018, 7, 1800685.

    149. M. Qiu, X.X. Wang, H.L. Sun, J. Zhang, C. Deng*, and Z.Y. Zhong*, Cyclic RGD Peptide-Functionalized Polylipopeptide Micelles for Enhanced Loading and Targeted Delivery of Monomethyl Auristatin E, Mol. Pharmaceutics 2018, 15, 4854-4861.149.pdf

    148. Y.N. Shi, Y. Jiang, J.S. Cao, W.J. Yang, J. Zhang*, F.H. Meng, and Z.Y. Zhong*, Boosting RNAi therapy for orthotopic glioblastoma with nontoxic brain-targeting chimaeric polymersomes, J. Control. Release 2018, 292, 163-171.148.pdf

    147. W.J. Yang, Y.H. Wei, J. Zhang, Z.Y. Zhong*, F.H. Meng*, Granzyme B-loaded, cell-selective penetrating and reduction-responsive polymersomes effectively inhibit progression of orthotopic human lung tumor in vivo, J. Control. Release 2018, 290, 141-149.147.pdf

    146. H.L. Sun, Y.Y. Dong, J. Feijen*, and Z.Y. Zhong*, Peptide-Directed Polymeric Nanomedicines for Precision Cancer Therapy, J. Control. Release 2018, 290, 11-27.146.pdf

    145. Y. Zou, Y.F. Xia, F.H. Meng*, J. Zhang, and Z.Y. Zhong*, GE11-Directed Functional Polymersomal Doxorubicin as an Advanced Alternative to Clinical Liposomal Formulation for Ovarian Cancer Treatment, Mol. Pharmaceutics 2018, 15, 3664-3671.145.pdf

    144. Y. Jiang, W.J. Yang, J. Zhang*, F.H. Meng, and Z.Y. Zhong*, Protein Toxin Chaperoned by LRP-1 Targeted Virus-Mimicking Vesicles Induces High-Efficiency Glioblastoma Therapy In Vivo, Adv. Mater. 2018, 30, 1800316.

    143. D.C. Huang, H.L. Qian, H.S., Qiao, W. Chen*, J. Feijen, and Z.Y. Zhong*, Bioresponsive Functional Nanogels as An Emerging Platform for Cancer Therapy, Expert Opin. Drug Deliv. 2018, 15, 703-716.

    142. S. Xue, X.L. Gu, J. Zhang, H.L. Sun, C. Deng*, and Z.Y. Zhong*, Construction of Small-Sized, Robust and Reduction-Responsive Polypeptide Micelles for High Loading and Targeted Delivery of Chemotherapeutics, Biomacromolecules 2018, 19, 3586-3593.142.pdf

    141. H.L. Sun, H.A. Klok*, and Z.Y. Zhong*, Polymers  from Nature and for Nature, Biomacromolecules 2018, 19,  1697-1700. 141.pdf

    140. J.J. Wei, M. Meng, B.B. Guo, Z.Y. Zhong*, and F.H. Meng*,  Organocatalytic ring-opening copolymerization of trimethylene carbonate and  dithiolane trimethylene carbonate: Impact of organocatalysts on copolymerization  kinetics and copolymer  microstructures, Biomacromolecules 2018, 19,  2294-2301. 140.pdf

    139. W.J. Yang, Y.F. Xia, Y.  Fang, F.H. Meng*, J. Zhang, R.  Cheng, C. Deng, and Z.Y. Zhong*, Selective  Cell Penetrating Peptide-Functionalized Polymersomes Mediate Efficient and  Targeted Delivery of Methotrexate Disodium to Human Lung Cancer In  Vivo, Adv. Healthcare Mater. 2018, 7, 1701135.

    138. Y.Q. Zhu, J. Zhang,  F.H. Meng,  L.  Cheng*, J.  Feijen*, and Z.Y.  Zhong*, Reduction-Responsive Core-Crosslinked Hyaluronic  Acid-b-Poly(Trimethylene Carbonate-co-Dithiolane Trimethylene Carbonate)  Micelles: Synthesis and CD44-Mediated Potent Delivery of Docetaxel to Triple  Negative Breast Tumor In Vivo, J. Mater. Chem. B 2018, 6,  3040-3047.138.pdf

    137. X.L. Gu, M. Qiu, H.L. Sun, J. Zhang, L. Cheng, C. Deng*, and  Z.Y.  Zhong*, Polytyrosine nanoparticles enable ultra-high loading of doxorubicin  and rapidly enzyme-responsive drug release, Biomater.Sci.  2018, 6, 1526-1534.137.pdf

    136. X.X. Wang, R. Cheng*, L. Cheng, and Z.Y. Zhong*, Lipoyl ester terminated star PLGA as a simple and **art material for controlled drug delivery application, Biomacromolecules 2018, 19, 1368-1373. 136.pdf

    135. Y.Q. Zhu, Y. Jiang, F.H. Meng, C. Deng, R. Cheng, J. Zhang*, J. Feijen*, and Z.Y. Zhong*, Highly efficacious and specific anti-glioma chemotherapy by **art tandem nanomicelles co-functionalized with brain tumor-targeting and cell-penetrating peptides, J. Control. Release 2018, 278, 1-8.

    134. W.J. Yang, Y.F. Xia, L. Cheng*, J. Zhang, F.H. Meng*, J.D. Yuan, and Z.Y. Zhong*, Lung cancer specific and reduction-responsive chimaeric polymersomes for highly efficient loading of pemetrexed and targeted suppression of lung tumor in vivo, Acta Biomaterialia 2018, 70, 177-185. 134.pdf

    133. Qiu M, Sun H, Meng F, et al. Lipopepsomes: A novel and robust family of nano-vesicles capable of highly efficient encapsulation and tumor-targeted delivery of doxorubicin hydrochloride in vivo. Journal of Controlled Release, 2018, 272: 107-113.

    132. Zhong Z, Chen T, Qiu M, et al. Integrated Multifunctional Micelles Co‐Self‐Assembled from Polypeptides Conjugated with Natural Ferulic Acid and Lipoic Acid for Efficient and Bioresponsive Doxorubicin Delivery. ChemPhysChem, 2018.

    131. Zhu Y, Feijen J, Zhong Z. Dual-targeted nanomedicines for enhanced tumor treatment. Nano Today, 2018.131.pdf

    130. Chen J, Huang K, Chen Q, et al. Tailor-Making Fluorescent Hyaluronic Acid Microgels via Combining Microfluidics and Photoclick Chemistry for Sustained and Localized Delivery of Herceptin in Tumor. ACS applied materials & interfaces, 2018.130.pdf

    129. Ding L, Jiang Y, Zhang J, et al. pH-Sensitive Coiled-Coil Peptide-Crosslinked Hyaluronic Acid Nanogels: Synthesis and Targeted Intracellular Protein Delivery to CD44 Positive Cancer Cells. Biomacromolecules, 2017. 129.pdf

  • 2017

    128. Yang W, Xia Y, Fang Y, et al. Selective Cell Penetrating Peptide‐Functionalized Polymersomes Mediate Efficient and Targeted Delivery of Methotrexate Disodium to Human Lung Cancer In Vivo. Advanced healthcare materials, 2017.


    127. P. Zhong, M. Qiu, J. Zhang, H.L. Sun, R. Cheng*, C. Deng, F.H. Meng, and Z.Y. Zhong*, cRGD-Installed Docetaxel-Loaded Mertansine Prodrug Micelles: Redox-Triggered Ratiometric Dual Drug Release and Targeted Synergistic Treatment of B16F10 Melanoma, Nanotechnology 2017, 28, 295103.127.pdf


    126. Y. Fang, W. Yang, L. Cheng, F. Meng, J. Zhang, Z. Zhong, EGFR-targeted multifunctional polymersomal doxorubicin induces selective and potent suppression of orthotopic human liver cancer in vivo, Acta Biomater, 64 (2017) 323-333. 126.pdf

      

    125. Z. Zhong, Innovative Polymers for Controlled Release Applications, Biomacromolecules, 18 (2017) 3652-3653. 125.pdf

      

    124. W. Yang, Y. Xia, Y. Zou, F. Meng, J. Zhang, Z. Zhong, Bioresponsive Chimaeric Nanopolymersomes Enable Targeted and Efficacious Protein Therapy for Human Lung Cancers in Vivo, Chemistry of Materials, 29 (2017) 8757-8765. 124.pdf

      

    123. C. Hang, Y. Zou, Y. Zhong, Z. Zhong, F. Meng, NIR and UV-responsive degradable hyaluronic acid nanogels for CD44-targeted and remotely triggered intracellular doxorubicin delivery, Colloids and Surfaces B: Biointerfaces, 158 (2017) 547-555. 123.pdf

      

    122. Y. Zhu, J. Zhang, F. Meng, C. Deng, R. Cheng, J. Feijen, Z. Zhong, cRGD/TAT Dual-Ligand Reversibly Cross-Linked Micelles Loaded with Docetaxel Penetrate Deeply into Tumor Tissue and Show High Antitumor Efficacy in Vivo, ACS Appl Mater Interfaces, 9 (2017) 35651-35663. 122.pdf

      

    121. Y. Zou, M. Zheng, W. Yang, F. Meng, K. Miyata, H.J. Kim, K. Kataoka, Z. Zhong, Virus-Mimicking Chimaeric Polymersomes Boost Targeted Cancer siRNA Therapy In Vivo, Advanced Materials, 29 (2017) 1703285.121.pdf

      

    120. M. Qiu, J. Ouyang, H. Sun, F. Meng, R. Cheng, J. Zhang, L. Cheng, Q. Lan, C. Deng, Z. Zhong, Biodegradable Micelles Based on Poly(ethylene glycol)-b-polylipopeptide Copolymer: A Robust and Versatile Nanoplatform for Anticancer Drug Delivery, ACS Appl Mater Interfaces, 9 (2017) 27587-27595. 120.pdf

      

    119. N.J.R. Blackburn, B. Vulesevic, B. McNeill, C.E. Cimenci, A. Ahmadi, M. Gonzalez-Gomez, A. Ostojic, Z. Zhong, M. Brownlee, P.J. Beisswenger, R.W. Milne, E.J. Suuronen, Methylglyoxal-derived advanced glycation end products contribute to negative cardiac remodeling and dysfunction post-myocardial infarction, Basic Research in Cardiology, 112 (2017). 119.pdf

      

    118. J. Chen, J. Ouyang, Q. Chen, C. Deng, F. Meng, J. Zhang, R. Cheng, Q. Lan, Z. Zhong, EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo, ACS Appl Mater Interfaces, 9 (2017) 24140-24147. 118.pdf

      

    117. J. Qiu, R. Cheng, J. Zhang, H. Sun, C. Deng, F. Meng, Z. Zhong, Glutathione-Sensitive Hyaluronic Acid-Mercaptopurine Prodrug Linked via Carbonyl Vinyl Sulfide: A Robust and CD44-Targeted Nanomedicine for Leukemia, Biomacromolecules, 18 (2017) 3207-3214. 117.pdf

      

    116. H. Meng, Y. Zou, P. Zhong, F. Meng, J. Zhang, R. Cheng, Z. Zhong, A Smart Nano-Prodrug Platform with Reactive Drug Loading, Superb Stability, and Fast Responsive Drug Release for Targeted Cancer Therapy, Macromol Biosci, 17 (2017) 1600518.


    115. P. Zhong, X. Gu, R. Cheng, C. Deng, F. Meng, Z. Zhong, αvβ3 integrin-targeted micellar mertansine prodrug effectively inhibits triple-negative breast cancer in vivo, Int J Nanomedicine, Volume 12 (2017) 7913-7921. 115.pdf

      

    114. Y. Zhu, X. Wang, J. Zhang, F. Meng, C. Deng, R. Cheng, J. Feijen, Z. Zhong, Exogenous vitamin C boosts the antitumor efficacy of paclitaxel containing reduction-sensitive shell-sheddable micelles in vivo, Journal of Controlled Release, 250 (2017) 9-19. 114.pdf

      

      

    113. K. Wu, R. Cheng, J. Zhang, F. Meng, C. Deng, Z. Zhong, Micellar nanoformulation of lipophilized bortezomib: high drug loading, improved tolerability and targeted treatment of triple negative breast cancer, Journal of Materials Chemistry B, 5 (2017) 5658-5667. 113.pdf

      

    112. Y. Zhong, F. Meng, C. Deng, X. Mao, Z. Zhong, Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in **art lipoic acid-crosslinked hyaluronic acid nanoparticles, Drug Delivery, 24 (2017) 1482-1490.  112.pdf

      

    111. J.T. Wu, J. Zhang, C. Deng*, F.H. Meng, R. Cheng, and Z.Y. Zhong*, Robust, Responsive and Targeted PLGA Anticancer Nanomedicines by Combining Reductively Cleavable Surfactant and Covalent Hyaluronic Acid Coating, ACS Appl. Mater. Interfaces 2017, DOI: 10.1021/acsami.6b15105   111.pdf

      

    110. Y. Fang, Y. Jiang, Y. Zou, F.H. Meng*, J. Zhang, C. Deng, H.L. Sun and Z.Y. Zhong*, Targeted glioma chemotherapy by cyclic RGD peptide-functionalized reversibly core-crosslinked multifunctional poly(ethylene glycol)-b-poly(e-caprolactone) micelles, Acta Biomaterialia 2017, http://dx.doi.org/10.1016/j.actbio.2017.01.007   110.pdf

      

    109. J.T. Wu, C. Deng*, F.H. Meng, J. Zhang, H.L. Sun, and Z.Y. Zhong*, Hyaluronic acid coated PLGA nanoparticulate docetaxel effectively targets and suppresses orthotopic human lung cancer, J. Control. Release 2017,  http://dx.doi.org/10.1016/j.jconrel.2016.12.024   109.pdf


    108. P. Zhong, H. Meng, J. Qiu, J. Zhang, H.L. Sun, R. Cheng*, and Z.Y. Zhong*,αvβ3 Integrin-Targeted Reduction-Sensitive Micellar Mertansine Prodrug: Superb Drug Loading, Enhanced Stability, and Effective Inhibition of Melanoma Growth In Vivo, J. Control. Release 2017,  DOI: 10.1016/j.jconrel.2016.12.011  108.pdf


    107. Y. Zou, Y.H. Wei, G.L. Wang, F.H. Meng*, M.Y. Gao, G. Storm, and Z.Y. Zhong*, Nano-Polymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo, Adv. Mater. 2017, http://dx.doi.org/10.1002/adma.201603997  107.pdf


    106. W. Chen, Y. Zou, Z.Y. Zhong*, and R. Haag *, Cyclo(RGD)-decorated Redox-responsive Nanogels Mediate Targeted Chemotherapy of Integrin Over-expressing Human Glioblastoma In Vivo, Small 2017, DOI: 10.1002/**ll.201601997  106.pdf


    105. N. Zhang, Y.F. Xia, Y. Zou, W.J. Yang, J. Zhang, Z.Y. Zhong*, and F.H. Meng*, ATN-161 Peptide Functionalized Reversibly Crosslinked Polymersomes Mediate Targeted Doxorubicin Delivery into Melanoma-Bearing C57BL/6 Mice, Mol. Pharm. 2017, DOI: 10.1021/acs.molpharmaceut.6b00800  105.pdf

  • 2016

    104. J. Chen, Y. Zou, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Multifunctional Click Hyaluronic Acid Nanogels for Targeted Protein Delivery and Effective Cancer Treatment In Vivo, Chem. Mater. 2016, 28, 8792-8799.  104.pdf

    103. P. Zhong, J. Zhang, C. Deng, R. Cheng*, F.H. Meng, and Z.Y. Zhong*, Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy, Biomacromolecules 2016, 17, 3602-3608.   103.pdf

    102. Y.N. Zhong, M. Dimde, D. Stöbener, F.H. Meng*, C. Deng, Z.Y. Zhong*, and R. Haag, Micelles with Sheddable Dendritic Polyglycerol Sulfate Shells Show Extraordinary Tumor Targetability and Chemotherapy In Vivo, ACS Appl. Mater. Interfaces 2016, 8, 27530-27538.   102.pdf

    101. W.J. Yang, Y. Zou, F.H. Meng*, J. Zhang, R. Cheng, C. Deng, and Z.Y. Zhong*, Efficient and targeted suppression of human lung tumor xenografts in mice with methotrexate sodium encapsulated in all-function-in-one chimaeric polymersomes, Adv. Mater. 2016, 28, 8234-8239.   101.pdf

    100. Y.Q. Zhu, X.X. Wang, J. Chen, J. Zhang, F.H. Meng, C. Deng, R. Cheng, J. Feijen*, and Z.Y. Zhong*, Bioresponsive and fluorescent hyaluronic acid-iodixanol nanogels for targeted X-ray computed tomography imaging and chemotherapy of breast tumors, J. Control. Release 2016, 244, 229-239.   100.pdf

    99. Y. Zou, F.H. Meng*, C. Deng, and Z.Y. Zhong*, Robust, tumor-homing and redox-sensitive polymersomal doxorubicin: A superior alternative to Doxil and Caelyx? J. Control. Release 2016, 239, 149-158.   99.pdf

    98. S. Li, J. Zhang, C. Deng*, F.H. Meng, L. Yu, and Z.Y. Zhong*, Redox-sensitive and intrinsically fluorescent photoclick hyaluronic acid nanogels for traceable and targeted delivery of cytochrome C to breast tumor in mice, ACS Appl. Mater. Interfaces 2016, 8, 21155-21162  98.pdf

    97. B.F. Sun, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Robust, active tumor-targeting and fast bioresponsive anticancer nanotherapeutics based on natural endogenous materials, Acta Biomaterialia 2016, 45, 223-233.   97.pdf

    96. J.T. Wu, J. Zhang, C. Deng*, F.H. Meng, and Z.Y. Zhong*, Vitamin E-Oligo(methyl diglycol L-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles, Biomacromolecules 2016, 17, 2367-2374   96.pdf

    95. Y. Zou, H. Meng, F.H. Meng*, C. Deng, J. Zhang, and Z.Y. Zhong*, Self-crosslinkable and intracellularly decrosslinkable biodegradable micellar nanoparticles: a robust, simple and multifunctional nanoplatform for high-efficiency targeted cancer chemotherapy, J. Control. Release 2016, 244, 326-335.   95.pdf

    94. Y.Q. Zhu, J. Zhang*, F.H. Meng, C. Deng, R. Cheng, J. Feijen*, and Z.Y. Zhong*, cRGD-functionalized reduction-sensitive shell-sheddable biodegradable micelles mediate enhanced doxorubicin delivery to human glioma xenografts in vivo, J. Control. Release 2016, 233, 29-38.   94.pdf

    93. X. Ma, Z.W. He, F.X. Han, Z.Y. Zhong*, L. Chen, and B. Li*, Preparation of collagen/hydroxyapatite/alendronate hybrid hydrogels as potential scaffolds for bone regeneration, Colloids Surf. B: Biointerfaces 2016, 143, 81-87.  93.pdf

    92. X.X. Wang, J. Zhang, R. Cheng*, F.H. Meng, C. Deng, and Z.Y. Zhong*, Facile synthesis of reductively degradable biopolymers using cystamine diisocyanate as a coupling agent, Biomacromolecules 2016, 17, 882-890.  92.pdf

    91. Y.N. Zhong, K. Goltsche, L. Cheng, F. Xie, F.H. Meng*, C. Deng, Z.Y. Zhong*, and R. Haag, Hyaluronic acid-shelled acid-activatable paclitaxel prodrug micelles effectively target and treat CD44-overexpressing human breast tumor xenografts in vivo, Biomaterials 2016, 84, 250-261.  91.pdf

  • 2015

    90. X. Li, W.J. Yang, Y. Zou, F.H. Meng*, C. Deng, and Z.Y. Zhong*, Efficacious delivery of protein drugs to prostate cancer cells by PSMA-targeted pH-responsive chimaeric polymersomes, J. Control. Release 2015, 220, 704-714. 

    89. R. Cheng, F.H. Meng, C. Deng, and Z.Y. Zhong*, Bioresponsive Polymeric Nanotherapeutics for Targeted Cancer Chemotherapy, Nano Today 2015, 10, 656-670.   89.pdf

    88. S.Y. Liu*, and Z.Y. Zhong*,  Preface - Special Topic: Progress in Synthetic Polymer Chemistry, SCIENCECHINAChemistry 2015, 58, 1631-1632.

    87. W.T. Lu, X.X. Wang, R. Cheng*, C. Deng, F.H. Meng, and Z.Y. Zhong*, Biocompatible and Bioreducible Micelles Fabricated from Novel α-Amino Acid-Based Poly(disulfide urethane)s: Design, Synthesis and Triggered Doxorubicin Release, Polymer Chemistry 2015, 6, 6001-6010.   87.pdf

    86. F.S. Huang, R. Cheng*, F.H. Meng, C. Deng, and Z.Y. Zhong*, Micelles Based on Acid Degradable Poly(acetal urethane): Preparation, pH-Sensitivity, and Triggered Intracellular Drug Release, Biomacromolecules 2015, 16, 2228-2236.  86.pdf

    85. L. Lu, Y. Zou, W.J. Yang, F.H. Meng*, C. Deng, R. Cheng, and Z.Y. Zhong*, Anisamide-Decorated pH-Sensitive Degradable Chimaeric Polymersomes Mediate Potent and Targeted Protein Delivery to Lung Cancer Cells, Biomacromolecules 2015, 16, 1726-1735   85.pdf

    84. W. Chen, F.H. Meng, R. Cheng, C. Deng, J. Feijen*, and Z.Y. Zhong*, Facile Construction of Dual-Bioresponsive Biodegradable Micelles with Superior Extracellular Stability and Activated Intracellular Drug Release, J. Control. Release 2015, 210, 125-133   84.pdf

    83. Z.Y. Zhong*, Professor Jan Feijen: a Pioneer in Biomedical Polymers and Controlled Drug Release, J. Control. Release 2015, 205, 3-6.   83.pdf

    82. Z.Y. Zhong*, and J. Feijen, The Third Symposium on Innovative Polymers for Controlled Delivery, September 16-19, 2014, Suzhou, China, J. Control. Release 2015, 205, 1-2.  82.pdf

    81. H. He, Y.G. Bai, J.H. Wang, Q.R. Deng, L.P. Zhu, F.H. Meng, Z.Y. Zhong*, and L.C. Yin*, Reversibly crosslinked polyplexes enable cancer-targeted gene delivery via self-promoted DNA release and self-diminished toxicity, Biomacromolecules 2015, 16, 1390-1400.   81.pdf

    80. P.P. Chen, M. Qiu, C. Deng*, F.H. Meng, J. Zhang, R. Cheng, and Z.Y. Zhong*, pH-Responsive Chimaeric Pepsomes Based on Asymmetric Poly(ethylene glycol)-b-Poly(L-leucine)-b-Poly(L-glutamic acid) Triblock Copolymer for Efficient Loading and Active Intracellular  Delivery of Doxorubicin Hydrochloride, Biomacromolecules 2015, 16, 1322-1330.   80.pdf

    79. J.L. Lv, H.L. Sun, Y. Zou, F.H. Meng*, A.A. Dias, M. Hendriks, J. Feijen, and Z.Y. Zhong*, Reductively Degradable a-Amino Acid-Based Poly(ester amide)-Graft-Galactose Copolymers: Facile Synthesis, Self-Assembly, and Hepatoma-Targeting Doxorubicin Delivery, Biomater. Sci. 2015, 3, 1134-1146.   79.pdf

    78. Y.N. Zhong, J. Zhang, R. Cheng*, C. Deng, F.H. Meng, F. Xie*, and Z.Y. Zhong*, Reversibly Crosslinked Hyaluronic Acid Nanoparticles for Active Targeting and Intelligent Delivery of Doxorubicin to Drug Resistant CD44+ Human Breast Tumor Xenografts, J. Control. Release 2015, 205, 144-154.  78.pdf

    77. W. Chen, F.H. Meng, R. Cheng, C. Deng, J. Feijen*, and Z.Y. Zhong*, Biodegradable Glycopolymer-b-Poly(e-caprolactone) Block Copolymer Micelles: Versatile Construction, Tailored Lactose Functionality, and Hepatoma-Targeted Drug Delivery, J. Mater. Chem. B 2015, 3, 2308-2317. 77.pdf

    76. H.L. Sun, R. Cheng, C. Deng, F.H. Meng*, A.A. Dias, M. Hendriks, J. Feijen, and Z.Y. Zhong*, Enzymatically and Reductively Degradable a-Amino Acid-Based Poly(ester amide)s: Synthesis, Cell Compatibility, and Intracellular Anticancer Drug Delivery, Biomacromolecules 2015, 16, 597-605.   76.pdf

    75. G.H. Xu, X.L. Wang, C. Deng*, X.M. Teng, E.J. Suuronen, Z.Y. Shen*, and Z.Y. Zhong*, Injectable Biodegradable Hybrid Hydrogels Based on Thiolated Collagen and Oligo(acryloyl carbonate)-Poly(ethylene glycol)-Oligo(acryloyl carbonate) Copolymer for Functional Cardiac Regeneration, Acta Biomaterialia 2015, 15, 55-64.   75.pdf

    74. N.J.R. Blackburn, T. Sofrenovic, D. Kuraitis, A. Ahmadi, B. McNeill, C. Deng, K.J. Rayner, Z.Y. Zhong, M. Ruel, and E.J. Suuronen*, Timing underpins the benefits associated with injectable collagen biomaterial therapy for the treatment of myocardial infarction, Biomaterials 2015, 39, 182-192.  74.pdf


  • 2014

    73. W. Chen, F.H. Meng, R. Cheng, C. Deng, J. Feijen*, and Z.Y. Zhong*, Advanced Drug and Gene Delivery Systems Based on Functional Biodegradable Polycarbonates and Copolymers, J. Control. Release 2014, 190, 398-414.   73.pdf

    72. Y.N. Zhong, C. Wang, R. Cheng, L. Cheng, F.H. Meng*, Z. Liu*, and Z.Y. Zhong*, cRGD-Directed, NIR-Responsive and Robust AuNR/PEG-PCL Hybrid Nanoparticles for Targeted Chemotherapy of Glioblastoma In Vivo, J. Control. Release 2014, 195, 63-71.  72.pdf

    71. Y.N. Zhong, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy, Biomacromolecules 2014, 15, 1955-1969. 71.pdf

    70. Y. Zou, Y. Song, W.J. Yang, F.H. Meng*, H.Y.Liu, and Z.Y. Zhong*, Galactose-Installed Photo-Crosslinked pH-Sensitive Degradable Micelles for Active Targeting Chemotherapy of Hepatocellular Carcinoma in Mice, J. Control. Release 2014, 193, 154-161.  70.pdf

    69. Y.J. Jiang, J. Chen, C. Deng*, E. Suuronen, and Z.Y. Zhong*, Click Hydrogels, Microgels and Nanogels: Emerging Platforms for Drug Delivery and Tissue Engineering, Biomaterials  2014, 35, 4969-4985.   69.pdf

    68. C. Deng, J.T. Wu, R. Cheng, F.H. Meng, H.A. Klok, and Z.Y. Zhong*, Functional Polypeptide and Hybrid Materials: Precision Synthesis via α-Amino Acid N-Carboxyanhydride Polymerization and Emerging Biomedical Applications, Prog. Polym. Sci. 2014, 39, 330-364.   68.pdf

    67. W. Chen, Y. Zou, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Glyco-Nanoparticles with Sheddable Saccharide Shells: A Unique and Potent Platform for Hepatoma-Targeting Delivery of Anticancer Drugs, Biomacromolecules 2014, 15, 900-907.   67.pdf

    66. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction and pH Dual-Bioresponsive Crosslinked Polymersomes for Efficient Intracellular Delivery of Proteins and Potent Induction of Cancer Cell Apoptosis, Acta Biomaterialia 2014, 10, 2159-2168   66.pdf

    65. F.H. Meng, Y.N. Zhong, R. Cheng, C. Deng, and Z.Y. Zhong*, pH-Sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: Concept and recent advances, Nanomedicine 2014, 9, 487-499. (invited review) 

    64. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction-Responsive Polymeric Micelles and Vesicles for Triggered Intracellular Drug Release, Antioxidants & Redox Signaling 2014, 21, 755-767. (invited forum article)   64.pdf

    63. W.W. Guo, M. Zheng, Y.N. Zhong, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Poly(ethylene oxide)-graft-methotrexate Macromolecular Drugs Conjugating via Aminopteridine Ring Exhibit Potent Anticancer Activity, Chinese Journal of Chemistry 2014, 32, 57-65. 63.pdf

  • 2013

    62. Y.N. Zhong, W.J. Yang, H.L. Sun, R. Cheng, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Ligand-Directed Reduction-Sensitive Shell-Sheddable Biodegradable Micelles Actively Deliver Doxorubicin into the Nuclei of Target Cancer Cells, Biomacromolecules 2013, 14, 3723-3730. 62.pdf

    61. J.R. Zhou, P.P. Chen, C. Deng*, F.H. Meng, R. Cheng, and Z.Y. Zhong*, A Simple and Versatile Synthetic Strategy to Functional Polypeptides via Vinyl Sulfone-Substituted L-Cysteine N-Carboxyanhydride, Macromolecules 2013, 46, 6723–6730.  61.pdf

    60. Y.P. Fan, C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, In Situ Forming Hydrogels via Catalyst-Free and Bioorthogonal “Tetrazole–Alkene” Photo-Click Chemistry, Biomacromolecules 2013, 14, 2814-2821.  60.pdf

    59. X.Y. Wang, H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Galactose-Decorated Reduction-Sensitive Degradable Chimaeric Polymersomes as a Multifunctional Nanocarrier To Efficiently Chaperone Apoptotic Proteins into Hepatoma Cells, Biomacromolecules 2013, 14, 2873-2882.   59.pdf

    58. Y.D. Gu, Y.N. Zhong, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Acetal-Linked Paclitaxel Prodrug Micellar Nanoparticles as a Versatile and Potent Platform for Cancer Therapy, Biomacromolecules 2013, 14, 2772-2780.   58.pdf

    57. Y.N. Zhong, W. Wang, L. Cheng,  F.H. Meng, Z.Y. Zhong*, and Z. Liu*, Gold Nanorod-Cored Biodegradable Micelles as a Robust and Remotely Controllable Doxorubicin Release System for Potent Inhibition of Drug-Sensitive and -Resistant Cancer Cells, Biomacromolecules 2013, 14, 2411-2419.

    56. L.L. Wu, Y. Zou, C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Intracellular Release of Doxorubicin from Core-Crosslinked Polypeptide Micelles Triggered by Both pH and Reduction Conditions, Biomaterials 2013, 34, 5262-5272. 56.pdf

    55. W. Chen, M. Zheng, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, In Situ Forming Reduction-Sensitive Degradable Nanogels for Facile Loading and Triggered Intracellular Release of Proteins, Biomacromolecules 2013, 14, 1214-1222. 55.pdf

    54. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction-Sensitive Degradable Micellar Nanoparticles as Smart and Intuitive Delivery Systems for Cancer Chemotherapy, Expert Opin. Drug Deliv. 2013, 10, 1109-1122.  54.pdf 

    53. R. Cheng, F.H. Meng, C. Deng, H.A. Klok, and Z.Y. Zhong*, Dual and Multi-Stimuli Responsive Polymeric Nanoparticles for Programmed Site-Specific Drug Delivery, Biomaterials 2013, 34, 3647-3657.   53.pdf

    52. J. Feijen, and Z.Y. Zhong*, The Second Symposium on Innovative Polymers for Controlled Delivery, September 11-14, 2012, Suzhou,China, J. Control. Release 2013, 169, 163-164.   52.pdf

    51. W. Chen, P. Zhong, F.H. Meng*, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Redox and pH-Responsive Degradable Micelles for Dually Activated Intracellular Anticancer Drug Release, J. Control. Release 2013, 169, 171-179. 51.pdf

    50. J. Feijen, W.E. Hennink‌, and Z.Y. Zhong*, Conference Scene: From Innovative Polymers To Advanced Nanomedicine: Key Challenges, Recent Progress and Future Perspectives, Nanomedicine 2013, 8, 177-180. 50.pdf

    49. W. Chen, Y. Zou, J.N. Jia, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Functional Poly(ε-caprolactone)s via Copolymerization of ε‑Caprolactone and Pyridyl Disulfide-Containing Cyclic Carbonate: Controlled Synthesis and Facile Access to Reduction-Sensitive Biodegradable Graft Copolymer Micelles, Macromolecules 2013, 46, 699-707.   49.pdf

  • 2012

    48. F.H. Meng, R. Cheng, C. Deng, and Z.Y. Zhong*, Intracellular Drug Release Nanosystems, Materials Today 2012, 15, 436-442 (invited review)   48.pdf

    47. Y.L. Wu, W. Chen, F.H. Meng, Z.J. Wang, R. Cheng, C. Deng, H.Y. Liu, and Z.Y. Zhong*, Core-Crosslinked pH-Sensitive Degradable Micelles: A Promising Approach to Resolve the Extracellular Stability Versus Intracellular Drug Release Dilemma, J. Control. Release 2012, 164, 338-345.   47.pdf

    46. C. Deng, Y.J. Jiang, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Biodegradable Polymeric Micelles for Targeted and Controlled Anticancer Drug Delivery: Promises, Progress and Prospects, Nano Today 2012, 7, 467-480 (invited review)

    45. R.R. Wei, L. Cheng, M. Zheng, R. Cheng, F.H. Meng, C. Deng, and Z.Y. Zhong*, Reduction-Responsive Disassemblable Core-Cross-Linked Micelles Based on Poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)–Lipoic Acid Conjugates for Triggered Intracelular Anticancer Drug Release, Biomacromolecules 2012, 13, 2429-2438.  45.pdfl

    44. S.K. Li, F.H. Meng, Z.J. Wang, Y.N. Zhong, M. Zheng, H.Y. Liu, and Z.Y. Zhong*, Biodegradable Polymersomes with An Ionizable Membrane: Facile Preparation, Superior Protein Loading, And Endosomal pH-Responsive Protein Release, Eur. J. Pharm. Biopharm. 2012, 82, 103-111 (invited article)  44.pdf

    43. Y.F. Du, W. Chen, M. Zheng, F.H. Meng, and Z.Y. Zhong*, pH-Sensitive Degradable Chimaeric Polymersomes for the Intracellular Release of Doxorubicin Hydrochloride, Biomaterials 2012, 33, 7291-7299.   43.pdf

    42. R. Cheng, X.Y. Wang, W. Chen, F.H. Meng, C. Deng, H.Y. Liu, and Z.Y. Zhong*, Biodegradable Poly(ε-caprolactone)-g-Poly(2-hydroxyethyl methacrylate) Graft Copolymer Micelles as Superior Nano-Carriers for “Smart” Doxorubicin Release, J. Mater. Chem. 2012, 22, 11730-11738.  42.pdf

    41. M. Zheng, Z.H. Zhong, L. Zhou, F.H. Meng, R. Peng, and Z.Y. Zhong*, Poly(ethylene oxide) Grafted with Short Polyethylenimine Gives DNA Polyplexes with Superior Colloidal Stability, Low Cytotoxicity and Potent In Vitro Gene Transfection Under Serum Conditions, Biomacromolecules 2012, 13, 881–888.

    40. W. Wang, H.L. Sun, F.H. Meng, S.B. Ma, H.Y. Liu, and Z.Y. Zhong*, Precise Control of Intracellular Drug Release and Anti-Tumor Activity of Biodegradable Micellar Drugs Via Reduction-Sensitive Shell-Shedding, Soft Matter 2012, 8, 3949-3956.   40.pdf

    39. C.H. Zhu, M. Zheng, F.H. Meng, F.M. Mickler, N. Ruthardt, X.L. Zhu, and Z.Y. Zhong*, Reversibly Shielded DNA Polyplexes Based on Bioreducible PDMAEMA-SS-PEG-SS-PDMAEMA Triblock Copolymers Mediate Markedly Enhanced Nonviral Gene Transfection, Biomacromolecules 2012, 13, 769–778.  39.pdf

    38. J.C. Zhang, L.L. Wu, F.H. Meng, Z.J. Wang, C.Deng, H.Y. Liu, and Z.Y. Zhong*, pH and Reduction Dual-Bioresponsive Polymersomes for Efficient Intracellular Protein Delivery, Langmuir 2012, 28, 2056–2065. (invited article)  38.pdf

    37. M. Zheng, C.M. Yang, F.H. Meng, R. Peng, and Z.Y. Zhong*, pH-Sensitive Degradable Hydrophobe Modified 1.8 kDa Branched Polyethylenimine, as “Artificial Viruses” for Safe and Efficient Intracellular Gene Transfection, Macromol. Res. 2012, 20, 327-334 (Invited Article)  37.pdf

  • 2011

    36. F.X. Zhan, W. Chen, Z.J. Wang, W.T. Lu, R. Cheng, C. Deng, F.H. Meng, H.Y. Liu and Z.Y. Zhong*, Acid-Activatable Prodrug Nanogels for Efficient Intracellular Doxorubicin Release, Biomacromolecules 2011, 12, 3612–3620.  36.pdf

    35. R. Cheng, F.H. Meng, S.B. Ma, H.F. Xu, H.Y. Liu, X.B. Jing, and Z.Y. Zhong*, Reduction and Temperature Dual-Responsive Crosslinked Polymersomes for Targeted Intracellular Protein Delivery, J. Mater. Chem. 2011, 21, 19013-19020.  35.pdf

    34. M. Zheng, Y.N. Zhong, F.H. Meng, R. Peng, and Z.Y. Zhong*, Lipoic Acid Modified Low Molecular Weight Polyethylenimine Mediates Nontoxic and Highly Potent In Vitro Gene Transfection, Mol. Pharmaceutics, 2011, 8, 2434-2443. 34.pdf

    33. Z.Z. Liu, M. Zheng, F.H. Meng, and Z.Y. Zhong*, Non-Viral Gene Transfection In Vitro Using Endosomal pH-Sensitive Reversibly Hydrophobilized Polyethylenimine, Biomaterials 2011, 32, 9109-9119.  33.pdf

    32. R. Wang, W. Chen, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Unprecedented Access to Functional Biodegradable Polymers and Coatings, Macromolecules 2011, 44, 6009–6016.  32.pdf

    31. Y.H. Cong, H. Liu, D.L. Wang, B.J. Zhao, T.Z. Yan, L.B. Li , W. Chen, Z.Y. Zhong , M.-C. Lin, H.-L. Chen, and C.L. Yang, Stretch-Induced Crystallization through Single Molecular Force Generating Mechani**, Macromolecules 2011, 44, 5878-5882.  31.pdf

    30. J. Chen, W. Chen, C. Deng, F.H. Meng, and Z.Y. Zhong*, Controlled Surface-Initiated Ring-Opening Polymerization of L-Lactide from Risedronate-Anchored Hydroxyapatite Nanocrystals: Novel Synthesis of Biodegradable Hydroxyapatite/Poly(L-lactide) Nanocomposites, J. Polym. Sci. Part  A: Polym. Chem. 2011, 49, 4379-4386.   30.pdf

    29. R. Yang, F.H. Meng, S.B. Ma, F.S. Huang, H.Y. Liu, and Z.Y. Zhong*, Galactose-Decorated Crosslinked Biodegradable Poly(Ethylene Glycol)-b-Poly(ε-Caprolactone) Block Copolymer Micelles for Enhanced Hepatoma-Targeting Delivery of Paclitaxel, Biomacromolecules 2011, 12, 3047–3055.  29.pdf

    28. Y.X. Yu, C. Deng, F.H. Meng, Q. Shi, J. Feijen, and Z.Y. Zhong*, Novel Injectable Biodegradable Glycol Chitosan-Based Hydrogels Crosslinked by Michael-Type Addition Reaction with Oligo(acryloyl carbonate)-b-Poly(ethylene glycol)-b-Oligo(acryloyl carbonate) Copolymers, J. Biomed. Mater. Res. Part A  2011, 99A, 316-326. 28.pdf

    27. S.B. Luo, R. Cheng, F.H. Meng, T.G. Park, and Z.Y. Zhong*, Water Soluble Poly(histamine acrylamide) with Superior Buffer Capacity Mediates Efficient and Nontoxic In Vitro Gene Transfection, J. Polym. Sci. Part  A: Polym. Chem. 2011, 49, 3366–3373.   27.pdf

    26. F.H. Meng, and Z.Y. Zhong*, Polymersomes Spanning from Nano to Micro Scales: Advanced Vehicles for Controlled Drug Delivery and Robust Vesicles for Virus and Cell-Mimicking, J. Phys. Chem. Letters 2011, 2, 1533-1539. (Invited Perspective)   26.pdf

    25. H.L. Sun, F.H. Meng, A.A. Dias, M. Hendriks, J. Feijen, and Z.Y. Zhong*, a-Amino Acid Containing Degradable Polymers as Functional Biomaterials: Rational Design, Synthetic Pathway and Biomedical Applications, Biomacromolecules 2011, 12, 1937-1955.   25.pdf

    24. J. Xiong, F.H. Meng, C. Wang, R. Cheng, Z. Liu, and Z.Y. Zhong*, Folate-Conjugated Crosslinked Biodegradable Micelles for Receptor-Mediated Delivery of Paclitaxel, J. Mater. Chem. 2011, 21, 5786-5794.   24.pdf

    23. L. Zhou, R. Cheng, H.Q. Tao, S.B. Ma, W.W. Guo, F.H. Meng, H.Y. Liu, Z. Liu, and Z.Y. Zhong*, Endosomal pH-Activatable Poly(ethylene oxide)-graft-Doxorubicin Prodrugs: Synthesis, Drug Release, and Biodistribution in Tumor-Bearing Mice, Biomacromolecules 2011, 12, 1460–1467.  23.pdf

    22. Y.H. Wang, M. Zheng, F.H. Meng, J. Zhang, R. Peng, and Z.Y. Zhong*, Branched Polyethylenimine Derivatives with Reductively Cleavable Periphery for Safe and Efficient In Vitro Gene Transfer, Biomacromolecules 2011, 12, 1032-1040.  22.pdf

    21. R. Cheng, F. Feng, F.H. Meng, C. Deng, J. Feijen, Z.Y. Zhong*, Glutathione-Responsive Nano-Vehicles as a Promising Platform for Targeted Intracellular Drug and Gene Delivery, J. Control. Release 2011, 152, 2-12. 21.pdf

    20. Z.Y. Zhong*, and J. Feijen, The First Symposium on Innovative Polymers for Controlled Delivery, September 14-17, 2010, Suzhou, China, J. Control. Release 2011, 152, 1-1. 20.pdf

  • 2010

    19. G.J. Liu, S.B. Ma, S.K. Li, R. Cheng, F.H. Meng,*, H.Y. Liu, Z.Y. Zhong*, The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes, Biomaterials 2010, 31, 7575-7585. 19.pdf

    18. R. Jin, L.S. MoreiraTeixeira,  P.J. Dijkstra, Z.Y. Zhong, C.A. van Blitterswijk, M. Karperien, J. Feijen, Enzymatically crosslinked dextran-tyramine hydrogels as injectable scaffolds for cartilage tissue engineering, Tissue Engineering Part A. 2010,16, 2429-2440. 

    17. C.H. Zhu, S.Y. Jung, G.Y. Si, R. Cheng, F.H. Meng*, X.L. Zhu, T.G. Park, and Z.Y. Zhong*, Cationic methacrylate copolymers containing primary and tertiary amino side groups: controlled synthesis via RAFT polymerization, DNA condensation, and in vitro gene transfection, J. Polym. Sci. Part  A: Polym. Chem.  2010, 48, 2869–2877. 17.pdf  

    16. H.L. Sun, F.H. Meng*, B.N. Guo, X.Q. Li, R. Cheng, H.Y. Liu, and Z.Y. Zhong*, Shell-sheddable micelles based on dextran-ss-poly(e-caprolactone) diblock copolymer for efficient intracellular release of doxorubicin, Biomacromolecules 2010, 11, 848–854.  16.pdf

    15. R. Namgung, J.H. Brumbach, J.H. Jeong, J.W. Yockman, S.W. Kim, C. Lin, Z.Y. Zhong, J. Feijen, J.F.J. Engbersen, and W.J. Kim*,  Dual bio-responsive gene delivery via reducible poly(amido amine) and survivin-inducible pla**id DNA, Biotechnol. Lett. 2010, 32, 755-764.  15.pdf

    14. C.H. Zhu, S.Y. Jung, S.B. Luo, F.H. Meng, X.L. Zhu, T.G. Park, and Z.Y. Zhong*, Co-delivery of siRNA and Paclitaxel into Cancer Cells by Biodegradable Cationic Micelles Based on PDMAEMA-PCL-PDMAEMA Triblock Copolymers, Biomaterials 2010, 31, 2408–2416. 14.pdf

    13. W. Chen, F.H. Meng*, R. Cheng, and Z.Y. Zhong*, pH-Sensitive Degradable Polymersomes for Triggered Release of Anticancer Drugs: a Comparative Study with Micelles, J. Control. Release 2010, 142, 40-46.  13.pdf

    12. W. Chen, H.C. Yang, R. Wang, R. Cheng, F.H. Meng*, W.X. Wei, and Z.Y. Zhong*, Versatile Synthesis of Functional Biodegradable Polymers by Combining Ring-Opening Polymerization and Postpolymerization Modification via Michael-Type Addition Reaction, Macromolecules 2010, 43, 201–207.  12.pdf

    11. J.M. Jukes, L.J. van der Aa, C. Hiemstra, T. van Veen, P.J. Dijkstra, Z.Y. Zhong, J. Feijen, C.A. van Blitterswijk, J. de Boer, A newly developed chemically crosslinked Dex-PEG hydrogel for cartilage tissue engineering, Tissue Engineering Part A. 2010, 16: 565-573.  11.pdf

  • 2009

    10. Y.L. Li, L. Zhu, Z.Z. Liu, R. Cheng, F.H. Meng*, J.H. Cui, S.J. Ji, and Z.Y. Zhong*, Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells, Angew. Chem. Int. Ed. 2009, 48, 9914-9918. 10.pdf

    9. Y.M. Xu, F.H. Meng*, R. Cheng, Z.Y. Zhong*, Reduction-Sensitive Reversibly Crosslinked Biodegradable Micelles for Triggered Release of Doxorubicin, Macromol. Biosci. 2009, 9, 1254-1261. 9.pdf

    8. H.Z. Du, A.H. Velders, P.J. Dijkstra, Z.Y. Zhong, X.S. Chen, J. Feijen, Chiral Salan Aluminum Ethyl Complexes and Their Application in Lactide Polymerization, Chem.-Eur. J. 2009, 15: 9836-9845. 8.pdf

    7. H.L. Sun, B.N. Guo, R. Cheng, F.H. Meng *, H.Y. Liu, Z.Y. Zhong*, Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin, Biomaterials  2009, 30: 6358-6366. 7.pdf

    6. W. Chen, F.H. Meng, F. Li, S.-J. Ji, Z.Y. Zhong*, pH-Responsive Biodegradable Micelles Based on Acid-Labile Polycarbonate Hydrophobe: Synthesis and Triggered Drug Release, Biomacromolecules 2009, 10: 1727-1735. 6.pdf

    5. H.F. Xu, F.H. Meng*, Z.Y. Zhong*, Reversibly crosslinked temperature-responsive nano-sized polymersomes: synthesis and triggered drug release, J. Mater. Chem. 2009, 19: 4183-4190.  5.pdf

    4. F.H. Meng, W.E.Hennink,  Z.Y. Zhong*, Reduction-Sensitive Polymers and Bioconjugates for Biomedical Applications, Biomaterials  2009, 30:2180-2198.   4.pdf

    3. R. Jin, L.S. Moreira Teixeira, P.J. Dijkstra, M. Karperien, Z.Y. Zhong, J. Feijen, Injectable Chitosan-based Hydrogels for Cartilage Tissue Engineering, Biomaterials 2009, 30:2544-2551 3.pdf

    2. H.Z. Du, A.H. Velders, P.J. Dijkstra, Z.Y. Zhong, X.S. Chen, J. Feijen, Polymerization of lactide using achiral bis(pyrrolidene) schiff base aluminum complexes, Macromolecules 2009, 42: 1058–1066.  2.pdf

    1. F.H. Meng, Z.Y. Zhong*, J. Feijen, Stimuli-responsive polymersomes for programmed drug delivery. Biomacromolecules 2009, 10: 197-209.  1.pdf