Dr. Wenhai Lin is an associate research fellow at College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China. He received his B. Eng and Ph.D degrees (Supervisor: Prof. Zhigang Xie) from Jilin University in 2013 and University of Chinese Academy of Sciences in 2019, respectively. He worked as a Postdoc in University of Massachusetts Medical School (Co-advisor: Prof. Gang Han) for 2 years and then City University of Hong Kong (Co-advisor: Prof. Stella W. Pang) for 1 year. In Nov. 2022, He joined the Biomedical Polymers Laboratory at Soochow University. He has published over 30 SCI papers. His current research interest is design and synthesis of multifunctional photosensitizers and polymeric nanoparticles for tumor theranositics.
1. Quan, L.; Moreno-Gonzalez, I.; Xie, Z.; Gamez, N.; Vegas-Gomez, L.; Song, Q.; Gu, J.; Lin, W.; Gomez-Gutierrez, R.; Wu, T. A near-infrared probe for detecting and interposing amyloid beta oligomerization in early Alzheimer's disease. Alzheimer's & Dementia2022, 1-11.
2. Zeng, L.; Huang, L.; Wang, Z.; Wei, J.; Huang, K.; Lin, W.; Duan, C.; Han, G. Self-Assembled Metal–Organic Framework Stabilized Organic Cocrystals for Biological Phototherapy. Angewandte Chemie International Edition2021, 60, 23569-23573.
3. Li, C.; Lin, W.; Liu, S.; Sun, T.; Xie, Z. Structural optimization of organic fluorophores for highly efficient photothermal therapy. Materials Chemistry Frontiers2021, 5, 284-292.
4. Lin, W.; Colombani-Garay, D.; Huang, L.; Duan, C.; Han, G. Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy. WIREs Nanomedicine and Nanobiotechnology2020, e1627.
5. Huang, L.; Wu, W.; Li, Y.; Huang, K.; Zeng, L.; Lin, W.; Han, G. Highly Effective Near-Infrared Activating Triplet–Triplet Annihilation Upconversion for Photoredox Catalysis. Journal of the American Chemical Society 2020, 142, 18460-18470.
6. Zhou, Y.; Zhang, Y.; Lin, W.; Kesseli, S. J.; Huang, L.; Zhao, Y.; Yao, X.; Huang, K.; Han, G. Wavelength‐Selective Light‐Controlled Stepwise Photolysis from Single Gold Nanoparticles. Advanced Healthcare Materials2020, 2000321.
7. Lin, W.; Zhang, W.; Liu, S.; Li, Z.; Hu, X.; Xie, Z.; Duan, C.; Han, G. Engineering pH-Responsive BODIPY Nanoparticles for Tumor Selective Multimodal Imaging and Phototherapy. ACS Applied Materials & Interfaces2019, 11, 43928-43935.
8. Wang, X.; Lin, W.*; Zhang, W.; Li, C.; Sun, T.; Chen, G.; Xie, Z. Amphiphilic redox-sensitive NIR BODIPY nanoparticles for dual-mode imaging and photothermal therapy. Journal of Colloid and Interface Science 2019, 536, 208-214.
9. Zhang, W.; Lin, W.; Li, C.; Liu, S.; Hu, X.; Xie, Z. Rational Design of BODIPY-Diketopyrrolopyrrole Conjugated Polymers for Photothermal Tumor Ablation. ACS Applied Materials & Interfaces2019, 11, 32720-32728.
10. Li, C.; Lin, W.; Liu, S.; Zhang, W.; Xie, Z. Self-destructive PEG-BODIPY nanomaterials for photodynamic and photothermal therapy. Journal of Materials Chemistry B 2019, 7, 4655-4660.
11. Quan, L.; Gu, J.; Lin, W.; Wei, Y.; Lin, Y.; Liu, L.; Ding, H.; Pan, C.; Xie, Z.; Wu, T. A BODIPY biosensor to detect and drive self-assembly of diphenylalanine. Chemical Communications 2019, 55, 8564-8566.
12. Wang, X.; Fu, L.; Lin, W.; Zhang, W.; Pei, Q.; Zheng, X.; Liu, S.; Zhang, T.; Xie, Z. Vaginal delivery of mucus-penetrating organic nanoparticles for photothermal therapy against cervical intraepithelial neoplasia in mice. Journal of Materials Chemistry B 2019, 7, 4528-4537.
13. Lin, W.; Yin, L.; Sun, T.; Wang, T.; Xie, Z.; Gu, J.; Jing, X. The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines. Biomacromolecules 2018, 19, 1625-1634.
14. Zhu, Y.; Lin, W.*; Wang, X.; Zhang, W.; Chen, L.; Xie, Z. Constructing reduction-sensitive PEGylated NIRF mesoporous silica nanoparticles via a one-pot Passerini reaction for photothermal/chemo-therapy. Chemical Communications2018, 54, 11921-11924.
15. Zhang, W.; Lin, W.; Wang, X.; Li, C.; Liu, S.; Xie, Z. Hybrid Nanomaterials of Conjugated Polymers and Albumin for Precise Photothermal Therapy. ACS Applied Materials & Interfaces 2018, 11, 278-287.
16. Zong, S.; Wang, X.; Lin, W.; Liu, S.; Zhang, W. Simple D-A-D Structural Bisbithiophenyl Diketopyrrolopyrrole (TDPP) as Efficient Bioimaging and Photothermal Agents. Bioconjugate Chemistry2018, 29, 2619-2627.
17. Lin, W.; Zhang, W.; Sun, T.; Liu, S.; Zhu, Y.; Xie, Z. Rational Design of Polymeric Nanoparticles with Tailorable Biomedical Functions for Cancer Therapy. ACS Applied Materials & Interfaces 2017, 9, 29612-29622.
18. Zhu, Y.; Lin, W.*; Zhang, W.; Feng, Y.; Wu, Z.; Chen, L.; Xie, Z. PEGylated BODIPY Assembling Fluorescent Nanoparticles for Photodynamic Therapy. Chinese Chemical Letters 2017, 28, 1875-1877.
19. Lin, W.; Xie, Z.; Jing, X. Self-Assembling Organic Nanoparticles for Bioimaging and Cargo Delivery. Journal of Controlled Release 2017, 259, e140-e141.
20. Zhang, W.; Lin, W.; Zheng, X.; He, S.; Xie, Z. Comparing Effects of Redox Sensitivity of Organic Nanoparticles to Photodynamic Activity. Chemistry of Materials 2017, 29, 1856-1863.
21. Lin, W.; Zhang, W.; Sun, T.; Gu, J.; Xie, Z.; Jing, X. Effect of Molecular Structure on Stability of Organic Nanoparticles Formed by Bodipy Dimers. Langmuir 2016, 32, 9575-9581.
22. Lin, W.; Li, Y.; Zhang, W.; Liu, S.; Xie, Z.; Jing, X. Near-Infrared Polymeric Nanoparticles with High Content of Cyanine for Bimodal Imaging and Photothermal Therapy. ACS Applied Materials & Interfaces 2016, 8, 24426-24432.
23. Lin, W.; Sun, T.; Xie, Z.; Gu, J.; Jing, X. A Dual-Responsive Nanocapsule via Disulfide-Induced Self-Assembly for Therapeutic Agent Delivery. Chemical Science 2016, 7, 1846-1852.
24. Sun, T.; Lin, W; Zhang, W.; Xie, Z. Self‐Assembly of Amphiphilic Drug–Dye Conjugates into Nanoparticles for Imaging and Chemotherapy. Chemistry – An Asian Journal2016, 11, 3174-3177.
25. Zhang, W.; Lin, W.; Pei, Q.; Hu, X.; Xie, Z.; Jing, X. Redox-Hypersensitive Organic Nanoparticles for Selective Treatment of Cancer Cells. Chemistry of Materials 2016, 28, 4440-4446.
26. Lin, W.; Guan, X.; Sun, T.; Huang, Y.; Jing, X.; Xie, Z. Reduction-Sensitive Amphiphilic Copolymers Made via Multi-Component Passerini Reaction for Drug Delivery. Colloids and Surfaces B: Biointerfaces 2015, 126, 217-223.
27. Lin, W.; Sun, T.; Zheng, M.; Xie, Z.; Huang, Y.; Jing, X. Synthesis of Cross-Linked Polymers via Multi-Component Passerini Reaction and Their Application as Efficient Photocatalysts. RSC Advances 2014, 4, 25114.
28. Zong, S.; Wang, X.; Yang, Y.; Wu, W.; Li, H.; Ma, Y.; Lin, W.; Sun, T.; Huang, Y.; Xie, Z.; Yue, Y.; Liu, S.; Jing, X. The Use of Cisplatin-Loaded Mucoadhesive Nanofibers for Local Chemotherapy of Cervical Cancers in Mice. European Journal of Pharmaceutics and Biopharmaceutics 2015, 93, 127-135.
29. Quan, L.; Liu, S.; Sun, T.; Guan, X.; Lin, W.; Xie, Z.; Huang, Y.; Wang, Y.; Jing, X. Near-Infrared Emitting Fluorescent BODIPY Nanovesicles for in Vivo Molecular Imaging and Drug Delivery. ACS Applied Materials & Interfaces 2014, 6, 16166-16173.
30. Quan, L.; Sun, T.; Lin, W.; Guan, X.; Zheng, M.; Xie, Z.; Jing, X. BODIPY Fluorescent Chemosensor for Cu2+ Detection and Its Applications in Living Cells: Fast Response and High Sensitivity. Journal of Fluorescence 2014, 24, 841-846.
31. Quan, L.; Lin, W.; Sun, T.; Xie, Z.; Huang, Y.; Jing, X. Green Photocatalysis with Oxygen Sensitive BODIPYs under Visible Light. Catalysis Letters 2014, 144, 308-313.
32. Hu, X.; Li, J.; Lin, W.; Huang, Y.; Jing, X.; Xie, Z. Paclitaxel Prodrug Nanoparticles Combining Chemical Conjugation and Physical Entrapment for Enhanced Antitumor Efficacy. RSC Advances 2014, 4, 38405-38411.