Dr.WeijingYangis a Distinguished Professor and Ph.D. Supervisor at Soochow University. She received her B.S. in Materials Chemistry from the School of Materials Science and Engineering, Zhengzhou University, in July 2012.Her Ph.D.wasin Polymer Chemistry and Physics from theCollege of Chemistry, Chemical Engineering and Materials Science, Soochow University, in June 2017. She then conducted postdoctoral research for several years at the National Institutes of Health (NIH), USA. From January 2021 to January 2026, she served as a Distinguished Professor at Zhengzhou University, and in February 2026, she was appointed Distinguished Professor at Soochow University.Asthefirst or corresponding author, she has published more than 20 papers in leading journals, includingNat. Commun.,Sci. Adv., andAdv. Mater., with 2 ESI Highly Cited Papers and 1 cover article. Her publications have receivedover4600 citations on Google Scholar, with an H-index of 37. She holds 8 authorized invention patents and has successfully completedone projectfunded by the National Natural Science Foundation of China (NSFC).
She serves asanAssociate Editor of Frontiers in Nanotechnology and as a Young Editorial Board Member ofMater. Today Bio,Chin. Chem. Lett.,Nano TransMed, andOncol. Transl. Med.. She is also an independent reviewer for journals such asAdv. Mater.,Cell Rep. Med.,ACS Nano,Mater. Today,Adv. Funct. Mater., andAdv. Sci.. She has received several honors, including Henan High-Level Talent (Category C), Henan Distinguished Professor, and Zhongyuan Talent Program awardee.
Her research focuses on the synthesis of immunoregulatory polymeric biomaterials for drug delivery and cancer immunotherapy.
Representative papers:
1.Li Y. J., Dong Y., Shen D. Y., Guo Y. C., Cao Y. J., Zhang K. X., Li X. Y., Zhu R. R., Yi J. M., Yao X. H., Zhang Z. Z.*, Qin Z. H.*,Yang W. J.* Personalized Nanovaccine Based on STING-Activating Nanocarrier for Robust Cancer Immunotherapy.ACS Nano2025, 19, 3226-3239.
2.Yang W. J., Zhang K. X., Guo Y. C., Weng X., Wang Y. Y., Wang X. X., Zhao G. D., Li Y. J.*, Wang L.* A bispecific nanoregulator for T cell targeting-mediated sequential immunotherapy with spatiotemporal orchestration of tumor microenvironment.Chem. Eng. J.2025, 36, 110704.
3.Li Y. J., Zhu R. R., Guo Y. C., Wang Y. Y., Ma R., Ma K. R., Zhao Y. X.*,Yang W. J.* Sequential-gated transformable nanoprodrug potentiates antitumor immunity through TME modulation and STING activation.Chin. Chem. Lett.2025, 36, 110704.
4.Li Y. J., Zhu X. R., Wang X. X., Zhao G. D., Hu M. Y., Guo Y. C.,Yang W.J.* Nanoengineered Bispecific Antibodies Mediate Cell to Cell Movement for Boosting Cancer Immunotherapy.ACS Nano Med.2025,https://doi.org/10.1021/acsnanomed.5c00094.
5.Guo Y. C.#, Li Y. J.#, Zhang M. Z., Ma R., Wang Y. Y., Weng X., Zhang J. J., Zhang Z. Z.*, Chen X. Y.*,Yang W. J.* Polymeric Nanocarrier via Metabolism Regulation Mediates Immunogenic Cell Death with Spatiotemporal Orchestration for Cancer Immunotherapy.Nat. Commun.2024, 15, 8586.
6.Li Y. J.#, Li X. Y.#, Zhang M. Z., Weng X., Yi J. M., Cao Y. J., Lei N. J., Qin Z. H.*, Chen X. Y.*,Yang, W. J.* Spatiotemporal orchestration of a ferroptosis-immunotherapy “cycle”via a sequential drug delivery system for antitumor immunity.Nano Today2024, 59, 102535.
7.Li Y. J.#, Guo Y. C.#, Zhang K. X., Zhu R. R., Chen X. Y.*, Zhang Z. Z.*,Yang W. J.* Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity.Adv. Sci.2024, 11, 2306580.
8.Li Y. J., Yi J. M., Ma R., Wang Y. Y., Lou X. H., Dong Y., Cao Y. J., Li X. Y., Wang M., Dang X. W., Li R., Lei N. J., Song H. W.*, Qin Z. H.*,Yang W. J.* A polymeric nanoplatform enhances the cGAS-STING pathway in macrophages to potentiate phagocytosis for cancer immunotherapy. J. Control. Release2024, 373, 447-662.
9.Li Y. J.#, Cao Y. J.#, Ma K. R., Ma R., Zhang M. Z., Guo Y. C., Song H. W., Sun N. N.*, Zhang Z. Z.*,Yang W. J.* A Triple-Responsive Polymeric Prodrug Nanoplatform with Extracellular ROS Consumption and Intracellular H2O2 Self-Generation for Imaging-Guided Tumor Chemo-Ferroptosis-Immunotherapy.Adv. Healthc. Mater.2024, 13, 2303568.
10.Wei Y. H., Weng X., Wang Y. Y.,Yang W. J.* Stimuli-Responsive Polymersomes: Reshaping the Immunosuppressive Tumor Microenvironment.Biomacromolecules2024, 25, 4663-4676.
11.Yang W. J., Yi J. M., Zhu R. R., Guo Y. C., Zhang K. X., Cao Y. J., Li X. Y., Zhang J. J., Zhang Z. Z., Li Y. J.*, Chen X. Y.* Transformable prodrug nanoplatform via tumor microenvironment modulation and immune checkpoint blockade potentiates immunogenic cell death mediated cancer immunotherapy.Theranostics2023, 13, 1906-1920.
12.Li Y. J., Li X. Y., Yi J. M., Cao Y. J., Qin Z. H.*, Zhong Z. Y.*, Yang W. J.* Nanoparticle-Mediated STING Activation for Cancer Immunotherapy.Adv. Healthc. Mater. 2023, 12, 2300260.
13.Hou L.*, Gong X., Yang J., Zhang H. J.,Yang W. J.*, Chen X. Y.* Hybrid Membrane-Decorated Prussian Blue for Effective Cancer Immunotherapy via Tumor-Associated Macrophages Polarization and Hypoxia Relief. Adv. Mater. 2022, 34, 2200389.
14.Yang W. J.*, Zhang M., Zhang J. J., Liu Y. L., Ning J., Yang J., Zhang Z. Z., Hou L.*, Chen X. Y.*, In vivo activated T cell targeting with PD-1/PD-L1 blockade for sequential treatment mediated cancer immunotherapy. Nano Today 2022, 44, 101492.
15.Yang W. J., Deng H. Z., Zhu S. J., Lau J., Tian R., Wang S., Zhou Z. J., Yu G. C., Rao L., He L. C., Ma Y., Chen X. Y.* Size-Transformable Antigen-Presenting Cell Mimicking Nanovesicles Potentiate Effective Cancer Immunotherapy.Sci. Adv.2020, 6, eabd1631.
16.Yang W. J.,# Zhang F. W.,# Deng H. Z., Lin L. S., Wang S., Kang F., Yu G. C., Lau J., Tian R., Zhang M. R., Wang Z. T., He L. C., Ma Y., Niu G., Hu S.*, Chen X. Y.* Smart Nanovesicle Mediated Immunogenic Cell Death through Tumor Microenvironment Modulation for Effective Photodynamic Immunotherapy.ACS Nano2020, 14, 620-631.
17.Yang W. J., Zhu G. Z., Wang S., Yu G. C., Yang Z., Lin L. S., Zhou Z. J., Liu Y. J., Dai Y. L., Zhang F. W., Shen Z. Y., Liu Y., He Z. M., Lau J., Niu G., Kiesewetter D. O., Hu S.*, Chen X. Y.*In situ dendritic cell vaccine for effective cancer immunotherapy.ACS Nano2019, 13, 3083-3094.
18.Yang W. J., Zhou Z. J., Lau J., Hu S.*, Chen X. Y.* Functional T cell activation by smart nanosystems for effective cancer immunotherapy.Nano Today2019, 27, 28-47.
19.Xu X.#,Yang W. J.#, Liang Q. J., Shi Y. N., Zhang W. X., Wang X., Meng F. H., Zhong Z. Y.*, Yin L. C.* Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC). Nano Res. 2019, 12, 659-667.
20.Yang W. J.#, Wei Y. H.#, Yang L., Zhang J., Zhong Z. Y.*, Storm G., Meng F. H.* Granzyme B-loaded, cell-selective penetrating and reduction-responsive polymersomes effectively inhibit progression of orthotopic human lung tumor in vivo.J. Control. Release2018, 290, 141-149.
21.Yang W. J., Yang L., Xia Y. F., Cheng L.*, Zhang J., Meng F. H.*, Yuan J. D., Zhong Z. Y.* Lung cancer specific and reduction-responsive chimaeric polymersomes for highly efficient loading of pemetrexed and targeted suppression of lung tumor in vivo. Acta Biomater. 2018, 70, 177-185.
22.Yang W. J., Xia Y. F., Fang Y., Meng F. H.*, Zhang J., Cheng R., Deng C., Zhong Z. Y.* Selective cell penetrating peptide-functionalized polymersomes mediate efficient and targeted delivery of methotrexate disodium to human lung cancer in vivo.Adv. Healthc. Mater.2018, 7, 1701135.
23.Yang W. J., Xia Y. F., Zou Y., Meng F. H.*, Zhong Z. Y.* Bioresponsive chimaeric nano-polymersomes enable targeted and efficacious protein therapy for human lung cancersin vivo.Chem. Mater.2017, 29, 8757-8765.
24.Yang W. J., Zou Y., Meng F. H.*, Zhang J., Cheng R., Deng C., Zhong Z. Y.* Efficient and targeted suppression of human lung tumor xenografts in mice with methotrexate sodium encapsulated in all-function-in-one chimeric polymersomes.Adv. Mater.2016, 28, 8234-8239.