Dr. Huanli Sun is an associate professor at College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou,China. She obtained her B.S. and Ph.D degrees from Soochow University in 2008 and 2013, respectively, under the supervision of Prof. Zhiyuan Zhong. Afterwards, she worked as a postdoctoral research fellow with Prof. Frank Caruso at The University of Melbourne, Australia. She then joined the Biomedical Polymers Laboratory at Soochow University in Sep. 2015. She has published over 40 peer-reviewed papers with a total citation of >1,700. Her current research interests are developing multifunctional polymeric nanomedicines, and exploring monoclonal antibody and polysaccharide mediated active tumor chemotherapy.
Representative Papers
[1] S. Yue, J. An, Y. Zhang, J. Li, C. Zhao, J. Liu, L. Liang, H. Sun*, Y. Xu*, Z. Zhong*, Exogenous antigen upregulation empowers antibody targeted nanochemotherapy of leukemia. Advanced Materials2023, 35, 2209984.
[2] J. Du, S. Yue, C. Li, J. Li, S. Zhao, Y. Dong, Y. Zhang, R. Cheng, H. Sun*, Z. Zhong*, Exogenous CD38 upregulation enables high-efficacy dually cascade targeted molecular therapy of leukemia. Nano Today2023, 50, 101872.
[3] J. Liu, L. Zhang, D. Zhao, S. Yue, H. Sun*, C. Ni, Z. Zhong*, Polymersome-stabilized doxorubicin-lipiodol emulsions for high-efficacy chemoembolization therapy. Journal of Controlled Release2022, 350, 122-131.
[4] Y. Zhang, J. An, Y. Shao, N. Yu, S. Yue, H. Sun*, J. Zhang, W. Gu, Y. Xia, J. Zhang, Y. Xu*, Z. Zhong*, CD38-directed vincristine nanotherapy for acute lymphoblastic leukemia. Biomacromolecules2022, 23, 377-387.
[5] S. Yue, Y. Zhang, Y. Wei, R. Haag, H. Sun*, Z. Zhong*, Cetuximab–polymersome–mertansine nanodrug for potent and targeted therapy of EGFR-positive cancers. Biomacromolecules2022, 23, 100-111.
[6] N. Yu, Y. Zhang, J. Li, W. Gu, S. Yue, B. Li, F. Meng, H. Sun*, R. Haag, J. Yuan, Z. Zhong*, Daratumumab immunopolymersome-enabled safe and CD38-targeted chemotherapy and depletion of multiple myeloma. Advanced Materials2021, 33, 2007787.
[7] Y. Zhang, S. Yue, R. Haag, H. Sun*, Z. Zhong*, An intelligent cell-selective polymersome-DM1 nanotoxin toward triple negative breast cancer. Journal of Controlled Release2021, 340, 331-341.
[8] H. Sun, Z. Zhong*, 100th anniversary of macromolecular science viewpoint: Biological stimuli-sensitive polymer prodrugs and nanoparticles for tumor-specific drug delivery. ACS Macro Letter2020, 9, 1292-1302.
[9] H. Sun, Z. Zhong*, J. Feijen*, The fifth symposium on innovative polymers for controlled delivery (sipcd 2018), september 14-17, 2018, suzhou, china. Journal of Controlled Release2019, 307, 410-412.
[10] Y. Yan, Y. Dong, S. Yue, X. Qiu, H. Sun*, Z. Zhong*, Dually active targeting nanomedicines based on a direct conjugate of two purely natural ligands for potent chemotherapy of ovarian tumors. ACS Applied Materials & Interfaces2019, 11, 46548-46557.
[11] P. Yao, Y. Zhang, H. Meng, H. Sun*, Z. Zhong*, Smart polymersomes dually functionalized with cRGD and fusogenic gala peptides enable specific and high-efficiency cytosolic delivery of apoptotic proteins. Biomacromolecules2019, 20, 184-191.
[12] L. Ding, W. Gu, Y. Zhang, S. Yue, H. Sun*, J.J.L.M. Cornelissen, Z. Zhong*, HER2-specific reduction-sensitive immunopolymersomes with high loading of epirubicin for targeted treatment of ovarian tumor. Biomacromolecules2019, 20, 3855-3863.
[13] H. Sun, X. Gu, Q. Zhang, H. Xu, Z. Zhong*, C. Deng*, Cancer nanomedicines based on synthetic polypeptides. Biomacromolecules2019, 20, 4299-4311.
[14] H. Sun, Z. Zhong*, Biomacromolecules for emerging biological and medical science and technology. Biomacromolecules2019, 20, 4241-4242.
[15] H. Sun, Y. Zhang, Z. Zhong*, Reduction-sensitive polymeric nanomedicines: An emerging multifunctional platform for targeted cancer therapy. Advanced Drug Delivery Reviews2018, 132, 16-32.
[16] H. Sun, Y. Dong, F. Jan*, Z. Zhong*, Peptide-decorated polymeric nanomedicines for precision cancer therapy. Journal of Controlled Release2018, 290, 11-27.
[17] H. Sun, H.-A. Klok*, Z. Zhong*, Polymers from nature and for nature. Biomacromolecules2018, 19, 1697-1700.
[18] Y. Zhang, K. Wu, H. Sun*, J. Zhang, J. Yuan, Z. Zhong*, Hyaluronic acid-shelled disulfide-cross-linked nanopolymersomes for ultrahigh-efficiency reactive encapsulation and CD44-targeted delivery of mertansine toxin. ACS Applied Materials & Interfaces2018, 10, 1597-1604.
