杨炜静，苏州大学特聘教授，博士生导师。2012年7月于郑州大学材料科学与工程学院获材料化学专业学士学位，2017年6月于苏州大学材料与化学化工学部获高分子化学与物理专业博士学位，随后在美国国立卫生研究院（NIH）从事博士后研究多年。2021年1月至2026年1月归国任郑州大学特聘教授，2026年2月受聘为苏州大学材料与化学化工学部特聘教授。以第一/通讯作者在Nat. Commun.、Sci. Adv.、Adv. Mater.等杂志发表论文二十余篇，ESI高被引论文2篇，封面论文1篇，谷歌学术引用4600余次，H指数37；授权发明专利8项；已顺利完成国家自然科学基金青年项目。担任Frontiers in Nanotechnology副主编，Materials Today Bio、Chinese Chemical Letters、Nano TransMed、Oncology Translational Medicine等杂志青年编委；担任Adv. Mater.、Cell Rep. Med.、ACS Nano、Mater. Today、Adv. Funct. Mater.、Adv. Sci.等杂志独立审稿人。获河南省高层次人才C类、河南省特聘教授、中原英才项目获得者等荣誉称号。
主要研究方向为免疫调节型医用高分子材料合成用于药物递送及肿瘤免疫治疗。
代表性论文（Representative papers）：
1. Li Y. J., Dong Y., Shen D. Y., Guo Y. C., Cao Y. J., Zhang K. X., Li X. Y., Zhu R. R., Yi J. M., Yao X. H., Zhang Z. Z.*, Qin Z. H.*,Yang W. J.* Personalized Nanovaccine Based on STING-Activating Nanocarrier for Robust Cancer Immunotherapy.ACS Nano2025, 19, 3226-3239.
2. Yang W. J., Zhang K. X., Guo Y. C., Weng X., Wang Y. Y., Wang X. X., Zhao G. D., Li Y. J.*, Wang L.* A bispecific nanoregulator for T cell targeting-mediated sequential immunotherapy with spatiotemporal orchestration of tumor microenvironment.Chem. Eng. J.2025, 36, 110704.
3. Li Y. J., Zhu R. R., Guo Y. C., Wang Y. Y., Ma R., Ma K. R., Zhao Y. X.*,Yang W. J.* Sequential-gated transformable nanoprodrug potentiates antitumor immunity through TME modulation and STING activation.Chin. Chem. Lett.2025, 36, 110704.
4. Li Y. J., Zhu X. R., Wang X. X., Zhao G. D., Hu M. Y., Guo Y. C.,Yang W.J.* Nanoengineered Bispecific Antibodies Mediate Cell to Cell Movement for Boosting Cancer Immunotherapy.ACS Nano Med.2025,https://doi.org/10.1021/acsnanomed.5c00094.
5. Guo Y. C.#, Li Y. J.#, Zhang M. Z., Ma R., Wang Y. Y., Weng X., Zhang J. J., Zhang Z. Z.*, Chen X. Y.*,Yang W. J.* Polymeric Nanocarrier via Metabolism Regulation Mediates Immunogenic Cell Death with Spatiotemporal Orchestration for Cancer Immunotherapy.Nat. Commun.2024, 15, 8586.
6. Li Y. J.#, Li X. Y.#, Zhang M. Z., Weng X., Yi J. M., Cao Y. J., Lei N. J., Qin Z. H.*, Chen X. Y.*,Yang, W. J.* Spatiotemporal orchestration of a ferroptosis-immunotherapy “cycle”via a sequential drug delivery system for antitumor immunity.Nano Today2024, 59, 102535.
7. Li Y. J.#, Guo Y. C.#, Zhang K. X., Zhu R. R., Chen X. Y.*, Zhang Z. Z.*,Yang W. J.* Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity.Adv. Sci.2024, 11, 2306580.
8. Li Y. J., Yi J. M., Ma R., Wang Y. Y., Lou X. H., Dong Y., Cao Y. J., Li X. Y., Wang M., Dang X. W., Li R., Lei N. J., Song H. W.*, Qin Z. H.*,Yang W. J.* A polymeric nanoplatform enhances the cGAS-STING pathway in macrophages to potentiate phagocytosis for cancer immunotherapy. J. Control. Release2024, 373, 447-662.
9. Li Y. J.#, Cao Y. J.#, Ma K. R., Ma R., Zhang M. Z., Guo Y. C., Song H. W., Sun N. N.*, Zhang Z. Z.*,Yang W. J.* A Triple-Responsive Polymeric Prodrug Nanoplatform with Extracellular ROS Consumption and Intracellular H2O2 Self-Generation for Imaging-Guided Tumor Chemo-Ferroptosis-Immunotherapy.Adv. Healthc. Mater.2024, 13, 2303568.
10. Wei Y. H., Weng X., Wang Y. Y.,Yang W. J.* Stimuli-Responsive Polymersomes: Reshaping the Immunosuppressive Tumor Microenvironment.Biomacromolecules2024, 25, 4663-4676.
11. Yang W. J., Yi J. M., Zhu R. R., Guo Y. C., Zhang K. X., Cao Y. J., Li X. Y., Zhang J. J., Zhang Z. Z., Li Y. J.*, Chen X. Y.* Transformable prodrug nanoplatform via tumor microenvironment modulation and immune checkpoint blockade potentiates immunogenic cell death mediated cancer immunotherapy.Theranostics2023, 13, 1906-1920.
12. Li Y. J., Li X. Y., Yi J. M., Cao Y. J., Qin Z. H.*, Zhong Z. Y.*, Yang W. J.* Nanoparticle-Mediated STING Activation for Cancer Immunotherapy.Adv. Healthc. Mater. 2023, 12, 2300260.
13. Hou L.*, Gong X., Yang J., Zhang H. J.,Yang W. J.*, Chen X. Y.* Hybrid Membrane-Decorated Prussian Blue for Effective Cancer Immunotherapy via Tumor-Associated Macrophages Polarization and Hypoxia Relief. Adv. Mater. 2022, 34, 2200389.
14. Yang W. J.*, Zhang M., Zhang J. J., Liu Y. L., Ning J., Yang J., Zhang Z. Z., Hou L.*, Chen X. Y.*, In vivo activated T cell targeting with PD-1/PD-L1 blockade for sequential treatment mediated cancer immunotherapy. Nano Today 2022, 44, 101492.
15. Yang W. J., Deng H. Z., Zhu S. J., Lau J., Tian R., Wang S., Zhou Z. J., Yu G. C., Rao L., He L. C., Ma Y., Chen X. Y.* Size-Transformable Antigen-Presenting Cell Mimicking Nanovesicles Potentiate Effective Cancer Immunotherapy.Sci. Adv.2020, 6, eabd1631.
16. Yang W. J.,# Zhang F. W.,# Deng H. Z., Lin L. S., Wang S., Kang F., Yu G. C., Lau J., Tian R., Zhang M. R., Wang Z. T., He L. C., Ma Y., Niu G., Hu S.*, Chen X. Y.* Smart Nanovesicle Mediated Immunogenic Cell Death through Tumor Microenvironment Modulation for Effective Photodynamic Immunotherapy.ACS Nano2020, 14, 620-631.
17. Yang W. J., Zhu G. Z., Wang S., Yu G. C., Yang Z., Lin L. S., Zhou Z. J., Liu Y. J., Dai Y. L., Zhang F. W., Shen Z. Y., Liu Y., He Z. M., Lau J., Niu G., Kiesewetter D. O., Hu S.*, Chen X. Y.*In situ dendritic cell vaccine for effective cancer immunotherapy.ACS Nano2019, 13, 3083-3094.
18. Yang W. J., Zhou Z. J., Lau J., Hu S.*, Chen X. Y.* Functional T cell activation by smart nanosystems for effective cancer immunotherapy.Nano Today2019, 27, 28-47.
19. Xu X.#,Yang W. J.#, Liang Q. J., Shi Y. N., Zhang W. X., Wang X., Meng F. H., Zhong Z. Y.*, Yin L. C.* Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC). Nano Res. 2019, 12, 659-667.
20. Yang W. J.#, Wei Y. H.#, Yang L., Zhang J., Zhong Z. Y.*, Storm G., Meng F. H.* Granzyme B-loaded, cell-selective penetrating and reduction-responsive polymersomes effectively inhibit progression of orthotopic human lung tumor in vivo.J. Control. Release2018, 290, 141-149.
21. Yang W. J., Yang L., Xia Y. F., Cheng L.*, Zhang J., Meng F. H.*, Yuan J. D., Zhong Z. Y.* Lung cancer specific and reduction-responsive chimaeric polymersomes for highly efficient loading of pemetrexed and targeted suppression of lung tumor in vivo. Acta Biomater. 2018, 70, 177-185.
22. Yang W. J., Xia Y. F., Fang Y., Meng F. H.*, Zhang J., Cheng R., Deng C., Zhong Z. Y.* Selective cell penetrating peptide-functionalized polymersomes mediate efficient and targeted delivery of methotrexate disodium to human lung cancer in vivo.Adv. Healthc. Mater.2018, 7, 1701135.
23. Yang W. J., Xia Y. F., Zou Y., Meng F. H.*, Zhong Z. Y.* Bioresponsive chimaeric nano-polymersomes enable targeted and efficacious protein therapy for human lung cancersin vivo.Chem. Mater.2017, 29, 8757-8765.
24. Yang W. J., Zou Y., Meng F. H.*, Zhang J., Cheng R., Deng C., Zhong Z. Y.* Efficient and targeted suppression of human lung tumor xenografts in mice with methotrexate sodium encapsulated in all-function-in-one chimeric polymersomes.Adv. Mater.2016, 28, 8234-8239.