可逆交联纳米凝胶
当前位置:首页 > 研究方向 > 可逆交联纳米凝胶

微凝胶和纳米凝胶具有很好生物相容性,在生物组织工程、蛋白质药物缓慢释放、蛋白质药物肿瘤细胞内靶向释放等领域具有广泛的应用。但是,现有交联方法如自由基聚合和酶交联等需要引入引发剂或酶催化剂,可能导致细胞毒性和免疫原性等问题。通过巧妙利用硫辛酸开环聚合或通过光控四唑-烯点击化学法,我们制备得到了还原敏感可逆交联的透明质酸纳米凝胶,实现了化疗药物和蛋白质药物的肿瘤靶向释放。

代表性论文

1. W. Chen, Y. Zou, Z.Y. Zhong*, and R. Haag*, Cyclo(RGD)-decorated Redox-responsive Nanogels Mediate Targeted Chemotherapy of Integrin Over-expressing Human Glioblastoma In Vivo, Small 2017, DOI: 10.1002/smll.201601997.

2. J. Chen, Y. Zou, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Multifunctional Click Hyaluronic Acid Nanogels for Targeted Protein Delivery and Effective Cancer Treatment In Vivo, Chem. Mater. 2016, 28, 8792-8799.

3. Y.Q. Zhu, X.X. Wang, J. Chen, J. Zhang, F.H. Meng, C. Deng, R. Cheng, J. Feijen*, and Z.Y. Zhong*, Bioresponsive and fluorescent hyaluronic acid-iodixanol nanogels for targeted X-ray computed tomography imaging and chemotherapy of breast tumors, J. Control. Release 2016, 244, 229-239.

4. S. Li, J. Zhang, C. Deng*, F.H. Meng, L. Yu, and Z.Y. Zhong*, Redox-sensitive and intrinsically fluorescent photoclick hyaluronic acid nanogels for traceable and targeted delivery of cytochrome C to breast tumor in mice, ACS Appl. Mater. Interfaces 2016, 8, 21155-21162.

5. B.F. Sun, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Robust, active tumor-targeting and fast bioresponsive anticancer nanotherapeutics based on natural endogenous materials, Acta Biomaterialia 2016, 45, 223-233.

6. Y.N. Zhong, J. Zhang, R. Cheng*, C. Deng, F.H. Meng, F. Xie*, and Z.Y. Zhong*, Reversibly Crosslinked Hyaluronic Acid Nanoparticles for Active Targeting and Intelligent Delivery of Doxorubicin to Drug Resistant CD44+ Human Breast Tumor Xenografts, J. Control. Release 2015, 205, 144-154.

返回