功能可降解高分子
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生物可降解高分子材料(包括聚酯、聚碳酸酯、聚氨基酸等)是最重要的合成生物材料,广泛应用于控制药物释放、生物组织工程、医疗器械等。然而,现有的生物可降解高分子材料如聚丙交酯(PLA)、聚三亚甲基碳酸酯(PTMC)等因缺乏功能,往往不能满足生物医学应用的要求。我们从药物释放系统的需要出发,设计合成了含双硫五元环、双硫吡啶、丙烯酸酯、乙烯砜、缩醛等功能基团的新型环碳酸酯单体,制备了不同功能的生物可降解高分子材料和纳米药物载体。此外,通过功能氨基酸NCA单体或聚肽后修饰方式,我们设计制备得到了具不同功能的聚肽和聚肽纳米材料。

 

代表性著作

1. X.X. Wang, J. Zhang, R. Cheng*, F.H. Meng, C. Deng, and Z.Y. Zhong*, Facile synthesis of reductively degradable biopolymers using cystamine diisocyanate as a coupling agent, Biomacromolecules 2016, 17, 882-890.

2. J.T. Wu, J. Zhang, C. Deng*, F.H. Meng, and Z.Y. Zhong*, Vitamin E-Oligo(methyl diglycol L-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles, Biomacromolecules 2016, 17, 2367-2374.

3. Y. Zou, H. Meng, F.H. Meng*, C. Deng, J. Zhang, and Z.Y. Zhong*, Self-crosslinkable and intracellularly decrosslinkable biodegradable micellar nanoparticles: a robust, simple and multifunctional nanoplatform for high-efficiency targeted cancer chemotherapy, J. Control. Release 2016, 244, 326-335.

4. H.L. Sun, R. Cheng, C. Deng, F.H. Meng*, A.A. Dias, M. Hendriks, J. Feijen, and Z.Y. Zhong*, Enzymatically and Reductively Degradable a-Amino Acid-Based Poly(ester amide)s: Synthesis, Cell Compatibility, and Intracellular Anticancer Drug Delivery, Biomacromolecules 2015, 16, 597-605.

5. W. Chen, F.H. Meng, R. Cheng, C. Deng, J. Feijen*, and Z.Y. Zhong*, Advanced Drug and Gene Delivery Systems Based on Functional Biodegradable Polycarbonates and Copolymers, J. Control. Release 2014, 190, 398-414.

6. C. Deng, J.T. Wu, R. Cheng, F.H. Meng, H.A. Klok, and Z.Y. Zhong*, Functional Polypeptide and Hybrid Materials: Precision Synthesis via α-Amino Acid N-Carboxyanhydride Polymerization and Emerging Biomedical Applications, Prog. Polym. Sci. 2014, 39, 330-364. 

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