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钟志远 教授

钟志远,博士,教授,博导。1974年2月生,江西安远县人,苏州大学特聘教授,江苏特聘教授,美国化学会期刊Biomacromolecules(影响因子:5.246)副主编,国家杰出青年基金获得者,国家“万人计划”领军人才。苏州大学生物医用高分子材料重点实验室主任。1995年吉林工业大学(现吉林大学)获学士学位,1998年中国科学院长春应用化学研究所获硕士学位,2002年荷兰屯特大学获博士学位。2002-2007年荷兰屯特大学任助理教授。2007年4月起受聘为苏州大学特聘教授。2011-2012年担任苏州生物纳米园副总裁。研究领域涉及生物医用高分子材料、纳米药物(化学药物、蛋白质药物、RNA药物)、及肿瘤靶向治疗。在国际主流期刊发表论文180多篇,论文共被引用12000多次,H-因子60 (web of science),3篇论文入选“中国百篇最具影响国际学术论文”,入选2014、2015和2016年中国高被引学者榜单(材料科学领域)。申请了40项国家和国际发明专利(其中授权12项),11项专利技术已转让。近几年,应邀在重要国际学术会议上做邀请报告50多次。 

担任美国化学会期刊Biomacromolecules(影响因子:5.246)副主编,Journal of Controlled Release(IF 7.786)多期的客座主编,Materials Today (IF 21.695), Journal of Controlled Release (IF 7.786),Journal of Materials Chemistry B (IF 4.543),Nanotechnology (IF 3.44), Journal of Gene Medicine (IF 2.524), Nano Futures, Journal of Biomaterials Science Polymer Edition (IF 1.9), Materials Today Chemistry等国际期刊编委,国内期刊《中国科学:化学》及英文刊SCIENCE CHINA Chemistry (IF 4.132)青年编委,《药学学报》及英文刊Acta Pharmaceutica Sinica B编委,新型高分子材料与控制释放系列高水平国际学术会议(SIPCD 2010,2012,2014,2016)主席,国家自然科学基金委员会重大项目评审组专家,中国材料研究学会高分子材料与工程分会常务理事等。江苏省教育厅优秀科技创新团队带头人。 

获得了美国化学会的“生物大分子/大分子青年研究者奖”(2014)、德国洪堡基金会“贝塞尔研究奖”(2013)、日本和美国控制释放学会共同颁发的 “亚洲药物释放系统突破技术奖”(2013)等国际奖励。入选国家“万人计划”创新领军人才、国家杰出青年科学基金获得者(杰青结题特优)、国家百千万人才工程并授予“有突出贡献中青年专家”荣誉称号、科技部中青年科技创新领军人才、江苏特聘教授、江苏省333工程第二层次培养对象、苏州市十佳魅力科技人物等。享受国务院政府特殊津贴。 

代表性著作 

1. Y. Zou, Y.H. Wei, G.L. Wang, F.H. Meng*, M.Y. Gao, G. Storm, and Z.Y. Zhong*, Nano-Polymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo, Adv. Mater. 2017, 29, 1603997 (DOI: 10.1002/adma.201603997)

2. J.T. Wu, C. Deng*, F.H. Meng, J. Zhang, H.L. Sun, and Z.Y. Zhong*, Hyaluronic acid coated PLGA nanoparticulate docetaxel effectively targets and suppresses orthotopic human lung cancer, J. Control. Release 2017,  http://dx.doi.org/10.1016/j.jconrel.2016.12.024

3. P. Zhong, H. Meng, J. Qiu, J. Zhang, H.L. Sun, R. Cheng*, and Z.Y. Zhong*,αvβ3 Integrin-Targeted Reduction-Sensitive Micellar Mertansine Prodrug: Superb Drug Loading, Enhanced Stability, and Effective Inhibition of Melanoma Growth In Vivo, J. Control. Release 2017,  DOI: 10.1016/j.jconrel.2016.12.011

4. N. Zhang, Y.F. Xia, Y. Zou, W.J. Yang, J. Zhang, Z.Y. Zhong*, and F.H. Meng*, ATN-161 Peptide Functionalized Reversibly Crosslinked Polymersomes Mediate Targeted Doxorubicin Delivery into Melanoma-Bearing C57BL/6 Mice, Mol. Pharm. 2017, DOI: 10.1021/acs.molpharmaceut.6b00800

5. Y. Fang, Y. Jiang, Y. Zou, F.H. Meng*, J. Zhang, C. Deng, H.L. Sun and Z.Y. Zhong*, Targeted glioma chemotherapy by cyclic RGD peptide-functionalized reversibly core-crosslinked multifunctional poly(ethylene glycol)-b-poly(e-caprolactone) micelles, Acta Biomaterialia 2017, 50, 396–406.

6. Y.Q. Zhu, X.X. Wang, J. Zhang, F.H. Meng, C. Deng, R. Cheng, J. Feijen*, and Z.Y. Zhong*, Exogenous vitamin C boosts the antitumor efficacy of paclitaxel containing reduction-sensitive shell-sheddable micelles in vivo, J. Control. Release 2017, 250, 9-19.

7. J.T. Wu, J. Zhang, C. Deng*, F.H. Meng, R. Cheng, and Z.Y. Zhong*, Robust, Responsive and Targeted PLGA Anticancer Nanomedicines by Combining Reductively Cleavable Surfactant and Covalent Hyaluronic Acid Coating, ACS Appl. Mater. Interfaces 2017, 9, 3985-3994.

8. W. Chen, Y. Zou, Z.Y. Zhong*, and R. Haag *, Cyclo(RGD)-decorated Redox-responsive Nanogels Mediate Targeted Chemotherapy of Integrin Over-expressing Human Glioblastoma In Vivo, Small 2017, 13, 1601997.

9. J. Chen, Y. Zou, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Multifunctional Click Hyaluronic Acid Nanogels for Targeted Protein Delivery and Effective Cancer Treatment In Vivo, Chem. Mater. 2016, 28, 8792-8799.

10. P. Zhong, J. Zhang, C. Deng, R. Cheng*, F.H. Meng, and Z.Y. Zhong*, Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy, Biomacromolecules 2016, 17, 3602-3608.

11. Y.N. Zhong, M. Dimde, D. Stöbener, F.H. Meng*, C. Deng, Z.Y. Zhong*, and R. Haag, Micelles with Sheddable Dendritic Polyglycerol Sulfate Shells Show Extraordinary Tumor Targetability and Chemotherapy In Vivo, ACS Appl. Mater. Interfaces 2016, 8, 27530-27538.

12. W.J. Yang, Y. Zou, F.H. Meng*, J. Zhang, R. Cheng, C. Deng, and Z.Y. Zhong*, Efficient and targeted suppression of human lung tumor xenografts in mice with methotrexate sodium encapsulated in all-function-in-one chimaeric polymersomes, Adv. Mater. 2016, 28, 8234-8239.

13. Y.Q. Zhu, X.X. Wang, J. Chen, J. Zhang, F.H. Meng, C. Deng, R. Cheng, J. Feijen*, and Z.Y. Zhong*, Bioresponsive and fluorescent hyaluronic acid-iodixanol nanogels for targeted X-ray computed tomography imaging and chemotherapy of breast tumors, J. Control. Release 2016, 244, 229-239.

14. Y. Zou, F.H. Meng*, C. Deng, and Z.Y. Zhong*, Robust, tumor-homing and redox-sensitive polymersomal doxorubicin: A superior alternative to Doxil and Caelyx? J. Control. Release 2016, 239, 149-158.

15. S. Li, J. Zhang, C. Deng*, F.H. Meng, L. Yu, and Z.Y. Zhong*, Redox-sensitive and intrinsically fluorescent photoclick hyaluronic acid nanogels for traceable and targeted delivery of cytochrome C to breast tumor in mice, ACS Appl. Mater. Interfaces 2016, 8, 21155-21162

16. B.F. Sun, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Robust, active tumor-targeting and fast bioresponsive anticancer nanotherapeutics based on natural endogenous materials, Acta Biomaterialia 2016, 45, 223-233.

17. J.T. Wu, J. Zhang, C. Deng*, F.H. Meng, and Z.Y. Zhong*, Vitamin E-Oligo(methyl diglycol L-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles, Biomacromolecules 2016, 17, 2367-2374

18. Y. Zou, H. Meng, F.H. Meng*, C. Deng, J. Zhang, and Z.Y. Zhong*, Self-crosslinkable and intracellularly decrosslinkable biodegradable micellar nanoparticles: a robust, simple and multifunctional nanoplatform for high-efficiency targeted cancer chemotherapy, J. Control. Release 2016, 244, 326-335.

19. Y.Q. Zhu, J. Zhang*, F.H. Meng, C. Deng, R. Cheng, J. Feijen*, and Z.Y. Zhong*, cRGD-functionalized reduction-sensitive shell-sheddable biodegradable micelles mediate enhanced doxorubicin delivery to human glioma xenografts in vivo, J. Control. Release 2016, 233, 29-38.

20. X.X. Wang, J. Zhang, R. Cheng*, F.H. Meng, C. Deng, and Z.Y. Zhong*, Facile synthesis of reductively degradable biopolymers using cystamine diisocyanate as a coupling agent, Biomacromolecules 2016, 17, 882-890.

21. Y.N. Zhong, K. Goltsche, L. Cheng, F. Xie, F.H. Meng*, C. Deng, Z.Y. Zhong*, and R. Haag, Hyaluronic acid-shelled acid-activatable paclitaxel prodrug micelles effectively target and treat CD44-overexpressing human breast tumor xenografts in vivo, Biomaterials 2016, 84, 250-261.

22. X. Li, W.J. Yang, Y. Zou, F.H. Meng*, C. Deng, and Z.Y. Zhong*, Efficacious delivery of protein drugs to prostate cancer cells by PSMA-targeted pH-responsive chimaeric polymersomes, J. Control. Release 2015, 220, 704-714.

23. R. Cheng, F.H. Meng, C. Deng, and Z.Y. Zhong*, Bioresponsive Polymeric Nanotherapeutics for Targeted Cancer Chemotherapy, Nano Today 2015, 10, 656-670.

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