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程茹 副教授

程茹,博士,副教授,硕导。 2005年南京工业大学获博士学位,2006-2007年中科院南京土壤研究所博士后,2007年受聘为苏州大学讲师,2012年晋升为副教授。2011年10月到2012年3月在瑞士洛桑联邦理工做访问学者。2013年10月开始在美国康奈尔大学做访问学者,为期一年。在国际主流期刊上发表论文  60多篇,他引2900多次。主持两项国家自然科学基金和两项江苏省自然科学基金。主要研究方向为功能性生物可降解高分子材料的设计合成、生物响应性纳米药物载体。 

代表性著作

1. R. Cheng, F. Feng, F. Meng, C. Deng, J. Feijen, Z. Zhong, Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. J. Control. Release. 152 (2011) 2-12.

2. R. Cheng, F. Meng, S. Ma, H. Xu, H. Liu, X. Jing, et al., Reduction and temperature dual-responsive crosslinked polymersomes for targeted intracellular protein delivery. J. Mater. Chem. 21 (2011) 19013-19020.

3. R. Cheng, X. Wang, W. Chen, F. Meng, C. Deng, H. Liu, et al., Biodegradable poly(epsilon-caprolactone)-g-poly(2-hydroxyethyl methacrylate) graft copolymer micelles as superior nano-carriers for "smart" doxorubicin release. J. Mater. Chem. 22 (2012) 11730-11738.

4. R. Cheng, F. Meng, C. Deng, H.-A. Klok, Z. Zhong, Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery. Biomaterials. 34 (2013) 3647-3657.

5. R. Cheng, F. Meng, C. Deng, Z. Zhong, Bioresponsive polymeric nanotherapeutics for targeted cancer chemotherapy. Nano Today. 10 (2015) 656-670.

6. F. Huang, R. Cheng*, F. Meng, C. Deng, Z. Zhong*, Micelles Based on Acid Degradable Poly(acetal urethane): Preparation, pH-Sensitivity, and Triggered Intracellular Drug Release. Biomacromolecules. 16 (2015) 2228-2236.

7. W. Lu, X. Wang, R. Cheng*, C. Deng, F. Meng, Z. Zhong*, Biocompatible and bioreducible micelles fabricated from novel alpha-amino acid-based poly(disulfide urethane)s: design, synthesis and triggered doxorubicin release. Polym. Chem. 6 (2015) 6001-6010.

8. Y. Zhong, J. Zhang, R. Cheng*, C. Deng, F. Meng, F. Xie*, et al., Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+human breast tumor xenografts. J. Control. Release. 205 (2015) 144-154.

9. X. Wang, J. Zhang, R. Cheng*, F. Meng, C. Deng, Z. Zhong*, Facile Synthesis of Reductively Degradable Biopolymers Using Cystamine Diisocyanate as a Coupling Agent. Biomacromolecules. 17 (2016) 882-890.

10. P. Zhong, J. Zhang, C. Deng, R. Cheng*, F. Meng, Z. Zhong*, Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy. Biomacromolecules. 17 (2016) 3602-3608. 

11. P. Zhong, H. Meng, J. Qiu, J. Zhang, H. Sun, R. Cheng*, et al., αvβ3 Integrin-targeted reduction-sensitive micellar mertansine prodrug: Superb drug loading, enhanced stability, and effective inhibition of melanoma growth in vivo. J. Control. Release. 259 (2017) 176-186.

12. P. Zhong, M. Qiu, J. Zhang, H. Sun, R. Cheng*, C. Deng, F. Meng, Z. Zhong*, cRGD-installed docetaxel-loaded mertansine prodrug micelles: redox-triggered ratiometric dual drug release and targeted synergistic treatment of B16F10 melanoma. Nanotechnology. 28 (2017) 295103.

13. K. Wu, R. Cheng*, J. Zhang, F. Meng, C. Deng, Z. Zhong*, Micellar nanoformulation of lipophilized bortezomib: high drug loading, improved tolerability and targeted treatment of triple negative breast cancer. J. Mater. Chem. B. 5 (2017) 5658-5667.

14. J. Qiu, R. Cheng*, J. Zhang, H. Sun, C. Deng, F. Meng, Z. Zhong*, Glutathione-Sensitive Hyaluronic Acid-Mercaptopurine Prodrug Linked via Carbonyl Vinyl Sulfide: A Robust and CD44-Targeted Nanomedicine for Leukemia. Biomacromolecules. Doi:10.1021/acs.biomac.7b00846 (2017).

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