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孟凤华 教授

孟凤华,博士,教授,博导。 2003年荷兰屯特大学获博士学位,2005-2007年荷兰屯特大学博士后,2007年受聘为苏州大学副教授、硕导,2010年晋升为教授、博导。在国际主流期刊上发表SCI论文100多篇, 被他引5800多次。H-因子44(截止2016年11月15日)。现主持一项国家自然科学基金委中荷国际合作项目、两项国家自然科学基金面上项目、一项省重大自然科学基金及一项教育部博士点基金。主要研究方向为智能聚合物纳米载体、蛋白质的控制释放、癌症的诊断及靶向治疗。

代表性论著

1. Y. Zou, Y.H. Wei, G.L. Wang, F.H. Meng*, M.Y. Gao, G. Storm, and Z.Y. Zhong*, Nano-Polymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo, Adv. Mater. 2017 http://dx.doi.org/10.1002/adma.201603997.

2. Y. Fang, Y. Jiang, Y. Zou, F.H. Meng*, J. Zhang, C. Deng, H.L. Sun and Z.Y. Zhong*, Targeted glioma chemotherapy by cyclic RGD peptide-functionalized reversibly core-crosslinked multifunctional poly(ethylene glycol)-b-poly(e-caprolactone) micelles, Acta Biomaterialia 2017, http://dx.doi.org/10.1016/j.actbio.2017.01.007.

3. N. Zhang, Y.F. Xia, Y. Zou, W.J. Yang, J. Zhang, Z.Y. Zhong*, and F.H. Meng*, ATN-161 Peptide Functionalized Reversibly Crosslinked Polymersomes Mediate Targeted Doxorubicin Delivery into Melanoma-Bearing C57BL/6 Mice, Mol. Pharm. 2017, DOI: 10.1021/acs.molpharmaceut.6b00800.

4. Y. Zou, Y. Fang, H. Meng, F.H. Meng*, C. Deng, J. Zhang and Z.Y. Zhong*, Self-Crosslinkable and Intracellularly Decrosslinkable Biodegradable Micelles: A Robust, Simple and Multifunctional Nanoplatform for High-Efficiency Targeted Cancer Chemotherapy, J. Control. Release 2016, 244, 326-335.

5. Y.N. Zhong, M. Dimde, D. Stöbener, F.H. Meng*, C. Deng, Z.Y. Zhong*, and R. Haag, Micelles with Sheddable Dendritic Polyglycerol Sulfate Shells Show Extraordinary Tumor Targetability and Chemotherapy In Vivo, ACS Appl. Mater. Interfaces 2016, 8, 27530-27538.

6. W.J. Yang, Y. Zou, F.H. Meng*, J. Zhang, R. Cheng, C. Deng, and Z.Y. Zhong*, Efficient and targeted suppression of human lung tumor xenografts in mice with methotrexate sodium encapsulated in all-function-in-one chimaeric polymersomes, Adv. Mater. 2016, 28 (37), 8234-8239.

7. Y.N. Zhong, K. Goltsche, L. Cheng, F. Xie, F.H. Meng*, C. Deng, Z.Y. Zhong*, and R. Haag, Hyaluronic acid-shelled acid-activatable paclitaxel prodrug micelles effectively target and treat CD44-overexpressing human breast tumor xenografts in vivo, Biomaterials 2016, 84, 250-261.

8. Y. Zou, F.H. Meng*, C. Deng, and Z.Y. Zhong*, Robust, Tumor-Homing and Redox-Sensitive Polymersomal Doxorubicin: A Superior Alternative to Doxil and Caelyx? J. Control. Release 2016, 239, 149-158.

9. X. Li, W.J. Yang, Y. Zou, F.H. Meng*, C. Deng, and Z.Y. Zhong*, Efficacious delivery of protein drugs to prostate cancer cells by PSMA-targeted pH-responsive chimaeric polymersomes, J. Control. Release 2015, 220, 704-714.

10. L. Lu, Y. Zou, W.J. Yang, F.H. Meng*, C. Deng, R. Cheng, and Z.Y. Zhong*, Anisamide-Decorated pH-Sensitive Degradable Chimaeric Polymersomes Mediate Potent and Targeted Protein Delivery to Lung Cancer Cells, Biomacromolecules 2015, 16(6), 1726-1735.

11. J.L. Lv, H.L. Sun, Y. Zou, F.H. Meng*, A.A. Dias, M. Hendriks, J. Feijen and Z.Y. Zhong*, Reduction degradable amino acid-based poly-(ester amide)-graft-galactose copolymers: facile synthesis, self-assembly, and hepatoma targeting doxorubicin delivery. Biomaterials Science, 2015, 3, 1134-1146.

12. H.L. Sun, R. Cheng, C. Deng, F.H. Meng*, A.A. Dias, M. Hendriks, J. Feijen, and Z.Y. Zhong*, Enzymatically and Reductively Degradable a-Amino Acid-Based Poly(ester amide)s: Synthesis, Cell Compatibility, and Intracellular Anticancer Drug Delivery, Biomacromolecules 2015, 16, 597-605.

13. Y.N. Zhong, C. Wang, R. Cheng, L. Cheng, F.H. Meng*, Z. Liu*, Z.Y. Zhong*, and R. Haag, cRGD-Directed, NIR-Responsive and Robust AuNR/PEG-PCL Hybrid Nanoparticles for Targeted Chemotherapy of Glioblastoma In Vivo, J. Control. Release 2014, 195, 63-71.

14. Y. Zou, Y. Song, W.J. Yang, F.H. Meng*, H. Y. Liu, and Z.Y. Zhong*, Galactose-Installed Photo-Crosslinked pH-Sensitive Degradable Micelles for Active Targeting Chemotherapy of Hepatocellular Carcinoma in Mice, J. Control. Release 2014, 193, 154-161.

15. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, Z.Y. Zhong*, Reduction-Responsive Polymeric Micelles and Vesicles for Triggered Intracellular Drug Release, Antioxidants & Redox Signaling 2014, 21, 755-767 (invited review).

16. F.H. Meng, Y.N. Zhong, R. Cheng, C. Deng, Z.Y. Zhong*, pH-Sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: concept and recent advances, Nanomedicine, 2014, 9, 487-499 (invited review).

17. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, Z.Y. Zhong*, Reduction and pH dual-bioresponsive crosslinked polymersomes for efficient intracellular delivery of proteins and potent induction of cancer cell apoptosis. Acta Biomaterialia 2014, 10, 2159-2168.

18. X.Y. Wang, H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, Z.Y. Zhong*, Galactose-Decorated Reduction-Sensitive Degradable Chimaeric Polymersomes as a Multifunctional Nanocarrier to Efficiently Chaperone Apoptotic Proteins into Hepatoma Cells. Biomacromolecules, 2013, 14, 2873–2882.

19. Y.D. Gu, Y.N. Zhong, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Acetal-Linked Paclitaxel Prodrug Micellar Nanoparticles as a Versatile and Potent Platform for Cancer Therapy, Biomacromolecules, 2013, 14, 2772–2780.

20. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, Z.Y. Zhong*, Reduction-sensitive degradable micellar nanoparticles as smart and intuitive delivery systems for cancer chemotherapy. Expert Opinion on Drug Delivery 2013, 10, 1109-1022. (invited review).

21. W. Chen, P. Zhong, F.H. Meng*, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Redox and pH-Responsive Degradable Micelles for Dually Activated Intracellular Anticancer Drug Release, J. Control. Release 2013, 169, 171–179.

22. F.H. Meng, R. Cheng, C. Deng, Z.Y. Zhong*, Intracellular Drug Release Nanosystems, Mater. Today 2012, 15, 436-442. (invited review).

23. Y.L. Wu, W. Chen, F.H. Meng*, Z.J. Wang, R. Cheng, C. Deng, H.Y. Liu, Z.Y. Zhong*, Core-crosslinked pH-sensitive degradable micelles: A promising approach to resolve the extracellular stability versus intracellular drug release dilemma, J. Controlled Release 2012 , 164,338-345.

24. S.K. Li, F.H. Meng, Z.J. Wang, Y.N. Zhong, M. Zheng, H.Y. Liu, Z.Y. Zhong*, Biodegradable Polymersomes with an Ionizable Membrane: Facile Preparation, Superior Protein Loading and Endosomal pH-Responsive Protein Release, Eur. J. Pharm. Biopharm. 2012, 82, 103-111. (invited article).

25. W. Wang, H.L. Sun, F.H. Meng, S.B. Ma, H.Y. Liu, and Z.Y. Zhong*, Precise Control of Intracellular Drug Release and Anti-Tumor Activity of Biodegradable Micellar Drugs Via Reduction-Sensitive Shell-Shedding, Soft Matter, 2012, 8, 3949-3956.

26. J.C. Zhang, L.L. Wu, F.H. Meng, Z.J. Wang, H.Y. Liu, and Z.Y. Zhong*, pH and Reduction Dual-Bioresponsive Polymersomes for Efficient Intracellular Protein Delivery, Langmuir, 2012, 28, 2056-2065 (invited article).

27. F.H. Meng, and Z.Y. Zhong*, Polymersomes Spanning from Nano to Micro Scales: Advanced Vehicles for Controlled Drug Delivery and Robust Vesicles for Virus and Cell-Mimicking, J. Phys. Chem. Letters 2011, 2, 1533-1539. (Invited Perspective).

28. J. Xiong, F.H. Meng, C. Wang, R. Cheng, Z. Liu, and Z.Y. Zhong*, Folate-Conjugated Crosslinked Biodegradable Micelles for Receptor-Mediated Delivery of Paclitaxel, J. Mater. Chem. 2011, 21, 5786-5794.

29. R. Yang, F.H. Meng, S.B. Ma, F.S. Huang, H.Y. Liu, and Z.Y. Zhong*, Galactose-Decorated Crosslinked Biodegradable Poly(Ethylene Glycol)-b-Poly(ε-Caprolactone) Block Copolymer Micelles for Enhanced Hepatoma-Targeting Delivery of Paclitaxel, Biomacromolecules 2011, 12, 3047–3055.

30. R. Cheng, F.H. Meng, S.B. Ma, H.F. Xu, H.Y. Liu, X.B. Jing, and Z.Y. Zhong*, Reduction and Temperature Dual-Responsive Crosslinked Polymersomes for Targeted Intracellular Protein Delivery, J. Mater. Chem. 2011, 21 (47), 19013 - 19020.

31. H.L. Sun, F.H. Meng, A.A. Dias, M. Hendriks, J. Feijen, and Z.Y. Zhong*, a-Amino Acid Containing Degradable Polymers as Functional Biomaterials: Rational Design, Synthetic Pathway and Biomedical Applications, Biomacromolecules 2011, 12, 1937-1955.

32. G.J. Liu, S.B. Ma, S.K. Li, R. Cheng, F.H. Meng*, H.Y. Liu, Z.Y. Zhong*, The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes, Biomaterials 2010, 31, 7575-7585.

33. H.L. Sun, F.H. Meng*, B.N. Guo, X.Q. Li, R. Cheng, H.Y. Liu, and Z.Y. Zhong*, Shell-sheddable micelles based on dextran-ss-poly(e-caprolactone) diblock copolymer for efficient intracellular release of doxorubicin, Biomacromolecules 2010, 11, 848–854.

34. W. Chen, F.H. Meng*, R. Cheng, and Z.Y. Zhong*, pH-Sensitive Degradable Polymersomes for Triggered Release of Anticancer Drugs: a Comparative Study with Micelles, J. Control. Release 2010, 142, 40-46.

35. W. Chen, H.C. Yang, R. Wang, R. Cheng, F.H. Meng*, W.X. Wei, and Z.Y. Zhong*, Versatile Synthesis of Functional Biodegradable Polymers by Combining Ring-Opening Polymerization and Postpolymerization Modification via Michael-Type Addition Reaction, Macromolecules 2010, 43, 201–207.

36. J.S. Lee, W. Zhou, F.H. Meng, J.Feijen, Thermosensitive hydrogel-containing polymersomes for controlled drug delivery, J. Control. Release 2010, 146, 400-408.

37. Y.L. Li, L. Zhu, Z.Z. Liu, R. Cheng, F.H. Meng*, J.H. Cui, S.J. Ji, and Z.Y. Zhong*, Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells, Angew. Chem. Int. Ed. 2009, 48, 9914-9918.

38. Y.M. Xu, F.H. Meng*, R. Cheng, Z.Y. Zhong*, Reduction-Sensitive Reversibly Crosslinked Biodegradable Micelles for Triggered Release of Doxorubicin, Macromol. Biosci. 2009, 9, 1254-1261.

39. H.L. Sun, B.N. Guo, R. Cheng, F.H. Meng*, H.Y. Liu, Z.Y. Zhong*, Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin, Biomaterials 2009, 30, 6358-6366.

40. H.F. Xu, F.H. Meng*, Z.Y. Zhong*, Reversibly crosslinked temperature-responsive nano-sized polymersomes: synthesis and triggered drug release, J. Mater. Chem. 2009, 19: 4183-4190.

41. F.H. Meng, W.E.Hennink, Z.Y. Zhong*, Reduction-Sensitive Polymers and Bioconjugates for Biomedical Applications, Biomaterials 2009, 30, 2180-2198.

42. F.H. Meng, Z.Y. Zhong*, J. Feijen, Stimuli-responsive polymersomes for programmed drug delivery. Biomacromolecules 2009, 10, 197-209.

43. F.H. Meng, G.H.M. Engbers, J. Feijen, Biodegradable polymersomes as a basis for artificial cells: encapsulation, release and targeting. J. Controlled Release, 2005, 101, 187-198.

44. F.H. Meng, G.H.M. Engbers, J.Feijen, Polyethylene glycol-grafted polystyrene particles. J. Biomed. Mater. Res., 2004, 70A, 49-58.

45. F.H. Meng, G.H.M. Engbers, A. Gessner, R.H. Müller, J. Feijen, Pegylated polystyrene particles as a model system for artificial cells. J. Biomed. Mater. Res., 2004, 70A, 97-106.
46. F.H. Meng, C. Hiemstra, G.H.M. Engbers, J. Feijen, Biodegradable polymersomes. Macromolecules 2003, 36, 3004-3006.

47. F.H. Meng, G.H.M. Engbers, J.Feijen, Preparation and in vitro evaluation of polyethylene glycol modified microspheres. J. Controlled Release 2003, 87, 243-245.

48. F.H. Meng, G.Q. Yu, B.T. Huang, Polymer-supported zirconocene catalyst for ethylene polymerization. J. Polym. Sci. Part A: Polym. Chem. 1999, 37, 37-46.

专利

 1.  孟凤华,徐海飞,钟志远,界面交联的温度敏感的聚合物囊泡及其应用。授权专利号:ZL 2009 1 0030113.5. 授权公告日:2011年7月20日。

2.  李玉玲,刘兆忠,周磊,孟凤华,钟志远,侧链用硫辛酸修饰的亲水性聚合物及其制备和应用。授权专利号:ZL 2009 1 0181922.6. 授权公告日:2011年9月28日。(已转让)

3.  朱彩虹,罗思彬,孟凤华,朱秀林,钟志远,生物可降解阳离子聚合物及其应用。授权专利号:ZL 2009 1 0232056.9. 授权公告日:2011年11月30日。

4.  刘桂景,李少科,孟凤华,钟志远, 生物可降解聚合物囊泡及其制备和应用。授权专利号:ZL 2009 1 0264247.3. 授权公告日:2012年5月23日。

5.  钟志远,刘兆忠,郑蒙,孟凤华,一种疏水基团修饰的聚乙烯亚胺衍生物及其应用。授权专利号:ZL 2011 1 0046746.2. 授权公告日:2012年12月5日。

6.  钟志远, 李玉玲,刘兆忠,周磊,孟凤华,一种侧链用硫辛酸修饰的亲水性聚合物。授权专利号:ZL 2011 1 0110986.4.。授权公告日:2013年2月13日。(已转让)

7.  陈维,王荣,孟凤华,钟志远,含有丙烯酸酯类功能基团的环碳酸酯单体及其制备和应用。授权专利号:ZL 2009 1 0181912.2。授权公告日:2013年10月9日。

8.  孟凤华,李少科,杨瑞,钟志远,一种双亲性聚合物构成的囊泡及其应用。授权专利号:ZL 2012 1 0158187.9。授权公告日:2014年4月1日。

9.  钟志远,孟凤华,杜银锋,陈维,一种酸敏感可降解聚合物囊泡及其制备和应用。授权专利号:ZL 2012 1 0231361.8.。授权公告日:2014年10月30日。

10. 孟凤华,顾裕丹,钟志远,一种酸敏感聚合物前药、其纳米粒及该纳米粒的应用,授权专利号:ZL 2013 1 0241009.7;授权公告日:2014年11月6日。

11. 邓超,孟凤华,程茹,钟志远,乙烯砜取代的半胱氨酸-N-羧基内酸酐、其聚合物及聚合物的应用,授权专利号:2013 1 0206285.X;授权公告日:2015年3月25日。

12. 邓超、范亚萍、孟凤华、程茹、钟志远 ,一种水凝胶、其制备方法及应用 ,江苏, 中华人民共和国国家产权局, 授权专利号:ZL 2013 1 0274019.0,授权公告日:2015年4月29日

13. 孟凤华,邹艳,钟志远,含双硫五元环功能基团的环状碳酸酯单体及其制备方法,授权专利号: ZL 2014 1 0231697.3;专利申请日:2014年5月29日;授权公告日:2016年3月30日。(已转让)

14. 孟凤华,邹艳,钟志远,侧链含双硫五元环功能基团的碳酸酯聚合物及其应用,授权专利号: ZL 2014 1 0231049.8;专利申请日:2014年5月29日; 授权公告日:2016年9月7日。(已转让)

15. 钟志远,钟伊南, 孟凤华,基于透明质酸的两亲聚合物、其制备方法与应用,专利申请号:201510006737.9;专利申请日:2015年1月8日。(已转让)

16. 钟志远,邹艳, 孟凤华,一种含双碘环碳酸酯化合物及其制备方法,专利申请号:201510077770.0;专利申请日:2015年3月18日。

17. 钟志远,邹艳, 孟凤华,一种侧链含双碘功能基团的生物可降解聚合物及其应用,专利申请号:201510077784.2;专利申请日:2015年3月18日。

18. 孟凤华,邹艳,钟志远,含双硫五元环功能基团的环状碳酸酯单体及其制备方法,专利申请号:PCT/CN2015/079998; filing date:2015年5月27日。 Publishing date: 2015年12月3日( PCT/WO2015/180655). (已转让)已进入国家

19. 孟凤华,邹艳,钟志远,侧链含双硫五元环功能基团的碳酸酯聚合物及其应用,专利申请号:PCT/CN2015/080000; filing date:2015年5月27日。 Publishing date: 2015年12月3日( PCT/WO 2015/180656). (已转让)已进入国家

20. 孟凤华,邹艳,钟志远,侧链含双硫五元环功能基团的碳酸酯聚合物的应用,专利申请号:201510973700.3;专利申请日:2015年12月24日。(已转让)

21. 孟凤华,邹艳,钟志远,一种侧链含双硫五元环功能基团的碳酸酯聚合物在制备药物控制释放载体中的应用;专利申请号:201510973768.1;专利申请日:2015年12月24日。(已转让)

22. 孟凤华,邹艳,方媛,钟志远,生物可降解双亲性聚合物、由其制备的聚合物囊泡及在制备肺癌靶向治疗药物中的应用;专利申请号:201510973770.9;专利申请日:2015年12月24日。(已转让)

23. 钟志远,邹艳,魏耀华,孟凤华,含双碘环碳酸酯单体、由其制备的生物可降解聚合物及应用,专利申请号:PCT/CN2016/073743;专利申请日:2016年2月12日。

24. 钟志远,邹艳,孟凤华,一种侧链含双碘功能基团的生物可降解聚合物及其应用,专利申请号:201610078843.2;专利申请日:2016年2月4日。 (分案申请)

25. 孟凤华,邹艳,钟志远,卵巢癌特异靶向的生物可降解双亲性聚合物、由其制备的聚合物囊泡及应用;专利申请号:201610123977.1;专利申请日:2016年3月7日。(已转让)

26. 孟凤华,杨炜静,钟志远,侧链含硫辛酰基的聚合物、其制备方法及由其制备的聚合物囊泡及其应用,专利申请号:201610234759.5;专利申请日:2016年4月18日。

27. 邓超,武金田,孟凤华,钟志远,基于疏水功能性小分子-亲水聚氨基酸的生物可降解聚合物及其制备方法和应用,专利申请号:201610307256.6;专利申请日:2016年5月10日。

28. 邓超,武金田,孟凤华,钟志远,基于聚氨基酸的功能性生物可降解纳米粒子的制备方法,专利申请号:201610307271.0;专利申请日:2016年5月10日。

29. 邓超,武金田,孟凤华,钟志远,基于聚氨基酸的功能性生物可降解纳米粒子的制备方法,专利申请号:PCT/CN2016/081619;专利申请日:2016年5月10日。

30. 邓超,陈景,孟凤华,钟志远,一种自发荧光纳米凝胶及其制备方法与应用,专利申请号:201610536475.1;专利申请日:2016年7月8日。

31. 邓超,陈景,孟凤华,钟志远,一种抗肿瘤药物的制备方法,专利申请号:201610536411.1;专利申请日:2016年7月8日。

32. 邓超,陈景,孟凤华,钟志远,一种抗肿瘤药物的制备方法,专利申请号:PCT/CN2016/089507;专利申请日:2016年7月10日。

33. 孟凤华,邹艳,杨炜静,孟浩、钟志远,具有不对称膜结构的可逆交联生物可降解聚合物囊泡及其制备方法与在核酸药物中的应用,专利申请号:201610501766.7;专利申请日:2016年6月30日。

34. 孟凤华,杨炜静、方媛、邹艳、钟志远,一种基于交联生物可降解聚合物囊泡的抗肿瘤纳米药物及其制备方法,专利申请号:201610559279.6;专利申请日:2016年7月15日。

35. 孟凤华、方媛、杨炜静、邹艳、钟志远,内膜具有正电的可逆交联生物可降解聚合物囊泡及其制备方法与在制备抗肿瘤药物中的应用,专利申请号:201610558116.6;专利申请日:2016年7月15日。

 

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