Nano-polymersomal contrast agent
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Lack of early diagnosis poses a significant challenge for cancer treatment. Here, we have designed a novel diiodine-functionalized trimethylene carbonate monomer, based on which we have developed nanopolymersomes with an ultrahigh iodine content as a nano-CT contrast agent for targeted CT imaging of various tumors in vivo. These iodine-rich nanopolymersomes might overcome the drawbacks of current iodinated small molecule contrast agents such as high osmolality and viscosity, potential renal failure risk, and possible iodine hypersensitivity. By loading Gd into polymersomes, we will develop tumor-targeted MRI contrast agent.

Representative Papers

1. Y. Zou, Y.H. Wei, G.L. Wang, F.H. Meng*, M.Y. Gao, G. Storm, and Z.Y. Zhong*, Nano-Polymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo, Adv. Mater. 2017,