Reversibly crosslinked nanogels
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Microgels and nanogels with excellent biocompatibility have a tremendous potential in tissue engineering, sustained protein release, and tumor-targeted protein delivery applications. However, current crosslinking methods such as radical polymerization and enzymatic crosslinking require use of initiators or enzyme catalyst, which possibly lead to cytotoxic effect or immunogenicity problems. Here, taking advantages of ring-opening polymerization feature of lipoic acid or tetrazole-ene photo-click chemistry, we have prepared reduction-sensitive reversibly crosslinked hyaluronic acid nanogels that mediate tumor-targeted delivery of chemotherapeutics as well as protein drugs.

Representative Papers

1. W. Chen, Y. Zou, Z.Y. Zhong*, and R. Haag*, Cyclo(RGD)-decorated Redox-responsive Nanogels Mediate Targeted Chemotherapy of Integrin Over-expressing Human Glioblastoma In Vivo, Small 2017, DOI: 10.1002/smll.201601997.

2. J. Chen, Y. Zou, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Multifunctional Click Hyaluronic Acid Nanogels for Targeted Protein Delivery and Effective Cancer Treatment In Vivo, Chem. Mater. 2016, 28, 8792-8799.

3. Y.Q. Zhu, X.X. Wang, J. Chen, J. Zhang, F.H. Meng, C. Deng, R. Cheng, J. Feijen*, and Z.Y. Zhong*, Bioresponsive and fluorescent hyaluronic acid-iodixanol nanogels for targeted X-ray computed tomography imaging and chemotherapy of breast tumors, J. Control. Release 2016, 244, 229-239.

4. S. Li, J. Zhang, C. Deng*, F.H. Meng, L. Yu, and Z.Y. Zhong*, Redox-sensitive and intrinsically fluorescent photoclick hyaluronic acid nanogels for traceable and targeted delivery of cytochrome C to breast tumor in mice, ACS Appl. Mater. Interfaces 2016, 8, 21155-21162.

5. B.F. Sun, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Robust, active tumor-targeting and fast bioresponsive anticancer nanotherapeutics based on natural endogenous materials, Acta Biomaterialia 2016, 45, 223-233.

6. Y.N. Zhong, J. Zhang, R. Cheng*, C. Deng, F.H. Meng, F. Xie*, and Z.Y. Zhong*, Reversibly Crosslinked Hyaluronic Acid Nanoparticles for Active Targeting and Intelligent Delivery of Doxorubicin to Drug Resistant CD44+ Human Breast Tumor Xenografts, J. Control. Release 2015, 205, 144-154.