Functional biodegradable polymers
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Biodegradable polymers such as polyesters, polycarbonates and polypeptides are among the most important synthetic biomaterials that are widely used in different biomedical fields such as tissue engineering and drug delivery. However, current biodegradable polymers e.g. polylactide (PLA) and poly(trimethylene carbonate) (PTMC) due to their lack of function often can’t meet the requirements of a particular biomedical application. Based on the needs of drug delivery systems, we have recently designed and synthesized a range of novel functional cyclic carbonate monomers (e.g. containing pendant dithiolane, pyridine disulfide, acrylate, vinyl sulfone and acetal groups), from which we have obtained varying functional biodegradable polymers and nanocarriers. Moreover, we have also designed and prepared a series of functional polypeptides and polypeptide-based nanocarriers through either innovative monomer design or postpolymerization modification.

 

Representative Papers

1. X.X. Wang, J. Zhang, R. Cheng*, F.H. Meng, C. Deng, and Z.Y. Zhong*, Facile synthesis of reductively degradable biopolymers using cystamine diisocyanate as a coupling agent, Biomacromolecules 2016, 17, 882-890.

2. J.T. Wu, J. Zhang, C. Deng*, F.H. Meng, and Z.Y. Zhong*, Vitamin E-Oligo(methyl diglycol L-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles, Biomacromolecules 2016, 17, 2367-2374.

3. Y. Zou, H. Meng, F.H. Meng*, C. Deng, J. Zhang, and Z.Y. Zhong*, Self-crosslinkable and intracellularly decrosslinkable biodegradable micellar nanoparticles: a robust, simple and multifunctional nanoplatform for high-efficiency targeted cancer chemotherapy, J. Control. Release 2016, 244, 326-335.

4. H.L. Sun, R. Cheng, C. Deng, F.H. Meng*, A.A. Dias, M. Hendriks, J. Feijen, and Z.Y. Zhong*, Enzymatically and Reductively Degradable a-Amino Acid-Based Poly(ester amide)s: Synthesis, Cell Compatibility, and Intracellular Anticancer Drug Delivery, Biomacromolecules 2015, 16, 597-605.

5. W. Chen, F.H. Meng, R. Cheng, C. Deng, J. Feijen*, and Z.Y. Zhong*, Advanced Drug and Gene Delivery Systems Based on Functional Biodegradable Polycarbonates and Copolymers, J. Control. Release 2014, 190, 398-414.

6. C. Deng, J.T. Wu, R. Cheng, F.H. Meng, H.A. Klok, and Z.Y. Zhong*, Functional Polypeptide and Hybrid Materials: Precision Synthesis via α-Amino Acid N-Carboxyanhydride Polymerization and Emerging Biomedical Applications, Prog. Polym. Sci. 2014, 39, 330-364. 

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