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Zhiyuan Zhong

Zhiyuan Zhong is a Distinguished Professor and Chair of Soochow University Biomedical Polymers Laboratory, and an Associate Editor of Biomacromolecules (ACS). He received his Ph.D. in 2002 from the University of Twente (The Netherlands). In 2011-2012, he worked as a Vice President of Suzhou BioBay (a top Biomedical Park in China).

His research focuses on biomedical polymers, nanomedicine and targeted cancer therapy. He has co-authored more than 180 papers with 12000 times of citation and an H-Index of 60. He is currently on the Editorial/Advisory Board of Materials Today, Journal of Controlled Release, Biomacromolecules, Journal of Materials Chemistry B, Nanotechnology, Nano Futures, Journal of Gene Medicine, Journal of Biomaterials Science Polymer Edition, and Materials Today Chemistry. He is a Chairman for the 1st, 2nd, 3rd and 4th Symposium on Innovative Polymers for Controlled Delivery (SIPCD 2010, 2012, 2014 and 2016) in Suzhou, China.

He has received several prestigious awards, including 2014 Biomacromolecules/Macromolecules Young Investigator Award from the American Chemical Society (ACS, San Francisco), the Bessel Research Award from the Humboldt Foundation (2013, Berlin), Award for Breakthrough Technologies in Drug Delivery Systems in Asia from the Japanese Society of Drug Delivery System and Controlled Release Society (2013, Hawaii), Jiangsu Specially-Appointed Professor (2013), Award for Top 10 Most Charming Scientist in Suzhou City (2013), and the National Outstanding Young Scholar Award (NSFC, 2012). 

Representative Papers 

1. Y. Zou, Y.H. Wei, G.L. Wang, F.H. Meng*, M.Y. Gao, G. Storm, and Z.Y. Zhong*, Nano-Polymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo, Adv. Mater. 2017, 29, 1603997 (DOI: 10.1002/adma.201603997)

2. J.T. Wu, C. Deng*, F.H. Meng, J. Zhang, H.L. Sun, and Z.Y. Zhong*, Hyaluronic acid coated PLGA nanoparticulate docetaxel effectively targets and suppresses orthotopic human lung cancer, J. Control. Release 2017,

3. P. Zhong, H. Meng, J. Qiu, J. Zhang, H.L. Sun, R. Cheng*, and Z.Y. Zhong*,αvβ3 Integrin-Targeted Reduction-Sensitive Micellar Mertansine Prodrug: Superb Drug Loading, Enhanced Stability, and Effective Inhibition of Melanoma Growth In Vivo, J. Control. Release 2017,  DOI: 10.1016/j.jconrel.2016.12.011

4. N. Zhang, Y.F. Xia, Y. Zou, W.J. Yang, J. Zhang, Z.Y. Zhong*, and F.H. Meng*, ATN-161 Peptide Functionalized Reversibly Crosslinked Polymersomes Mediate Targeted Doxorubicin Delivery into Melanoma-Bearing C57BL/6 Mice, Mol. Pharm. 2017, DOI: 10.1021/acs.molpharmaceut.6b00800

5. Y. Fang, Y. Jiang, Y. Zou, F.H. Meng*, J. Zhang, C. Deng, H.L. Sun and Z.Y. Zhong*, Targeted glioma chemotherapy by cyclic RGD peptide-functionalized reversibly core-crosslinked multifunctional poly(ethylene glycol)-b-poly(e-caprolactone) micelles, Acta Biomaterialia 2017, 50, 396–406.

6. Y.Q. Zhu, X.X. Wang, J. Zhang, F.H. Meng, C. Deng, R. Cheng, J. Feijen*, and Z.Y. Zhong*, Exogenous vitamin C boosts the antitumor efficacy of paclitaxel containing reduction-sensitive shell-sheddable micelles in vivo, J. Control. Release 2017, 250, 9-19.

7. J.T. Wu, J. Zhang, C. Deng*, F.H. Meng, R. Cheng, and Z.Y. Zhong*, Robust, Responsive and Targeted PLGA Anticancer Nanomedicines by Combining Reductively Cleavable Surfactant and Covalent Hyaluronic Acid Coating, ACS Appl. Mater. Interfaces 2017, 9, 3985-3994.

8. W. Chen, Y. Zou, Z.Y. Zhong*, and R. Haag *, Cyclo(RGD)-decorated Redox-responsive Nanogels Mediate Targeted Chemotherapy of Integrin Over-expressing Human Glioblastoma In Vivo, Small 2017, 13, 1601997.

9. J. Chen, Y. Zou, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Multifunctional Click Hyaluronic Acid Nanogels for Targeted Protein Delivery and Effective Cancer Treatment In Vivo, Chem. Mater. 2016, 28, 8792-8799.

10. P. Zhong, J. Zhang, C. Deng, R. Cheng*, F.H. Meng, and Z.Y. Zhong*, Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy, Biomacromolecules 2016, 17, 3602-3608.

11. Y.N. Zhong, M. Dimde, D. Stöbener, F.H. Meng*, C. Deng, Z.Y. Zhong*, and R. Haag, Micelles with Sheddable Dendritic Polyglycerol Sulfate Shells Show Extraordinary Tumor Targetability and Chemotherapy In Vivo, ACS Appl. Mater. Interfaces 2016, 8, 27530-27538.

12. W.J. Yang, Y. Zou, F.H. Meng*, J. Zhang, R. Cheng, C. Deng, and Z.Y. Zhong*, Efficient and targeted suppression of human lung tumor xenografts in mice with methotrexate sodium encapsulated in all-function-in-one chimaeric polymersomes, Adv. Mater. 2016, 28, 8234-8239.

13. Y.Q. Zhu, X.X. Wang, J. Chen, J. Zhang, F.H. Meng, C. Deng, R. Cheng, J. Feijen*, and Z.Y. Zhong*, Bioresponsive and fluorescent hyaluronic acid-iodixanol nanogels for targeted X-ray computed tomography imaging and chemotherapy of breast tumors, J. Control. Release 2016, 244, 229-239.

14. Y. Zou, F.H. Meng*, C. Deng, and Z.Y. Zhong*, Robust, tumor-homing and redox-sensitive polymersomal doxorubicin: A superior alternative to Doxil and Caelyx? J. Control. Release 2016, 239, 149-158.

15. S. Li, J. Zhang, C. Deng*, F.H. Meng, L. Yu, and Z.Y. Zhong*, Redox-sensitive and intrinsically fluorescent photoclick hyaluronic acid nanogels for traceable and targeted delivery of cytochrome C to breast tumor in mice, ACS Appl. Mater. Interfaces 2016, 8, 21155-21162

16. B.F. Sun, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Robust, active tumor-targeting and fast bioresponsive anticancer nanotherapeutics based on natural endogenous materials, Acta Biomaterialia 2016, 45, 223-233.

17. J.T. Wu, J. Zhang, C. Deng*, F.H. Meng, and Z.Y. Zhong*, Vitamin E-Oligo(methyl diglycol L-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles, Biomacromolecules 2016, 17, 2367-2374

18. Y. Zou, H. Meng, F.H. Meng*, C. Deng, J. Zhang, and Z.Y. Zhong*, Self-crosslinkable and intracellularly decrosslinkable biodegradable micellar nanoparticles: a robust, simple and multifunctional nanoplatform for high-efficiency targeted cancer chemotherapy, J. Control. Release 2016, 244, 326-335.

19. Y.Q. Zhu, J. Zhang*, F.H. Meng, C. Deng, R. Cheng, J. Feijen*, and Z.Y. Zhong*, cRGD-functionalized reduction-sensitive shell-sheddable biodegradable micelles mediate enhanced doxorubicin delivery to human glioma xenografts in vivo, J. Control. Release 2016, 233, 29-38.

20. X.X. Wang, J. Zhang, R. Cheng*, F.H. Meng, C. Deng, and Z.Y. Zhong*, Facile synthesis of reductively degradable biopolymers using cystamine diisocyanate as a coupling agent, Biomacromolecules 2016, 17, 882-890.

21. Y.N. Zhong, K. Goltsche, L. Cheng, F. Xie, F.H. Meng*, C. Deng, Z.Y. Zhong*, and R. Haag, Hyaluronic acid-shelled acid-activatable paclitaxel prodrug micelles effectively target and treat CD44-overexpressing human breast tumor xenografts in vivo, Biomaterials 2016, 84, 250-261.

22. X. Li, W.J. Yang, Y. Zou, F.H. Meng*, C. Deng, and Z.Y. Zhong*, Efficacious delivery of protein drugs to prostate cancer cells by PSMA-targeted pH-responsive chimaeric polymersomes, J. Control. Release 2015, 220, 704-714.

23. R. Cheng, F.H. Meng, C. Deng, and Z.Y. Zhong*, Bioresponsive Polymeric Nanotherapeutics for Targeted Cancer Chemotherapy, Nano Today 2015, 10, 656-670.