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Huanli Sun

Dr. Huanli Sun is an associate professor at College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou,China. She obtained her B.S. and Ph.D degrees from Soochow University in 2008 and 2013, respectively, under the supervision of Prof. Zhiyuan Zhong. Afterwards, she worked as a postdoctoral research fellow with Prof. Frank Caruso at The University of Melbourne, Australia. She then joined the Biomedical Polymers Laboratory at Soochow University in Sep. 2015. She has published over 20 peer-reviewed papers with a total citation of >1,100. Her current research interests are developing multifunctional polymeric nanomedicines, and exploring monoclonal antibody and polysaccharide mediated active tumor chemotherapy.

Representative Papers

1.   H.L. Sun, J. Cui, Y. Ju, X. Chen, E.H.H. Wong, J. Tran, G.G. Qiao and F. Caruso, Tuning the Properties of Polymer Capsules for Cellular Interactions, Bioconjugate Chemistry, 2017, 28, 1859-1866.

2.  H.L. Sun, M. Bjornmalm, J.W. Cui, E.H.H. Wong, Y.L. Dai, Q. Dai, G.G. Qiao and F. Caruso, Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model, ACS Macro Letters, 2015, 4, 1205-1209.

3.  H.L. Sun, E.H.H. Wong, Y. Yan, J. Cui, Q. Dai, J. Guo, G.G. Qiao and F. Caruso, The Role of Capsule Stiffness on Cellular Processing, Chemical Science, 2015, 6, 3505-3514.

4.   H.L. Sun, R. Cheng, C. Deng, F. Meng, A.A. Dias, M. Hendriks, J. Feijen and Z. Zhong, Enzymatically and Reductively Degradable α-Amino Acid-Based Poly(Ester Amide)S: Synthesis, Cell Compatibility, and Intracellular Anticancer Drug Delivery, Biomacromolecules, 2015, 16, 597-605.

5.   H.L. Sun, F. Meng, R. Cheng, C. Deng and Z. Zhong, Reduction-Responsive Polymeric Micelles and Vesicles for Triggered Intracellular Drug Release, Antioxidant and Redox Signaling, 2014, 21, 755-767.

6. H.L. Sun, F. Meng, R. Cheng, C. Deng and Z. Zhong, Reduction and pH Dual-Bioresponsive Crosslinked Polymersomes for Efficient Intracellular Delivery of Proteins and Potent Induction of Cancer Cell Apoptosis, Acta Biomaterialia, 2014, 10, 2159-2168.

7. H.L. Sun, F.H. Meng, R. Cheng, C. Deng and Z.Y. Zhong, Reduction-Sensitive Degradable Micellar Nanoparticles as Smart and Intuitive Delivery Systems for Cancer Chemotherapy, Expert Opinion on Drug Delivery, 2013, 10, 1109-1122.

8.   H.L. Sun, F.H. Meng, R. Cheng, C. Deng and Z.Y. Zhong, Reversibly Crosslinked pH-Sensitive Polymersomes for Efficient Intracellular Protein Delivery, Journal of Controlled Release, 2013, 172, E104-E104.

9.   W. Wang, H.L. Sun co-first author, F.H. Meng, S.B. Ma, H.Y. Liu and Z.Y. Zhong, Precise Control of Intracellular Drug Release and Anti-Tumor Activity of Biodegradable Micellar Drugs via Reduction-Sensitive Shell-Shedding, Soft Matter, 2012, 8, 3949-3956.

10. H.L. Sun, B.N. Guo, R. Cheng, F.H. Meng, H.Y. Liu and Z.Y. Zhong, Reduction-Responsive Shell-Sheddable Biodegradable Micelles for Intracellular Doxorubicin Delivery, Journal of Controlled Release, 2011, 152, E84-E85.

11. H.L. Sun, F. Meng, A.A. Dias, M. Hendriks, J. Feijen and Z. Zhong, α-Amino Acid Containing Degradable Polymers as Functional Biomaterials: Rational Design, Synthetic Pathway, and Biomedical Applications, Biomacromolecules, 2011, 12, 1937-1955.

12. H.L. Sun, B. Guo, X. Li, R. Cheng, F. Meng, H. Liu and Z. Zhong, Shell-Sheddable Micelles Based on Dextran-SS-Poly(ε-Caprolactone) Diblock Copolymer for Efficient Intracellular Release of Doxorubicin, Biomacromolecules, 2010, 11, 848-854.

13. H.L. Sun, B. Guo, R. Cheng, F. Meng, H. Liu and Z. Zhong, Biodegradable Micelles with Sheddable Poly(Ethylene Glycol) Shells for Triggered Intracellular Release of Doxorubicin, Biomaterials, 2009, 30, 6358-6366.

14. D. Song, J. Cui, H.L. Sun, T.-H. Nguyen, S. Alcantara, R. De Rose, S.J. Kent, C.J.H. Porter and F. Caruso, Templated Polymer Replica Nanoparticles to Facilitate Assessment of Material-Dependent Pharmacokinetics and Biodistribution, ACS Applied Materials & Interfaces, 2017, 9, 33683-33694.

15. P. Zhong, M. Qiu, J. Zhang, H.L. Sun, R. Cheng, C. Deng, F. Meng and Z. Zhong, cRGD-Installed Docetaxel-Loaded Mertansine Prodrug Micelles: Redox-Triggered Ratiometric Dual Drug Release and Targeted Synergistic Treatment of B16f10 Melanoma, Nanotechnology, 2017, 28, 295103.

16. P. Zhong, H. Meng, J. Qiu, J. Zhang, H.L. Sun, R. Cheng and Z. Zhong, αvβ3 Integrin-Targeted Reduction-Sensitive Micellar Mertansine Prodrug: Superb Drug Loading, Enhanced Stability, and Effective Inhibition of Melanoma Growth in Vivo, Journal of Controlled Release, 2017, 259, 176-186.

17. J. Wu, C. Deng, F. Meng, J. Zhang, H.L. Sun and Z. Zhong, Hyaluronic Acid Coated PLGA Nanoparticulate Docetaxel Effectively Targets and Suppresses Orthotopic Human Lung Cancer, Journal of Controlled Release, 2017, 259, 76-82.

18. M. Qiu, J. Ouyang, H.L. Sun, F. Meng, R. Cheng, J. Zhang, L. Cheng, Q. Lan, C. Deng and Z. Zhong, Biodegradable Micelles Based on Poly(Ethylene Glycol)-b-Polylipopeptide Copolymer: A Robust and Versatile Nanoplatform for Anticancer Drug Delivery, ACS Applied Materials & Interfaces, 2017, 9, 27587-27595.

19. J. Qiu, R. Cheng, J. Zhang, H.L. Sun, C. Deng, F. Meng and Z. Zhong, Glutathione-Sensitive Hyaluronic Acid-Mercaptopurine Prodrug Linked via Carbonyl Vinyl Sulfide: A Robust and CD44-Targeted Nanomedicine for Leukemia, Biomacromolecules, 2017, 18, 3207-3214.

20. Y. Fang, Y. Jiang, Y. Zou, F. Meng, J. Zhang, C. Deng, H.L. Sun and Z. Zhong, Targeted Glioma Chemotherapy by Cyclic Rgd Peptide-Functionalized Reversibly Core-Crosslinked Multifunctional Poly(Ethylene Glycol)-b-Poly(ε-Caprolactone) Micelles, Acta Biomaterialia, 2017, 50, 396-406.

21. Y. Ju, J.W. Cui, H.L. Sun, M. Mullner, Y.L. Dai, J.L. Guo, N. Bertleff-Zieschang, T. Suma, J.J. Richardson and F. Caruso, Engineered Metal-Phenolic Capsules Show Tunable Targeted Delivery to Cancer Cells, Biomacromolecules, 2016, 17, 2268-2276.

22. X. Chen, J.W. Cui, H.L. Sun, M. Mullner, Y. Yan, K.F. Noi, Y. Ping and F. Caruso, Analysing Intracellular Deformation of Polymer Capsules Using Structured Illumination Microscopy, Nanoscale, 2016, 8, 11924-11931.

23. Y. Ping, J.L. Guo, H. Ejima, X. Chen, J.J. Richardson, H.L. Sun and F. Caruso, pH-Responsive Capsules Engineered from Metal-Phenolic Networks for Anticancer Drug Delivery, Small, 2015, 11, 2032-2036.

24. J. Lv, H.L. Sun, Y. Zou, F. Meng, A.A. Dias, M. Hendriks, J. Feijen and Z. Zhong, Reductively Degradable Alpha-Amino Acid-Based Poly(Ester Amide)-Graft-Galactose Copolymers: Facile Synthesis, Self-Assembly, and Hepatoma-Targeting Doxorubicin Delivery, Biomaterials Science, 2015, 3, 1134-1146.

25. J.L. Guo, H.L. Sun, K. Alt, B.L. Tardy, J.J. Richardson, T. Suma, H. Ejima, J.W. Cui, C.E. Hagemeyer and F. Caruso, Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and Cis-Diols, Advanced Healthcare Materials, 2015, 4, 1796-1801.

26. Q. Dai, Y. Yan, J.L. Guo, M. Bjornmalm, J.W. Cui, H.L. Sun and F. Caruso, Targeting Ability of Affibody-Functionalized Particles Is Enhanced by Albumin but Inhibited by Serum Coronas, ACS Macro Letters, 2015, 4, 1259-1263.

27. Y.N. Zhong, W.J. Yang, H.L. Sun, R. Cheng, F.H. Meng, C. Deng and Z.Y. Zhong, Ligand-Directed Reduction-Sensitive Shell-Sheddable Biodegradable Micelles Actively Deliver Doxorubicin into the Nuclei of Target Cancer Cells, Biomacromolecules, 2013, 14, 3723-3730.

28. X.Y. Wang, H.L. Sun, F.H. Meng, R. Cheng, C. Deng and Z.Y. Zhong, Galactose-Decorated Reduction-Sensitive Degradable Chimaeric Polymersomes as a Multifunctional Nanocarrier to Efficiently Chaperone Apoptotic Proteins into Hepatoma Cells, Biomacromolecules, 2013, 14, 2873-2882.

 

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