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Jian Zhang

Jian Zhang, Ph.D., is currently an Associate Professor of Soochow University. He obtained his Ph.D. degree in Pharmaceutical Sciences of Microbiology and Biochemistry in June 2010 from China Pharmaceutical University under the supervision of Prof. Dr. Yueqing Gu. After that, he joined Prof. Dr. Victor C. Yang lab as a post-doctoral fellow from 2010-2013. In 2014, he joined Soochow University Biomedical Polymers Lab as Associate Professor. He has published over 40 peer-reviewed articles. His current research focus is to design “smart” biodegradable nano-scale systems for malignant brain tumor targeted therapy.

Representative Papers

1. Wu J, Zhang J, Deng C, Meng F, Cheng R, Zhong Z, Robust, Responsive and Targeted PLGA Anticancer Nanomedicines by Combining Reductively Cleavable Surfactant and Covalent Hyaluronic Acid Coating, ACS Applied Materials & Interfaces 2017, DOI: 10.1021/acsami.6b15105.

2. Zhu Y, Zhang J*, Meng F, Deng C, Cheng R, Feijen J, et al. cRGD-functionalized reduction-sensitive shell-sheddable biodegradable micelles mediate enhanced doxorubicin delivery to human glioma xenografts in vivo. Journal of Controlled Release 2016;233:29-38.

3. Zhong P, Zhang J, Deng C, Cheng R, Meng F, Zhong Z. Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy. Biomacromolecules 2016, in press.

4. Wu J, Zhang J, Deng C, Meng F, Zhong Z. Vitamin E-Oligo(methyl diglycol l-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles. Biomacromolecules 2016;17:2367-74.

5. Wang X, Zhang J, Cheng R, Meng F, Deng C, Zhong Z. Facile Synthesis of Reductively Degradable Biopolymers Using Cystamine Diisocyanate as a Coupling Agent. Biomacromolecules 2016;17:882-90.

6. Li S, Zhang J, Deng C, Meng F, Yu L, Zhong Z. Redox-Sensitive and Intrinsically Fluorescent Photoclick Hyaluronic Acid Nanogels for Traceable and Targeted Delivery of Cytochrome c to Breast Tumor in Mice. ACS Applied Materials & Interfaces 2016;8:21155-62.

7. Zhong Y, Zhang J, Cheng R, Deng C, Meng F, Xie F, et al. Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+ human breast tumor xenografts. Journal of Controlled Release 2015;205:144-54.

8. Shin MC, Zhang J, Min KA, He H, David AE, Huang Y, et al. PTD-Modified ATTEMPTS for Enhanced Toxin-based Cancer Therapy: An In Vivo Proof-of-Concept Study. Pharmaceutical Research 2015;32:2690-703.

9. Zhou J, Zhang J (co-first author), Gao W. Enhanced and selective delivery of enzyme therapy to 9L-glioma tumor via magnetic targeting of PEG-modified, beta-glucosidase-conjugated iron oxide nanoparticles. International Journal of Nanomedicine 2014;9:2905-17.

10. Zhang J, Shin MC, Yang VC. Magnetic targeting of novel heparinized iron oxide nanoparticles evaluated in a 9L-glioma mouse model. Pharmaceutical Research 2014;31:579-92.

11. Shin MC, Zhang J (co-first author), Min KA, Lee K, Moon C, Balthasar JP, et al. Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer therapy. Journal of Controlled Release 2014;194:197-210.

12. Shin MC, Zhang J (co-first author), Min KA, Lee K, Byun Y, David AE, et al. Cell-penetrating peptides: achievements and challenges in application for cancer treatment. Journal of Biomedical Materials Research Part A 2014;102:575-87.

13. Zhou J, Zhang J (co-first author), David AE, Yang VC. Magnetic tumor targeting of beta-glucosidase immobilized iron oxide nanoparticles. Nanotechnology 2013;24:375102.

14. Zhang J, Shin MC, David AE, Zhou J, Lee K, He H, et al. Long-circulating heparin-functionalized magnetic nanoparticles for potential application as a protein drug delivery platform. Molecular Pharmaceutics 2013;10:3892-902.

15. Shin MC, Zhang J, David AE, Trommer WE, Kwon YM, Min KA, et al. Chemically and biologically synthesized CPP-modified gelonin for enhanced anti-tumor activity. Journal of Controlled Release 2013;172:169-78.

16. Zhang J, Deng D, Zhu H, Byun Y, Yang VC, Gu Y. Folate-conjugated thermo-responsive micelles for tumor targeting. Journal of Biomedical Materials Research Part A 2012;100:3134-42.

17. Zhang J, Deng D, Qian Z, Liu F, Chen X, An L, et al. The targeting behavior of folate-nanohydrogel evaluated by near infrared imaging system in tumor-bearing mouse model. Pharmaceutical Research 2010;27:46-55.

18. Zhang J, Qian Z, Gu Y. In vivo anti-tumor efficacy of docetaxel-loaded thermally responsive nanohydrogel. Nanotechnology 2009;20:325102.

19. Zhang J, Chen H, Xu L, Gu Y. The targeted behavior of thermally responsive nanohydrogel evaluated by NIR system in mouse model. Journal of Controlled Release 2008;131:34-40.

20. Chen H, Zhang J, Qian Z, Liu F, Chen X, Hu Y, et al. In vivo non-invasive optical imaging of temperature-sensitive co-polymeric nanohydrogel. Nanotechnology 2008;19:185707.