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Ru Cheng

Dr. Ru Cheng is currently an Associate Professor of Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science Soochow University. She obtained PhD degree in Chemical Engineering in 2006 from Nanjing University of Technology under the supervision of Prof. Jun Shi and Prof. Pei Huang. After that she worked as a Postdoctor in Institute of Soil Science, Chinese Academy of Sciences under the supervision of Prof. Jianmin Zhou (2006-2007). In 2007 she joined the faculty at Soochow University as Lecture. In 2012 she was promoted to an Associate Professor. She has published over 60 peer-reviewed articles (citation > 3700, H index: 31), 8 Chinese Patents and 2 book chapters. Her current main research interests include stimuli-responsive micelles and prodrugs, functional polyurethane, reduction-sensitive polymers.

Representative Papers

1. R. Cheng, F. Feng, F. Meng, C. Deng, J. Feijen, Z. Zhong, Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. J. Control. Release. 152 (2011) 2-12.

2. R. Cheng, F. Meng, S. Ma, H. Xu, H. Liu, X. Jing, et al., Reduction and temperature dual-responsive crosslinked polymersomes for targeted intracellular protein delivery. J. Mater. Chem. 21 (2011) 19013-19020.

3. R. Cheng, X. Wang, W. Chen, F. Meng, C. Deng, H. Liu, et al., Biodegradable poly(epsilon-caprolactone)-g-poly(2-hydroxyethyl methacrylate) graft copolymer micelles as superior nano-carriers for "smart" doxorubicin release. J. Mater. Chem. 22 (2012) 11730-11738.

4. R. Cheng, F. Meng, C. Deng, H.-A. Klok, Z. Zhong, Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery. Biomaterials. 34 (2013) 3647-3657.

5. R. Cheng, F. Meng, C. Deng, Z. Zhong, Bioresponsive polymeric nanotherapeutics for targeted cancer chemotherapy. Nano Today. 10 (2015) 656-670.

6. F. Huang, R. Cheng*, F. Meng, C. Deng, Z. Zhong*, Micelles Based on Acid Degradable Poly(acetal urethane): Preparation, pH-Sensitivity, and Triggered Intracellular Drug Release. Biomacromolecules. 16 (2015) 2228-2236.

7. W. Lu, X. Wang, R. Cheng*, C. Deng, F. Meng, Z. Zhong*, Biocompatible and bioreducible micelles fabricated from novel alpha-amino acid-based poly(disulfide urethane)s: design, synthesis and triggered doxorubicin release. Polym. Chem. 6 (2015) 6001-6010.

8. Y. Zhong, J. Zhang, R. Cheng*, C. Deng, F. Meng, F. Xie*, et al., Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+human breast tumor xenografts. J. Control. Release. 205 (2015) 144-154.

9. X. Wang, J. Zhang, R. Cheng*, F. Meng, C. Deng, Z. Zhong*, Facile Synthesis of Reductively Degradable Biopolymers Using Cystamine Diisocyanate as a Coupling Agent. Biomacromolecules. 17 (2016) 882-890.

10. P. Zhong, J. Zhang, C. Deng, R. Cheng*, F. Meng, Z. Zhong*, Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy. Biomacromolecules. 17 (2016) 3602-3608. 

11. P. Zhong, H. Meng, J. Qiu, J. Zhang, H. Sun, R. Cheng*, et al., αvβ3 Integrin-targeted reduction-sensitive micellar mertansine prodrug: Superb drug loading, enhanced stability, and effective inhibition of melanoma growth in vivo. J. Control. Release. 259 (2017) 176-186.

12. P. Zhong, M. Qiu, J. Zhang, H. Sun, R. Cheng*, C. Deng, F. Meng, Z. Zhong*, cRGD-installed docetaxel-loaded mertansine prodrug micelles: redox-triggered ratiometric dual drug release and targeted synergistic treatment of B16F10 melanoma. Nanotechnology. 28 (2017) 295103.

13. K. Wu, R. Cheng*, J. Zhang, F. Meng, C. Deng, Z. Zhong*, Micellar nanoformulation of lipophilized bortezomib: high drug loading, improved tolerability and targeted treatment of triple negative breast cancer. J. Mater. Chem. B. 5 (2017) 5658-5667.

14. J. Qiu, R. Cheng*, J. Zhang, H. Sun, C. Deng, F. Meng, Z. Zhong*, Glutathione-Sensitive Hyaluronic Acid-Mercaptopurine Prodrug Linked via Carbonyl Vinyl Sulfide: A Robust and CD44-Targeted Nanomedicine for Leukemia. Biomacromolecules. Doi:10.1021/acs.biomac.7b00846 (2017).

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