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Fenghua Meng

Prof. Dr. Fenghua Meng is currently a Professor of Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science Soochow University. She obtained PhD degree in Polymer Chemistry and Biomaterials in 2003 from University of Twente (theNetherlands) under the supervision of Prof. Jan Feijen. After that she continued with a two-year postdoctoral experience (2005-2007). In 2007 she joined the faculty at Soochow University as Associate professor. In 2010 she was promoted to a full Professor. She has published over 100 peer-reviewed articles (citation > 8200, H index: 49) and several book chapters, among which 18 was selected as highly-cited articles by Web of Science. She has applied > 40 domestic and foreign patents (11 patents have been successfully transferred to a local pharmaceutical company). Her current main research interests include biodegradable nanomedicines, stimuli-responsive micelles and polymersomes, controlled and targeted anticancer drug and protein delivery.

Representative Papers 

1.         Y. Zou, M. Zheng, W.J. Yang, F.H. Meng*, K. Miyata, H.J. Kim, K. Kataoka*, Z.Y. Zhong*, Virus-Mimicking Chimaeric Polymersomes Boost Targeted Cancer siRNA Therapy In Vivo, Adv. Mater. 2017, http://dx.doi.org/10.1002/adma.201703285.

2.         Y. Zou, Y.H. Wei, G.L. Wang, F.H. Meng*, M.Y. Gao, G. Storm, and Z.Y. Zhong*, Nanopolymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo, Adv. Mater. 2017, http://dx.doi.org/10.1002/adma.201603997

3.         W.J. Yang, Y. Fang, Y. F. Xia, F.H. Meng*, J. Zhang, Z.Y. Zhong*, Selective cell penetrating peptide-functionalized polymersomes mediate efficient and targeted delivery of methotrexate disodium to human lung cancer in vivo, Adv. Healthcare Mater. 2017, in press.

4.         W.J. Yang, Y.F. Xia, Y. Zou, F.H. Meng*, J. Zhang, Z.Y. Zhong*, Bioresponsive chimaeric nano-polymersomes enable targeted and efficacious protein therapy for human lung cancers in vivo, Chem. Mate., 2017, DOI: 10.1021/acs.chemmater.7b02953.

5.         Y. Fang, W.J. Yang, Y.F. Zhang, L. Cheng, F.H. Meng*, Z.Y. Zhong*, GE11 peptide directed robust polymersomal nanomedicines for orthotopic liver cancer therapy, Acta Biomaterialia 2017, DOI:10.1016/j.actbio.2017.10.013.

6.         Y. Fang, Y. Jiang, Y. Zou, F.H. Meng*, J. Zhang, C. Deng, H.L. Sun and Z.Y. Zhong*, Targeted glioma chemotherapy by cyclic RGD peptide-functionalized reversibly core-crosslinked multifunctional poly(ethylene glycol)-b-poly(e-caprolactone) micelles, Acta Biomaterialia 2017, 50,396-406

7.         Y.N. Zhong; F.H. Meng*, C. Deng, X.L. Mal, Z.Y. Zhong*, Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles. Drug delivery; 2017, 24, 1482-1490.

8.         H. Meng, Y. Zou, P. Zhong, F.H. Meng*, J. Zhang, R. Cheng, and Z.Y. Zhong*, A Smart Nano-Prodrug Platform with Reactive Drug Loading, Superb Stability and Fast Responsive Drug Release for Targeted Cancer Therapy, Macromol. Biosci. 2017, 17 (10) 1600518. http://dx.doi.org/10.1002/mabi.201600518 (invited article).

9.         N. Zhang, Y.F. Xia, Y. Zou, W.J. Yang, J. Zhang, Z.Y. Zhong*, and F.H. Meng*, ATN-161 Peptide Functionalized Reversibly Crosslinked Polymersomes Mediate Targeted Doxorubicin Delivery into Melanoma-Bearing C57BL/6 Mice, Mol. Pharm. 2017, 14, 2538-2547 (invited article).

10.     C.F. Hang#, Y. Zou#, Y.N. Zhong, Z.Y. Zhong*, F.H. Meng*, NIR and UV-Responsive Degradable Hyaluronic Acid Nanogels for CD44-Targeted and Remotely Triggered Intracellular Doxorubicin Delivery, Colloids Surf. B: Biointerfaces 2017, 158, 547-555.

11.     Y. Zou, Y. Fang, H. Meng, F.H. Meng*, C. Deng, J. Zhang and Z.Y. Zhong*, Self-Crosslinkable and Intracellularly Decrosslinkable Biodegradable Micelles: A Robust, Simple and Multifunctional Nanoplatform for High-Efficiency Targeted Cancer Chemotherapy, J. Control. Release 2016, 244, 326-335.

12.     Y.N. Zhong, M. Dimde, D. Stöbener, F.H. Meng*, C. Deng, Z.Y. Zhong*, and R. Haag, Micelles with Sheddable Dendritic Polyglycerol Sulfate Shells Show Extraordinary Tumor Targetability and Chemotherapy In Vivo, ACS Appl. Mater. Interfaces 2016, 8, 27530-27538.

13.     W.J. Yang, Y. Zou, F.H. Meng*, J. Zhang, R. Cheng, C. Deng, and Z.Y. Zhong*, Efficient and targeted suppression of human lung tumor xenografts in mice with methotrexate sodium encapsulated in all-function-in-one chimaeric polymersomes, Adv. Mater. 2016, 28 (37), 8234-8239.

14.     Y.N. Zhong, K. Goltsche, L. Cheng, F. Xie, F.H. Meng*, C. Deng, Z.Y. Zhong*, and R. Haag, Hyaluronic acid-shelled acid-activatable paclitaxel prodrug micelles effectively target and treat CD44-overexpressing human breast tumor xenografts in vivo, Biomaterials 2016, 84, 250-261.

15.     Y. Zou, F.H. Meng*, C. Deng, and Z.Y. Zhong*, Robust, Tumor-Homing and Redox-Sensitive Polymersomal Doxorubicin: A Superior Alternative to Doxil and Caelyx? J. Control. Release 2016, 239, 149-158.

16.     X. Li, W.J. Yang, Y. Zou, F.H. Meng*, C. Deng, and Z.Y. Zhong*, Efficacious delivery of protein drugs to prostate cancer cells by PSMA-targeted pH-responsive chimaeric polymersomes, J. Control. Release 2015, 220, 704-714.

17.     L. Lu, Y. Zou, W.J. Yang, F.H. Meng*, C. Deng, R. Cheng, and Z.Y. Zhong*, Anisamide-Decorated pH-Sensitive Degradable Chimaeric Polymersomes Mediate Potent and Targeted Protein Delivery to Lung Cancer Cells, Biomacromolecules 2015, 16(6), 1726-1735. 

18.     J.L. Lv, H.L. Sun, Y. Zou, F.H. Meng*, A.A. Dias, M. Hendriks, J. Feijen and Z.Y. Zhong*, Reduction degradable amino acid-based poly-(ester amide)-graft-galactose copolymers: facile synthesis, self-assembly, and hepatoma targeting doxorubicin delivery. Biomaterials Science, 2015, 3, 1134-1146.

19.     H.L. Sun, R. Cheng, C. Deng, F.H. Meng*, A.A. Dias, M. Hendriks, J. Feijen, and Z.Y. Zhong*, Enzymatically and Reductively Degradable a-Amino Acid-Based Poly(ester amide)s: Synthesis, Cell Compatibility, and Intracellular Anticancer Drug Delivery, Biomacromolecules 2015, 16, 597-605.

20.     Y.N. Zhong, C. Wang, R. Cheng, L. Cheng, F.H. Meng*, Z. Liu*, Z.Y. Zhong*, and R. Haag, cRGD-Directed, NIR-Responsive and Robust AuNR/PEG-PCL Hybrid Nanoparticles for Targeted Chemotherapy of Glioblastoma In Vivo, J. Control. Release 2014, 195, 63-71.

21.     Y. Zou, Y. Song, W.J. Yang, F.H. Meng*, H. Y. Liu, and Z.Y. Zhong*, Galactose-Installed Photo-Crosslinked pH-Sensitive Degradable Micelles for Active Targeting Chemotherapy of Hepatocellular Carcinoma in Mice, J. Control. Release 2014, 193, 154-161

22.     H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, Z.Y. Zhong*, Reduction-Responsive Polymeric Micelles and Vesicles for Triggered Intracellular Drug Release, Antioxidants & Redox Signaling 2014, 21, 755-767 (invited review)

23.     F.H. Meng, Y.N. Zhong, R. Cheng, C. Deng, Z.Y. Zhong*, pH-Sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: concept and recent advances, Nanomedicine, 2014, 9, 487-499 (invited review)

24.     H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, Z.Y. Zhong*, Reduction and pH dual-bioresponsive crosslinked polymersomes for efficient intracellular delivery of proteins and potent induction of cancer cell apoptosis. Acta Biomaterialia 2014, 10, 2159-2168

25.     X.Y. Wang, H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, Z.Y. Zhong*, Galactose-Decorated Reduction-Sensitive Degradable Chimaeric Polymersomes as a Multifunctional Nanocarrier to Efficiently Chaperone Apoptotic Proteins into Hepatoma Cells. Biomacromolecules, 2013, 14, 2873–2882

26.     Y.D. Gu, Y.N. Zhong, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Acetal-Linked Paclitaxel Prodrug Micellar Nanoparticles as a Versatile and Potent Platform for Cancer Therapy, Biomacromolecules, 2013, 14, 2772–2780

27.     H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, Z.Y. Zhong*, Reduction-sensitive degradable micellar nanoparticles as smart and intuitive delivery systems for cancer chemotherapy. Expert Opinion on Drug Delivery 2013, 10, 1109-1022. (invited review) (IF:4.869)

28.     W. Chen, P. Zhong, F.H. Meng*, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Redox and pH-Responsive Degradable Micelles for Dually Activated Intracellular Anticancer Drug Release, J. Control. Release 2013, 169, 171–179.

29.     F.H. Meng, R. Cheng, C. Deng, Z.Y. Zhong*, Intracellular Drug Release Nanosystems, Mater. Today 2012, 15, 436-442. (invited review) 

30.     Y.L. Wu, W. Chen, F.H. Meng*, Z.J. Wang, R. Cheng, C. Deng, H.Y. Liu, Z.Y. Zhong*, Core-crosslinked pH-sensitive degradable micelles: A promising approach to resolve the extracellular stability versus intracellular drug release dilemma, J. Controlled Release 2012 , 164,338-345.

31.     S.K. Li, F.H. Meng, Z.J. Wang, Y.N. Zhong, M. Zheng, H.Y. Liu, Z.Y. Zhong*, Biodegradable Polymersomes with an Ionizable Membrane: Facile Preparation, Superior Protein Loading and Endosomal pH-Responsive Protein Release, Eur. J. Pharm. Biopharm. 2012, 82, 103-111. (invited article)

32.     F.H. Meng, and Z.Y. Zhong*, Polymersomes Spanning from Nano to Micro Scales: Advanced Vehicles for Controlled Drug Delivery and Robust Vesicles for Virus and Cell-Mimicking, J. Phys. Chem. Letters 2011, 2, 1533-1539. (Invited Perspective)

33.     G.J. Liu, S.B. Ma, S.K. Li, R. Cheng, F.H. Meng*, H.Y. Liu, Z.Y. Zhong*, The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes, Biomaterials 2010, 31, 7575-7585.

34.     H.L. Sun, F.H. Meng*, B.N. Guo, X.Q. Li, R. Cheng, H.Y. Liu, and Z.Y. Zhong*, Shell-sheddable micelles based on dextran-ss-poly(e-caprolactone) diblock copolymer for efficient intracellular release of doxorubicin, Biomacromolecules 2010, 11, 848–854.

35.     W. Chen, F.H. Meng*, R. Cheng, and Z.Y. Zhong*, pH-Sensitive Degradable Polymersomes for Triggered Release of Anticancer Drugs: a Comparative Study with Micelles, J. Control. Release 2010, 142, 40-46.

36.     W. Chen, H.C. Yang, R. Wang, R. Cheng, F.H. Meng*, W.X. Wei, and Z.Y. Zhong*, Versatile Synthesis of Functional Biodegradable Polymers by Combining Ring-Opening Polymerization and Postpolymerization Modification via Michael-Type Addition Reaction, Macromolecules 2010, 43, 201–207. 

37.     C.H. Zhu, S.Y. Jung, G.Y. Si, R. Cheng, F.H. Meng*, X.L. Zhu, T.G. Park, and Z.Y. Zhong*, Cationic methacrylate copolymers containing primary and tertiary amino side groups: controlled synthesis via RAFT polymerization, DNA condensation, and in vitro gene transfection, J. Polym. Sci. Part A: Polym. Chem. 2010, 48, 2869–2877.

38.     Y.L. Li, L. Zhu, Z.Z. Liu, R. Cheng, F.H. Meng*, J.H. Cui, S.J. Ji, and Z.Y. Zhong*, Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells, Angew. Chem. Int. Ed. 2009, 48, 9914-9918.

39.     Y.M. Xu, F.H. Meng*, R. Cheng, Z.Y. Zhong*, Reduction-Sensitive Reversibly Crosslinked Biodegradable Micelles for Triggered Release of Doxorubicin, Macromol. Biosci. 2009, 9, 1254-1261.

40.     H.L. Sun, B.N. Guo, R. Cheng, F.H. Meng*, H.Y. Liu, Z.Y. Zhong*, Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin, Biomaterials 2009, 30, 6358-6366.

41.     H.F. Xu, F.H. Meng*, Z.Y. Zhong*, Reversibly crosslinked temperature-responsive nano-sized polymersomes: synthesis and triggered drug release, J. Mater. Chem. 2009, 19: 4183-4190.

42.     F.H. Meng, W.E.Hennink, Z.Y. Zhong*, Reduction-Sensitive Polymers and Bioconjugates for Biomedical Applications, Biomaterials 2009, 30, 2180-2198.

43.     F.H. Meng, Z.Y. Zhong*, J. Feijen, Stimuli-responsive polymersomes for programmed drug delivery. Biomacromolecules 2009, 10, 197-209.

44.     F.H. Meng, G.H.M. Engbers, J. Feijen, Biodegradable polymersomes as a basis for artificial cells: encapsulation, release and targeting. J. Controlled Release, 2005, 101, 187-198.

45.     F.H. Meng, G.H.M. Engbers, J.Feijen, Polyethylene glycol-grafted polystyrene particles. J. Biomed. Mater. Res., 2004, 70A, 49-58. 

46.     F.H. Meng, G.H.M. Engbers, A. Gessner, R.H. Müller, J. Feijen, Pegylated polystyrene particles as a model system for artificial cells. J. Biomed. Mater. Res., 2004, 70A, 97-106. 

47.     F.H. Meng, C. Hiemstra, G.H.M. Engbers, J. Feijen, Biodegradable polymersomes. Macromolecules 2003, 36, 3004-3006.

48.     F.H. Meng, G.H.M. Engbers, J.Feijen, Preparation and in vitro evaluation of polyethylene glycol modified microspheres. J. Controlled Release 2003, 87, 243-245.

49.     F.H. Meng, G.Q. Yu, B.T. Huang, Polymer-supported zirconocene catalyst for ethylene polymerization. J. Polym. Sci. Part A: Polym. Chem. 1999, 37, 37-46.

 

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