Huanli Sun
Release Time:2019-12-28

Dr. Huanli Sun is an associate professor at College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou,China. She obtained her B.S. and Ph.D degrees from Soochow University in 2008 and 2013, respectively, under the supervision of Prof. Zhiyuan Zhong. Afterwards, she worked as a postdoctoral research fellow with Prof. Frank Caruso at The University of Melbourne, Australia. She then joined the Biomedical Polymers Laboratory at Soochow University in Sep. 2015. She has published over 40 peer-reviewed papers with a total citation of >1,700. Her current research interests are developing multifunctional polymeric nanomedicines, and exploring monoclonal antibody and polysaccharide mediated active tumor chemotherapy.

Representative Papers

1. P. Yao; Y. Zhang; H. Meng; H. Sun*; Z. Zhong*, Smart Polymersomes Dually Functionalized with cRGD and Fusogenic Gala Peptides Enable Specific and High-Efficiency Cytosolic Delivery of Apoptotic Proteins Biomacromolecules 201920, 184-191.

2. Y. Zhang; K. Wu; H. Sun*; J. Zhang; J. Yuan; Z. Zhong*, Hyaluronic Acid-Shelled Disulfide-Cross-Linked Nanopolymersomes for Ultrahigh-Efficiency Reactive Encapsulation and CD44-Targeted Delivery of Mertansine Toxin ACS Applied Materials & Interfaces 201810, 1597-1604.

3. H. Sun; Y. Zhang; Z. Zhong, Reduction-Sensitive Polymeric Nanomedicines: An Emerging Multifunctional Platform for Targeted Cancer Therapy Advanced Drug Delivery Reviews 2018132, 16-32.

4. H. Sun; H.-A. Klok; Z. Zhong, Polymers from Nature and for Nature Biomacromolecules 201819, 1697-1700.

5. H. Sun; Y. Dong; F. Jan; Z. Zhong, Peptide-Decorated Polymeric Nanomedicines for Precision Cancer Therapy Journal of Controlled Release 2018290, 11-27.

6. H. Sun; J. Cui; Y. Ju; X. Chen; E.H.H. Wong; J. Tran; G.G. Qiao; F. Caruso, Tuning the Properties of Polymer Capsules for Cellular Interactions Bioconjugate Chemistry 201728, 1859-1865.

7. H.L. Sun; M. Bjornmalm; J.W. Cui; E.H.H. Wong; Y.L. Dai; Q. Dai; G.G. Qiao; F. Caruso, Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model ACS Macro Letters 20154, 1205-1209.

8. H. Sun; E.H.H. Wong; Y. Yan; J. Cui; Q. Dai; J. Guo; G.G. Qiao; F. Caruso, The Role of Capsule Stiffness on Cellular Processing Chemical Science 20156, 3505-3514.

9. H. Sun; R. Cheng; C. Deng; F. Meng; A.A. Dias; M. Hendriks; J. Feijen; Z. Zhong, Enzymatically and Reductively Degradable Alpha-Amino Acid-Based Poly(Ester Amide)S: Synthesis, Cell Compatibility, and Intracellular Anticancer Drug Delivery Biomacromolecules 201516, 597-605.

10. H. Sun; F. Meng; R. Cheng; C. Deng; Z. Zhong, Reduction-Responsive Polymeric Micelles and Vesicles for Triggered Intracellular Drug Release Antioxidants & Redox Signaling 201421, 755-767.

11. H. Sun; F. Meng; R. Cheng; C. Deng; Z. Zhong, Reduction and pH Dual-Bioresponsive Crosslinked Polymersomes for Efficient Intracellular Delivery of Proteins and Potent Induction of Cancer Cell Apoptosis Acta Biomaterialia 201410, 2159-2168.

12. H.L. Sun; F.H. Meng; R. Cheng; C. Deng; Z.Y. Zhong, Reduction-Sensitive Degradable Micellar Nanoparticles as Smart and Intuitive Delivery Systems for Cancer Chemotherapy Expert Opinion on Drug Delivery 201310, 1109-1122.

13. H.L. Sun; F.H. Meng; R. Cheng; C. Deng; Z.Y. Zhong, Reversibly Crosslinked pH-Sensitive Polymersomes for Efficient Intracellular Protein Delivery Journal of Controlled Release 2013172, E104-E104.

14. W. Wang; H.L. Sun (co-first author); F.H. Meng; S.B. Ma; H.Y. Liu; Z.Y. Zhong, Precise Control of Intracellular Drug Release and Anti-Tumor Activity of Biodegradable Micellar Drugs Via Reduction-Sensitive Shell-Shedding Soft Matter 20128, 3949-3956.

15. H.L. Sun; B.N. Guo; R. Cheng; F.H. Meng; H.Y. Liu; Z.Y. Zhong, Reduction-Responsive Shell-Sheddable Biodegradable Micelles for Intracellular Doxorubicin Delivery Journal of Controlled Release 2011152, E84-E85.

16. H. Sun; F. Meng; A.A. Dias; M. Hendriks; J. Feijen; Z. Zhong, Alpha-Amino Acid Containing Degradable Polymers as Functional Biomaterials: Rational Design, Synthetic Pathway, and Biomedical Applications Biomacromolecules 201112, 1937-1955.

17. H. Sun; B. Guo; X. Li; R. Cheng; F. Meng; H. Liu; Z. Zhong, Shell-Sheddable Micelles Based on Dextran-Ss-Poly(Epsilon-Caprolactone) Diblock Copolymer for Efficient Intracellular Release of Doxorubicin Biomacromolecules 201011, 848-854.

18. H. Sun; B. Guo; R. Cheng; F. Meng; H. Liu; Z. Zhong, Biodegradable Micelles with Sheddable Poly(Ethylene Glycol) Shells for Triggered Intracellular Release of Doxorubicin Biomaterials 200930, 6358-6366.

19. X. Gu; Y. Wei; Q. Fan; H. Sun; R. Cheng; Z. Zhong; C. Deng, cRGD-Decorated Biodegradable Polytyrosine Nanoparticles for Robust Encapsulation and Targeted Delivery of Doxorubicin to Colorectal Cancer in Vivo Journal of Controlled Release 2019301, 110-118.

20. S. Xue; X. Gu; J. Zhang; H. Sun; C. Deng; Z. Zhong, Construction of Small-Sized, Robust, and Reduction-Responsive Polypeptide Micelles for High Loading and Targeted Delivery of Chemotherapeutics Biomacromolecules 201819, 3586-3593.

21. M. Qiu; Z. Zhang; Y. Wei; H. Sun; F. Meng; C. Deng; Z. Zhong, Small-Sized and Robust Chimaeric Lipopepsomes: A Simple and Functional Platform with High Protein Loading for Targeted Intracellular Delivery of Protein Toxin in Vivo Chemistry of Materials 201830, 6831-6838.

22. X. Gu; M. Qiu; H. Sun; J. Zhang; L. Cheng; C. Deng; Z. Zhong, Polytyrosine Nanoparticles Enable Ultra-High Loading of Doxorubicin and Rapid Enzyme-Responsive Drug Release Biomaterials Science 20186, 1526-1534.

23. M. Qiu; X. Wang; H. Sun; J. Zhang; C. Deng; Z. Zhong, Cyclic RGD-Peptide-Functionalized Polylipopeptide Micelles for Enhanced Loading and Targeted Delivery of Monomethyl Auristatin E Molecular Pharmaceutics 201815, 4854-4861.

24. T. Chen; M. Qiu; J. Zhang; H. Sun; C. Deng; Z. Zhong, Integrated Multifunctional Micelles Co-Self-Assembled from Polypeptides Conjugated with Natural Ferulic Acid and Lipoic Acid for Doxorubicin Delivery ChemPhysChem 201819, 2070-2077.

25. M. Qiu; H. Sun; F. Meng; R. Cheng; J. Zhang; C. Deng; Z. Zhong, Lipopepsomes: A Novel and Robust Family of Nano-Vesicles Capable of Highly Efficient Encapsulation and Tumor-Targeted Delivery of Doxorubicin Hydrochloride in Vivo Journal of Controlled Release 2018272, 107-113.

26. P. Zhong; M. Qiu; J. Zhang; H. Sun; R. Cheng; C. Deng; F. Meng; Z. Zhong, cRGD-Installed Docetaxel-Loaded Mertansine Prodrug Micelles: Redox-Triggered Ratiometric Dual Drug Release and Targeted Synergistic Treatment of B16F10 Melanoma Nanotechnology 201728, 295103.

27. P. Zhong; H. Meng; J. Qiu; J. Zhang; H. Sun; R. Cheng; Z. Zhong, Alphavbeta3 Integrin-Targeted Reduction-Sensitive Micellar Mertansine Prodrug: Superb Drug Loading, Enhanced Stability, and Effective Inhibition of Melanoma Growth in Vivo Journal of Controlled Release 2017259, 176-186.

28. D. Song; J. Cui; H. Sun; T.-H. Nguyen; S. Alcantara; R. De Rose; S.J. Kent; C.J.H. Porter, et al., Templated Polymer Replica Nanoparticles to Facilitate Assessment of Material-Dependent Pharmacokinetics and Biodistribution ACS Applied Materials & Interfaces 20179, 33683-33694.

29. J. Wu; C. Deng; F. Meng; J. Zhang; H. Sun; Z. Zhong, Hyaluronic Acid Coated PLGA Nanoparticulate Docetaxel Effectively Targets and Suppresses Orthotopic Human Lung Cancer Journal of Controlled Release 2017259, 76-82.

30. M. Qiu; J. Ouyang; H. Sun; F. Meng; R. Cheng; J. Zhang; L. Cheng; Q. Lan, et al., Biodegradable Micelles Based on Poly(Ethylene Glycol)-B-Polylipopeptide Copolymer: A Robust and Versatile Nanoplatform for Anticancer Drug Delivery ACS Applied Materials & Interfaces 20179, 27587-27595.

31. J. Qiu; R. Cheng; J. Zhang; H. Sun; C. Deng; F. Meng; Z. Zhong, Glutathione-Sensitive Hyaluronic Acid-Mercaptopurine Prodrug Linked Via Carbonyl Vinyl Sulfide: A Robust and CD44-Targeted Nanomedicine for Leukemia Biomacromolecules 201718, 3207-3214.

32. Y. Fang; Y. Jiang; Y. Zou; F. Meng; J. Zhang; C. Deng; H. Sun; Z. Zhong, Targeted Glioma Chemotherapy by Cyclic RGD Peptide-Functionalized Reversibly Core-Crosslinked Multifunctional Poly(Ethylene Glycol)-B-Poly(Epsilon-Caprolactone) Micelles Acta Biomaterialia 201750, 396-406.

33. Y. Ju; J.W. Cui; H.L. Sun; M. Mullner; Y.L. Dai; J.L. Guo; N. Bertleff-Zieschang; T. Suma, et al., Engineered Metal-Phenolic Capsules Show Tunable Targeted Delivery to Cancer Cells Biomacromolecules 201617, 2268-2276.

34. X. Chen; J.W. Cui; H. Sun; M. Mullner; Y. Yan; K.F. Noi; Y. Ping; F. Caruso, Analysing Intracellular Deformation of Polymer Capsules Using Structured Illumination Microscopy Nanoscale 20168, 11924-11931.

35. Y. Ping; J.L. Guo; H. Ejima; X. Chen; J.J. Richardson; H.L. Sun; F. Caruso, pH-Responsive Capsules Engineered from Metal-Phenolic Networks for Anticancer Drug Delivery Small 201511, 2032-2036.

36. J. Lv; H. Sun; Y. Zou; F. Meng; A.A. Dias; M. Hendriks; J. Feijen; Z. Zhong, Reductively Degradable Alpha-Amino Acid-Based Poly(Ester Amide)-Graft-Galactose Copolymers: Facile Synthesis, Self-Assembly, and Hepatoma-Targeting Doxorubicin Delivery Biomaterials Science 20153, 1134-1146.

37. Q. Dai; Y. Yan; J.L. Guo; M. Bjornmalm; J.W. Cui; H.L. Sun; F. Caruso, Targeting Ability of Affibody-Functionalized Particles Is Enhanced by Albumin but Inhibited by Serum Coronas ACS Macro Letters 20154, 1259-1263.

38. J.L. Guo; H.L. Sun; K. Alt; B.L. Tardy; J.J. Richardson; T. Suma; H. Ejima; J.W. Cui, et al., Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and Cis-Diols Advanced Healthcare Materials 20154, 1796-1801.

39. Y.N. Zhong; W.J. Yang; H.L. Sun; R. Cheng; F.H. Meng; C. Deng; Z.Y. Zhong, Ligand-Directed Reduction-Sensitive Shell-Sheddable Biodegradable Micelles Actively Deliver Doxorubicin into the Nuclei of Target Cancer Cells Biomacromolecules 201314, 3723-3730.

40. X.Y. Wang; H.L. Sun; F.H. Meng; R. Cheng; C. Deng; Z.Y. Zhong, Galactose-Decorated Reduction-Sensitive Degradable Chimaeric Polymersomes as a Multifunctional Nanocarrier to Efficiently Chaperone Apoptotic Proteins into Hepatoma Cells Biomacromolecules 201314, 2873-2882.