孙欢利
时间:2019-12-26

孙欢利,博士,副教授,美国化学会期刊《生物大分子》副主编助理。2013年苏州大学获博士学位,20111-2月在荷兰帝斯曼公司培训学习。2013-2015年澳大利亚墨尔本大学博士后,2015年受聘为苏州大学副教授。在国际主流期刊发表论文40余篇,被引用1700多次。现负责主持一项国家自然科学青年基金项目和一项江苏省自然科学青年基金项目。主要研究方向为单克隆抗体及多糖介导的多功能性纳米药物用于癌症的靶向治疗。

代表性著作 

1. P. Yao; Y. Zhang; H. Meng; H. Sun*; Z. Zhong*, Smart Polymersomes Dually Functionalized with cRGD and Fusogenic Gala Peptides Enable Specific and High-Efficiency Cytosolic Delivery of Apoptotic Proteins Biomacromolecules2019, 20, 184-191.

2. Y. Zhang; K. Wu; H. Sun*; J. Zhang; J. Yuan; Z. Zhong*, Hyaluronic Acid-Shelled Disulfide-Cross-Linked Nanopolymersomes for Ultrahigh-Efficiency Reactive Encapsulation and CD44-Targeted Delivery of Mertansine Toxin ACS Applied Materials & Interfaces2018, 10, 1597-1604.

3. H. Sun; Y. Zhang; Z. Zhong, Reduction-Sensitive Polymeric Nanomedicines: An Emerging Multifunctional Platform for Targeted Cancer Therapy Advanced Drug Delivery Reviews2018, 132, 16-32.

4. H. Sun; H.-A. Klok; Z. Zhong, Polymers from Nature and for Nature Biomacromolecules2018, 19, 1697-1700.

5. H. Sun; Y. Dong; F. Jan; Z. Zhong, Peptide-Decorated Polymeric Nanomedicines for Precision Cancer TherapyJournal of Controlled Release2018, 290, 11-27.

6. H. Sun; J. Cui; Y. Ju; X. Chen; E.H.H. Wong; J. Tran; G.G. Qiao; F. Caruso, Tuning the Properties of Polymer Capsules for Cellular Interactions Bioconjugate Chemistry2017, 28, 1859-1865.

7. H.L. Sun; M. Bjornmalm; J.W. Cui; E.H.H. Wong; Y.L. Dai; Q. Dai; G.G. Qiao; F. Caruso, Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model ACS Macro Letters2015, 4, 1205-1209.

8. H. Sun; E.H.H. Wong; Y. Yan; J. Cui; Q. Dai; J. Guo; G.G. Qiao; F. Caruso, The Role of Capsule Stiffness on Cellular Processing Chemical Science2015, 6, 3505-3514.

9. H. Sun; R. Cheng; C. Deng; F. Meng; A.A. Dias; M. Hendriks; J. Feijen; Z. Zhong, Enzymatically and Reductively Degradable Alpha-Amino Acid-Based Poly(Ester Amide)S: Synthesis, Cell Compatibility, and Intracellular Anticancer Drug Delivery Biomacromolecules2015, 16, 597-605.

10. H. Sun; F. Meng; R. Cheng; C. Deng; Z. Zhong, Reduction-Responsive Polymeric Micelles and Vesicles for Triggered Intracellular Drug Release Antioxidants & Redox Signaling2014, 21, 755-767.

11. H. Sun; F. Meng; R. Cheng; C. Deng; Z. Zhong, Reduction and pH Dual-Bioresponsive Crosslinked Polymersomes for Efficient Intracellular Delivery of Proteins and Potent Induction of Cancer Cell Apoptosis Acta Biomaterialia2014, 10, 2159-2168.

12. H.L. Sun; F.H. Meng; R. Cheng; C. Deng; Z.Y. Zhong, Reduction-Sensitive Degradable Micellar Nanoparticles as Smart and Intuitive Delivery Systems for Cancer Chemotherapy Expert Opinion on Drug Delivery2013, 10, 1109-1122.

13. H.L. Sun; F.H. Meng; R. Cheng; C. Deng; Z.Y. Zhong, Reversibly Crosslinked pH-Sensitive Polymersomes for Efficient Intracellular Protein Delivery Journal of Controlled Release2013, 172, E104-E104.

14. W. Wang; H.L. Sun (co-first author); F.H. Meng; S.B. Ma; H.Y. Liu; Z.Y. Zhong, Precise Control of Intracellular Drug Release and Anti-Tumor Activity of Biodegradable Micellar Drugs Via Reduction-Sensitive Shell-Shedding Soft Matter2012, 8, 3949-3956.

15. H.L. Sun; B.N. Guo; R. Cheng; F.H. Meng; H.Y. Liu; Z.Y. Zhong, Reduction-Responsive Shell-Sheddable Biodegradable Micelles for Intracellular Doxorubicin Delivery Journal of Controlled Release2011, 152, E84-E85.

16. H. Sun; F. Meng; A.A. Dias; M. Hendriks; J. Feijen; Z. Zhong, Alpha-Amino Acid Containing Degradable Polymers as Functional Biomaterials: Rational Design, Synthetic Pathway, and Biomedical Applications Biomacromolecules2011, 12, 1937-1955.

17. H. Sun; B. Guo; X. Li; R. Cheng; F. Meng; H. Liu; Z. Zhong, Shell-Sheddable Micelles Based on Dextran-Ss-Poly(Epsilon-Caprolactone) Diblock Copolymer for Efficient Intracellular Release of Doxorubicin Biomacromolecules2010, 11, 848-854.

18. H. Sun; B. Guo; R. Cheng; F. Meng; H. Liu; Z. Zhong, Biodegradable Micelles with Sheddable Poly(Ethylene Glycol) Shells for Triggered Intracellular Release of Doxorubicin Biomaterials2009, 30, 6358-6366.

19. X. Gu; Y. Wei; Q. Fan; H. Sun; R. Cheng; Z. Zhong; C. Deng, cRGD-Decorated Biodegradable Polytyrosine Nanoparticles for Robust Encapsulation and Targeted Delivery of Doxorubicin to Colorectal Cancer in Vivo Journal of Controlled Release2019, 301, 110-118.

20. S. Xue; X. Gu; J. Zhang; H. Sun; C. Deng; Z. Zhong, Construction of Small-Sized, Robust, and Reduction-Responsive Polypeptide Micelles for High Loading and Targeted Delivery of Chemotherapeutics Biomacromolecules2018, 19, 3586-3593.

21. M. Qiu; Z. Zhang; Y. Wei; H. Sun; F. Meng; C. Deng; Z. Zhong, Small-Sized and Robust Chimaeric Lipopepsomes: A Simple and Functional Platform with High Protein Loading for Targeted Intracellular Delivery of Protein Toxin in Vivo Chemistry of Materials2018, 30, 6831-6838.

22. X. Gu; M. Qiu; H. Sun; J. Zhang; L. Cheng; C. Deng; Z. Zhong, Polytyrosine Nanoparticles Enable Ultra-High Loading of Doxorubicin and Rapid Enzyme-Responsive Drug Release Biomaterials Science2018, 6, 1526-1534.

23. M. Qiu; X. Wang; H. Sun; J. Zhang; C. Deng; Z. Zhong, Cyclic RGD-Peptide-Functionalized Polylipopeptide Micelles for Enhanced Loading and Targeted Delivery of Monomethyl Auristatin E Molecular Pharmaceutics2018, 15, 4854-4861.

24. T. Chen; M. Qiu; J. Zhang; H. Sun; C. Deng; Z. Zhong, Integrated Multifunctional Micelles Co-Self-Assembled from Polypeptides Conjugated with Natural Ferulic Acid and Lipoic Acid for Doxorubicin Delivery ChemPhysChem2018, 19, 2070-2077.

25. M. Qiu; H. Sun; F. Meng; R. Cheng; J. Zhang; C. Deng; Z. Zhong, Lipopepsomes: A Novel and Robust Family of Nano-Vesicles Capable of Highly Efficient Encapsulation and Tumor-Targeted Delivery of Doxorubicin Hydrochloride in Vivo Journal of Controlled Release2018, 272, 107-113.

26. P. Zhong; M. Qiu; J. Zhang; H. Sun; R. Cheng; C. Deng; F. Meng; Z. Zhong, cRGD-Installed Docetaxel-Loaded Mertansine Prodrug Micelles: Redox-Triggered Ratiometric Dual Drug Release and Targeted Synergistic Treatment of B16F10 Melanoma Nanotechnology2017, 28, 295103.

27. P. Zhong; H. Meng; J. Qiu; J. Zhang; H. Sun; R. Cheng; Z. Zhong, Alphavbeta3 Integrin-Targeted Reduction-Sensitive Micellar Mertansine Prodrug: Superb Drug Loading, Enhanced Stability, and Effective Inhibition of Melanoma Growth in Vivo Journal of Controlled Release2017, 259, 176-186.

28. D. Song; J. Cui; H. Sun; T.-H. Nguyen; S. Alcantara; R. De Rose; S.J. Kent; C.J.H. Porter, et al., Templated Polymer Replica Nanoparticles to Facilitate Assessment of Material-Dependent Pharmacokinetics and Biodistribution ACS Applied Materials & Interfaces2017, 9, 33683-33694.

29. J. Wu; C. Deng; F. Meng; J. Zhang; H. Sun; Z. Zhong, Hyaluronic Acid Coated PLGA Nanoparticulate Docetaxel Effectively Targets and Suppresses Orthotopic Human Lung Cancer Journal of Controlled Release2017, 259, 76-82.

30. M. Qiu; J. Ouyang; H. Sun; F. Meng; R. Cheng; J. Zhang; L. Cheng; Q. Lan, et al., Biodegradable Micelles Based on Poly(Ethylene Glycol)-B-Polylipopeptide Copolymer: A Robust and Versatile Nanoplatform for Anticancer Drug Delivery ACS Applied Materials & Interfaces2017, 9, 27587-27595.

31. J. Qiu; R. Cheng; J. Zhang; H. Sun; C. Deng; F. Meng; Z. Zhong, Glutathione-Sensitive Hyaluronic Acid-Mercaptopurine Prodrug Linked Via Carbonyl Vinyl Sulfide: A Robust and CD44-Targeted Nanomedicine for Leukemia Biomacromolecules2017, 18, 3207-3214.

32. Y. Fang; Y. Jiang; Y. Zou; F. Meng; J. Zhang; C. Deng; H. Sun; Z. Zhong, Targeted Glioma Chemotherapy by Cyclic RGD Peptide-Functionalized Reversibly Core-Crosslinked Multifunctional Poly(Ethylene Glycol)-B-Poly(Epsilon-Caprolactone) Micelles Acta Biomaterialia2017, 50, 396-406.

33. Y. Ju; J.W. Cui; H.L. Sun; M. Mullner; Y.L. Dai; J.L. Guo; N. Bertleff-Zieschang; T. Suma, et al., Engineered Metal-Phenolic Capsules Show Tunable Targeted Delivery to Cancer Cells Biomacromolecules2016, 17, 2268-2276.

34. X. Chen; J.W. Cui; H. Sun; M. Mullner; Y. Yan; K.F. Noi; Y. Ping; F. Caruso, Analysing Intracellular Deformation of Polymer Capsules Using Structured Illumination Microscopy Nanoscale2016, 8, 11924-11931.

35. Y. Ping; J.L. Guo; H. Ejima; X. Chen; J.J. Richardson; H.L. Sun; F. Caruso, pH-Responsive Capsules Engineered from Metal-Phenolic Networks for Anticancer Drug Delivery Small2015, 11, 2032-2036.

36. J. Lv; H. Sun; Y. Zou; F. Meng; A.A. Dias; M. Hendriks; J. Feijen; Z. Zhong, Reductively Degradable Alpha-Amino Acid-Based Poly(Ester Amide)-Graft-Galactose Copolymers: Facile Synthesis, Self-Assembly, and Hepatoma-Targeting Doxorubicin Delivery Biomaterials Science2015, 3, 1134-1146.

37. Q. Dai; Y. Yan; J.L. Guo; M. Bjornmalm; J.W. Cui; H.L. Sun; F. Caruso, Targeting Ability of Affibody-Functionalized Particles Is Enhanced by Albumin but Inhibited by Serum Coronas ACS Macro Letters2015, 4, 1259-1263.

38. J.L. Guo; H.L. Sun; K. Alt; B.L. Tardy; J.J. Richardson; T. Suma; H. Ejima; J.W. Cui, et al., Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and Cis-Diols Advanced Healthcare Materials2015, 4, 1796-1801.

39. Y.N. Zhong; W.J. Yang; H.L. Sun; R. Cheng; F.H. Meng; C. Deng; Z.Y. Zhong, Ligand-Directed Reduction-Sensitive Shell-Sheddable Biodegradable Micelles Actively Deliver Doxorubicin into the Nuclei of Target Cancer Cells Biomacromolecules2013, 14, 3723-3730.

40. X.Y. Wang; H.L. Sun; F.H. Meng; R. Cheng; C. Deng; Z.Y. Zhong, Galactose-Decorated Reduction-Sensitive Degradable Chimaeric Polymersomes as a Multifunctional Nanocarrier to Efficiently Chaperone Apoptotic Proteins into Hepatoma Cells Biomacromolecules2013, 14, 2873-2882.